ChemicalBook > CAS DataBase List > PRX-08066

PRX-08066

Product Name: PRX-08066
CAS No.: 866206-55-5
Chemical Name: PRX-08066
Synonyms: CS-2323;PRX-08066(96%);PRX-08066 (Maleate);PRX-08066 USP/EP/BP;PRX-08066 Maleic acid;PRX-08066 Maleic acid ，S8010;5-[[4-[(6-Chlorothieno[2,3-d]pyrimidin-4-yl)amino]-1-piperidinyl]methyl]-2-fluoro-benzonitrile (2Z)-2-butenedioate (1:1);Benzonitrile, 5-[[4-[(6-chlorothieno[2,3-d]pyrimidin-4-yl)amino]-1-piperidinyl]methyl]-2-fluoro-, (2Z)-2-butenedioate (1:1)
CBNumber: CB52681974
Molecular Formula: C23H21ClFN5O4S
Formula Weight: 517.9603432
MOL File: 866206-55-5.mol

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PRX-08066 Property

storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Powder

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: P839130
Product name: PRX-08066Maleicacid
Packaging: 100mg
Price: $1350
Updated: 2021/12/16

ApexBio Technology

Product number: A2098
Product name: PRX-08066Maleicacid
Packaging: 50mg
Price: $1485
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 48439
Product name: PRX-08066Maleicacid
Packaging: 10mg
Price: $850
Updated: 2021/12/16

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PRX-08066 Chemical Properties,Usage,Production

Uses

PRX-08066 Maleic acid is a selective 5-HT2BR antagonist. It has high selectivity over the closely related 5-HT2A and 5-HT2C receptors and other receptor targets.

Enzyme inhibitor

This selective 5-hydroxytryptamine (serotonin) receptor antagonist (FW = 517.96 g/mol; CAS = 866206-55-5), also named 5-((4-(6-chlorothieno[2,3- d]pyrimidin-4-ylamino)piperidin-1-yl)methyl)-2-fluorobenzonitrile, targets 5-HT2B (IC50 of 3.4 nM), showing high selectivity over the closely related 5-HT2A, 5-HT2C and other receptors and preventing the severity of pulmonary arterial hypertension in the monocrotaline (MCT)-induced rat pulmonary artery hypertension model. PRX-08066 significantly attenuates the elevation in pulmonary artery pressure and right ventricular hypertrophy, thereby improving cardiac function. Targeting the 5-5-HT2B receptor also appears be an effective antiproliferative and antifibrotic strategy for small intestinal neuroendocrine tumors (SI-NETs), because it inhibits tumor microenvironment fibroblasts as well as NET cells.

target

5-HT2B

IC 50

5-HT_2B Receptor: 3.4 nM (IC₅₀)

PRX-08066 Preparation Products And Raw materials

Raw materials

Preparation Products

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PRX-08066 Suppliers

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866206-55-5, PRX-08066Related Search:

VX-809 AZD-9291 Dynasore

5-[[4-[(6-Chlorothieno[2,3-d]pyrimidin-4-yl)amino]-1-piperidinyl]methyl]-2-fluoro-benzonitrile (2Z)-2-butenedioate (1:1)

PRX-08066 Maleic acid

Benzonitrile, 5-[[4-[(6-chlorothieno[2,3-d]pyrimidin-4-yl)amino]-1-piperidinyl]methyl]-2-fluoro-, (2Z)-2-butenedioate (1:1)

PRX-08066(96%)

CS-2323

PRX-08066 USP/EP/BP

PRX-08066 (Maleate)

PRX-08066 Maleic acid ，S8010

866206-55-5

C19H17ClFN5SC4H4O4

Inhibitors