PRX-08066
- Product Name
- PRX-08066
- CAS No.
- 866206-55-5
- Chemical Name
- PRX-08066
- Synonyms
- CS-2323;PRX-08066(96%);PRX-08066 (Maleate);PRX-08066 USP/EP/BP;PRX-08066 Maleic acid;5-[[4-[(6-Chlorothieno[2,3-d]pyrimidin-4-yl)amino]-1-piperidinyl]methyl]-2-fluoro-benzonitrile (2Z)-2-butenedioate (1:1);Benzonitrile, 5-[[4-[(6-chlorothieno[2,3-d]pyrimidin-4-yl)amino]-1-piperidinyl]methyl]-2-fluoro-, (2Z)-2-butenedioate (1:1)
- CBNumber
- CB52681974
- Molecular Formula
- C23H21ClFN5O4S
- Formula Weight
- 517.9603432
- MOL File
- 866206-55-5.mol
PRX-08066 Property
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Powder
N-Bromosuccinimide Price
- Product number
- P839130
- Product name
- PRX-08066Maleicacid
- Packaging
- 100mg
- Price
- $1350
- Updated
- 2021/12/16
- Product number
- A2098
- Product name
- PRX-08066Maleicacid
- Packaging
- 50mg
- Price
- $1485
- Updated
- 2021/12/16
- Product number
- 48439
- Product name
- PRX-08066Maleicacid
- Packaging
- 10mg
- Price
- $850
- Updated
- 2021/12/16
PRX-08066 Chemical Properties,Usage,Production
Uses
PRX-08066 Maleic acid is a selective 5-HT2BR antagonist. It has high selectivity over the closely related 5-HT2A and 5-HT2C receptors and other receptor targets.
Enzyme inhibitor
This selective 5-hydroxytryptamine (serotonin) receptor antagonist (FW = 517.96 g/mol; CAS = 866206-55-5), also named 5-((4-(6-chlorothieno[2,3- d]pyrimidin-4-ylamino)piperidin-1-yl)methyl)-2-fluorobenzonitrile, targets 5-HT2B (IC50 of 3.4 nM), showing high selectivity over the closely related 5-HT2A, 5-HT2C and other receptors and preventing the severity of pulmonary arterial hypertension in the monocrotaline (MCT)-induced rat pulmonary artery hypertension model. PRX-08066 significantly attenuates the elevation in pulmonary artery pressure and right ventricular hypertrophy, thereby improving cardiac function. Targeting the 5-5-HT2B receptor also appears be an effective antiproliferative and antifibrotic strategy for small intestinal neuroendocrine tumors (SI-NETs), because it inhibits tumor microenvironment fibroblasts as well as NET cells.
target
5-HT2B
PRX-08066 Preparation Products And Raw materials
Raw materials
Preparation Products
PRX-08066 Suppliers
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