MF 438

Product Name: MF 438
CAS No.: 921605-87-0
Chemical Name: MF 438
Synonyms: MF 438;MF-438, 10 mM in DMSO;Stearoyl-CoA Desaturase (SCD),inhibit,MF438,MF 438,MF-438,Inhibitor;3-(5-Methyl-1,3,4-thiadiazol-2-yl)-6-[4-[2-(trifluoromethyl)phenoxy]-1-piperidinyl]pyridazine;2-methyl-5-[6-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]pyridazin-3-yl]-1,3,4-thiadiazole;Pyridazine, 3-(5-methyl-1,3,4-thiadiazol-2-yl)-6-[4-[2-(trifluoromethyl)phenoxy]-1-piperidinyl]-;3-(5-Methyl-1,3,4-thiadiazol-2-yl)-6-[4-[2-(trifluoromethyl)phenoxy]-1-piperidinyl]pyridazine(MF-438)
CBNumber: CB52716285
Molecular Formula: C19H18F3N5OS
Formula Weight: 421.44
MOL File: 921605-87-0.mol

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MF 438 Property

Boiling point:: 614.5±65.0 °C(Predicted)
Density: 1.365±0.06 g/cm3(Predicted)
storage temp.: -20°
solubility: Soluble in DMSO (up to 5 mg/ml) or in Ethanol (up to 2 mg/ml with warming).
form: solid
pka: 2.29±0.10(Predicted)
color: Off-white
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0009306
Product name: MF-438
Purity: 99.92%
Packaging: 5mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-0009306
Product name: MF-438
Purity: 99.92%
Packaging: 10mg
Price: $380
Updated: 2021/12/16

ChemScene

Product number: CS-0009306
Product name: MF-438
Purity: 99.92%
Packaging: 50mg
Price: $1150
Updated: 2021/12/16

ChemScene

Product number: CS-0009306
Product name: MF-438
Purity: 99.92%
Packaging: 100mg
Price: $1650
Updated: 2021/12/16

DC Chemicals

Product number: 020466
Product name: MF-438
Packaging: 003
Price: $1800
Updated: 2021/12/16

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MF 438 Chemical Properties,Usage,Production

Description

MF-438 (921605-87-0) is a potent inhibitor of stearoyl-CoA desaturase 1 (SCD1) – IC50= 2.3 nM.1MF-438 was potent in anin vivomouse liver PD assay (ED50between 1 and 3 mg/kg).1Cancer initiating cells (CSC-like) were shown to be much more sensitive to MF-438 inhibition of SCD1 than progenitor and terminally differentiated cancer cells in a lung cancer model.2MF-438 showed good oral bioavailability and metabolic stability making it an excellent tool for studying the effects of SCD1 in various disease models.

Uses

MF-438 is a potent and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor with an IC50 of 2.3 nM for rSCD1[1].

in vivo

MF-438 exhibits an ED₅₀ between 1 and 3 mg/kg in a mouse model^[1].

References

[1] SERGE LÉGER. Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438)[J]. Bioorganic & Medicinal Chemistry Letters, 2010, 20 2: Pages 499-502. DOI:10.1016/j.bmcl.2009.11.111
[2] A NOTO. Stearoyl-CoA desaturase-1 is a key factor for lung cancer-initiating cells[J]. Cell Death & Disease, 2013, 4 12: e947-e947. DOI:10.1038/cddis.2013.444
[3] N. RODRIGUEZ-PEREZ. Altered fatty acid metabolism and reduced stearoyl-coenzyme a desaturase activity in asthma[J]. Allergy, 2017, 72 11: 1744-1752. DOI:10.1111/all.13180

MF 438 Preparation Products And Raw materials

Raw materials

Preparation Products

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MF 438 Suppliers

China 44 United States 5 Global 49

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070 13913916777
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 16059
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Beijing Yisiyan Technology Research Center

Tel: 010-56645598 13366904824
Fax: 01062230033
Email: bjkaida@163.com
Country: China
ProdList: 1603
Advantage: 59

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4827
Advantage: 55

SPIRO PHARMA

Tel
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Email: eric_feng1954@126.com
Country: China
ProdList: 9248
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Zhengzhou Alfachem Co.,Ltd.

Tel: 0371-53778726 18003825608
Fax: 2885354392
Email: liuxiaoyan@alfachem.cn
Country: China
ProdList: 1988
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Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 89689
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ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 7999
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Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
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Dezhou LonWel Pharmaceutical Technology Co., Ltd.

Tel: 13761310616
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Country: China
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Angel Pharmatech, Ltd.

Tel: 17317130613
Fax: QQ3358272972
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921605-87-0, MF 438Related Search:

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MF 438

2-methyl-5-[6-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]pyridazin-3-yl]-1,3,4-thiadiazole

3-(5-Methyl-1,3,4-thiadiazol-2-yl)-6-[4-[2-(trifluoromethyl)phenoxy]-1-piperidinyl]pyridazine

Pyridazine, 3-(5-methyl-1,3,4-thiadiazol-2-yl)-6-[4-[2-(trifluoromethyl)phenoxy]-1-piperidinyl]-

3-(5-Methyl-1,3,4-thiadiazol-2-yl)-6-[4-[2-(trifluoromethyl)phenoxy]-1-piperidinyl]pyridazine(MF-438)

Stearoyl-CoA Desaturase (SCD),inhibit,MF438,MF 438,MF-438,Inhibitor

MF-438, 10 mM in DMSO

921605-87-0