GSA 10

Product Name: GSA 10
CAS No.: 300833-95-8
Chemical Name: GSA 10
Synonyms: GSA 10;propyl 4-[(1-hexyl-4-hydroxy-2-oxo-quinoline-3-carbonyl)amino]benzoate;Propyl 4-(1-hexyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)benzoate;4-[[(1-Hexyl-1,2-dihydro-2-oxo-3-quinolinyl)carbonyl]amino]benzoic acid propyl ester;Benzoic acid, 4-[[(1-hexyl-1,2-dihydro-4-hydroxy-2-oxo-3-quinolinyl)carbonyl]amino]-, propyl ester;Inhibitor,differentiation,regenerative medicine,Smoothened receptor,quinolinecarboxamide derivative,cancer,Smoothened,GSA 10,GSA-10,Smo,osteoblasts,Hedgehog,GSA10,inhibit,multipotent mesenchymal progenitor cell
CBNumber: CB52716245
Molecular Formula: C26H30N2O5
Formula Weight: 450.53
MOL File: 300833-95-8.mol

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GSA 10 Property

Boiling point:: 620.2±55.0 °C(Predicted)
Density: 1.240±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble to 5 mM in DMSO with gentle warming
form: Powder
pka: 4.50±1.00(Predicted)
color: White to light yellow
InChI: 1S/C26H30N2O5/c1-3-5-6-9-16-28-21-11-8-7-10-20(21)23(29)22(25(28)31)24(30)27-19-14-12-18(13-15-19)26(32)33-17-4-2/h7-8,10-15,29H,3-6,9,16-17H2,1-2H3,(H,27,30)
InChIKey: MDLUYYGRCGDKGL-UHFFFAOYSA-N
SMILES: OC(C1=CC=CC=C1N2CCCCCC)=C(C(NC3=CC=C(C(OCCC)=O)C=C3)=O)C2=O

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Safety

WGK Germany: WGK 3
Storage Class: 11 - Combustible Solids
Hazard Classifications: Acute Tox. 4 Oral

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1171
Product name: GSA-10
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $129
Updated: 2026/03/19

Cayman Chemical

Product number: 16164
Product name: GSA 10
Purity: ≥95%
Packaging: 5mg
Price: $85
Updated: 2024/03/01

Cayman Chemical

Product number: 16164
Product name: GSA 10
Purity: ≥95%
Packaging: 10mg
Price: $158
Updated: 2024/03/01

Cayman Chemical

Product number: 16164
Product name: GSA 10
Purity: ≥95%
Packaging: 25mg
Price: $374
Updated: 2024/03/01

Cayman Chemical

Product number: 16164
Product name: GSA 10
Purity: ≥95%
Packaging: 50mg
Price: $702
Updated: 2024/03/01

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GSA 10 Chemical Properties,Usage,Production

Description

Smoothened (SMO) is a cell surface receptor that, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors. GSA 10 is a quinolinecarboxamide derivative that acts as an agonist of SMO. By acting at SMO, GSA 10 has been shown to promote the differentiation of multipotent mesenchymal progenitor cells into osteoblasts (EC₅₀ = 1.2 μM). Most notably, GSA 10 does not recognize the classic cyclopamine binding site as do other SMO agonists and as such has been used to characterize a novel SMO active site.

Uses

GSA 10 is a novel small-molecule positive modulator of smoothened. GSA 10 may have therapeutic interests in regenerative medicine.

References

[1] TATIANA GOROJANKINA. Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened.[J]. Molecular Pharmacology, 2013, 83 5: 1020-1029. DOI: 10.1124/mol.112.084590

GSA 10 Preparation Products And Raw materials

Raw materials

Preparation Products

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GSA 10 Suppliers

China 48 India 1 United Kingdom 3 United States 6 Global 58

Shanghai Lollane Biological Technology Co.,Ltd.

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Novachemistry

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300833-95-8, GSA 10Related Search:

Propyl 4-(1-hexyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)benzoate

propyl 4-[(1-hexyl-4-hydroxy-2-oxo-quinoline-3-carbonyl)amino]benzoate

GSA 10

4-[[(1-Hexyl-1,2-dihydro-2-oxo-3-quinolinyl)carbonyl]amino]benzoic acid propyl ester

Inhibitor,differentiation,regenerative medicine,Smoothened receptor,quinolinecarboxamide derivative,cancer,Smoothened,GSA 10,GSA-10,Smo,osteoblasts,Hedgehog,GSA10,inhibit,multipotent mesenchymal progenitor cell

Benzoic acid, 4-[[(1-hexyl-1,2-dihydro-4-hydroxy-2-oxo-3-quinolinyl)carbonyl]amino]-, propyl ester

300833-95-8