tert-butyl ((1r,4r)-4-Morpholinocyclohexyl)carbaMate

Product Name: tert-butyl ((1r,4r)-4-Morpholinocyclohexyl)carbaMate
CAS No.: 558442-96-9
Chemical Name: tert-butyl ((1r,4r)-4-Morpholinocyclohexyl)carbaMate
Synonyms: 105471;tert-butyl N-(4-morpholinocyclohexyl)carbamate;tert-Butyl (trans-4-morpholinocyclohexyl)carbamate;tert-butyl ((1r,4r)-4-Morpholinocyclohexyl)carbaMate;Carbamic acid, N-[trans-4-(4-morpholinyl)cyclohexyl]-, 1,1-dimethylethyl ester
CBNumber: CB52684445
Molecular Formula: C15H28N2O3
Formula Weight: 284.39
MOL File: 558442-96-9.mol

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tert-butyl ((1r,4r)-4-Morpholinocyclohexyl)carbaMate Property

Boiling point:: 396.3±37.0 °C(Predicted)
Density: 1.07±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 12.50±0.40(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Matrix Scientific

Product number: 120887
Product name: tert-Butyl((1r,4r)-4-morpholinocyclohexyl)-carbamate
Purity: 97%
Packaging: 5g
Price: $1486
Updated: 2021/12/16

Matrix Scientific

Product number: 120887
Product name: tert-Butyl((1r,4r)-4-morpholinocyclohexyl)-carbamate
Purity: 97%
Packaging: 10g
Price: $2376
Updated: 2021/12/16

Crysdot

Product number: CD11104477
Product name: tert-Butyl(trans-4-morpholinocyclohexyl)carbamate
Purity: 95+%
Packaging: 10g
Price: $1882
Updated: 2021/12/16

Alichem

Product number: 558442969
Product name: tert-Butyl(trans-4-morpholinocyclohexyl)carbamate
Packaging: 10g
Price: $1996.05
Updated: 2021/12/16

Ambeed

Product number: A123528
Product name: tert-Butyl(trans-4-morpholinocyclohexyl)carbamate
Purity: 95+%
Packaging: 100mg
Price: $89
Updated: 2021/12/16

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tert-butyl ((1r,4r)-4-Morpholinocyclohexyl)carbaMate Chemical Properties,Usage,Production

Synthesis

5414-19-7

177906-48-8

558442-96-9

The general procedure for the synthesis of tert-butyl (trans-4-morpholinocyclohexyl)carbamate from 2,2'-dibromodiethyl ether and tert-butyl trans-(4-aminocyclohexyl)carbamate was as follows: 21.43 g (0.1 mol) of tert-butyl N-(trans-4-aminocyclohexyl)carbamate was dissolved into 250 mL of N,N-dimethylformamide, followed by addition of 16.76 mL (0.12 mol) bis(2-bromoethyl) ether and 34.85 mL (0.25 mol) triethylamine. The reaction mixture was stirred at 70°C for 6 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was dissolved in ethyl acetate, and the organic layer was washed sequentially with aqueous sodium carbonate and saturated brine solution, and then dried over anhydrous sodium sulfate. The solvent was again removed by reduced pressure distillation and the residue was purified by silica gel column chromatography (elution gradient: from pure chloroform to chloroform/methanol=30/1) to give 19.92 g (70% yield) of tert-butyl (trans-4-morpholino cyclohexyl)carbamate.

References

[1] Patent: EP1775298, 2007, A1. Location in patent: Page/Page column 33-34

tert-butyl ((1r,4r)-4-Morpholinocyclohexyl)carbaMate Preparation Products And Raw materials

Raw materials

Preparation Products

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tert-butyl ((1r,4r)-4-Morpholinocyclohexyl)carbaMate Suppliers

China 25 India 2 United States 2 Global 29

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558442-96-9, tert-butyl ((1r,4r)-4-Morpholinocyclohexyl)carbaMateRelated Search:

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tert-butyl ((1r,4r)-4-Morpholinocyclohexyl)carbaMate

tert-Butyl (trans-4-morpholinocyclohexyl)carbamate

105471

Carbamic acid, N-[trans-4-(4-morpholinyl)cyclohexyl]-, 1,1-dimethylethyl ester

tert-butyl N-(4-morpholinocyclohexyl)carbamate

558442-96-9