BOC-GLU(OBZL)-OME
- Product Name
- BOC-GLU(OBZL)-OME
- CAS No.
- 59279-58-2
- Chemical Name
- BOC-GLU(OBZL)-OME
- Synonyms
- BOC-GLU(OBZL)-OME;Boc-L-Glu(OBzl)-OMe;(Tert-Butoxy)Carbonyl Glu(OBzl)-OMe;Boc-L-glutamicacid-benzyla-methylester;Boc-L-Glutamic Acid 5-Benzyl 1-Methyl Ester;Boc-L-glutamic acid γ-benzyl α-methyl ester;BOC-L-GLUTAMIC ACID-Y-BENZYL A-METHYL-DIESTER;5-Benzyl 1-Methyl (S)-2-(Boc-amino)pentanedioate;BOC-L-GLUTAMIC ACID-GAMMA-BENZYL ALPHA-METHYL-DIESTER;BOC-L-GLUTAMIC ACID .GAMMA.-BENZYL .ALPHA.-METHYL ESTER
- CBNumber
- CB5269761
- Molecular Formula
- C18H25NO6
- Formula Weight
- 351.39
- MOL File
- 59279-58-2.mol
BOC-GLU(OBZL)-OME Property
- Melting point:
- 38-41 °C
- Boiling point:
- 471.2±40.0 °C(Predicted)
- Density
- 1.144±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- pka
- 10.96±0.46(Predicted)
- Appearance
- White to light yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- AS112951
- Product name
- Boc-Glu(Obzl)-OMe
- Purity
- 95%
- Packaging
- 5G
- Price
- $149
- Updated
- 2021/12/16
- Product number
- 8817AB
- Product name
- Boc-Glu(OBzl)-OMe
- Packaging
- 5g
- Price
- $182
- Updated
- 2021/12/16
- Product number
- AAA0009071
- Product name
- (S)-5-BENZYL 1-METHYL-2-(TERT-BUTOXYCARBONYLAMINO)PENTANEDIOATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.26
- Updated
- 2021/12/16
- Product number
- AS112951
- Product name
- Boc-Glu(Obzl)-OMe
- Purity
- 95%
- Packaging
- 25g
- Price
- $583
- Updated
- 2021/12/16
- Product number
- AAA0009071
- Product name
- (S)-5-BENZYL 1-METHYL-2-(TERT-BUTOXYCARBONYLAMINO)PENTANEDIOATE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $735
- Updated
- 2021/12/16
BOC-GLU(OBZL)-OME Chemical Properties,Usage,Production
Synthesis
13574-13-5
74-88-4
59279-58-2
Step 1: Iodomethane (1.01 mL, 16.3 mmol) was slowly added dropwise to a mixed solution of THF (14.82 mmol) and DMF (25 mL) of (2S)-5-(benzyloxy)-2-{[(tert-butoxy)carbonyl]amino}-5-oxopentanoic acid (5.00 g) along with K2CO3 (2.25 g, 16.3 mmol). The reaction mixture was stirred at room temperature for about 3 hours before iodomethane (1.01 mL, 16.3 mmol) was added again. Subsequently, EtOAc was added to the reaction mixture and washed three times with 10% Na2S2O3 solution and then dried with MgSO4. After concentration under reduced pressure to remove the solvent, the crude product was purified by silica gel column chromatography (100:1, followed by 50:1 CHCl3/MeOH) to afford methyl (S)-5-benzyl-2-((tert-butoxycarbonyl)amino)pentanedioate (4.20 g, 12.23 mmol, 82% yield). m/z of C18H25NO6 was detected by ESIMS as 352 (M + H ).
References
[1] Journal of Medicinal Chemistry, 2016, vol. 59, # 5, p. 1899 - 1913
[2] Patent: US2008/318957, 2008, A1. Location in patent: Page/Page column 41-42
[3] Patent: WO2012/109164, 2012, A1. Location in patent: Page/Page column 39
[4] Organic and Biomolecular Chemistry, 2007, vol. 5, # 12, p. 1915 - 1923
[5] Organic Letters, 2016, vol. 18, # 9, p. 1968 - 1971
BOC-GLU(OBZL)-OME Preparation Products And Raw materials
Raw materials
Preparation Products
BOC-GLU(OBZL)-OME Suppliers
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- +1-631-485-4226
- Fax
- 1-631-614-7828
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- United States
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View Lastest Price from BOC-GLU(OBZL)-OME manufacturers
- Product
- BOC-GLU(OBZL)-OME 59279-58-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-18