MF 438

Product Name: MF 438
CAS No.: 921605-87-0
Chemical Name: MF 438
Synonyms: MF 438;Stearoyl-CoA Desaturase (SCD),inhibit,MF438,MF 438,MF-438,Inhibitor;3-(5-Methyl-1,3,4-thiadiazol-2-yl)-6-[4-[2-(trifluoromethyl)phenoxy]-1-piperidinyl]pyridazine;2-methyl-5-[6-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]pyridazin-3-yl]-1,3,4-thiadiazole;Pyridazine, 3-(5-methyl-1,3,4-thiadiazol-2-yl)-6-[4-[2-(trifluoromethyl)phenoxy]-1-piperidinyl]-;3-(5-Methyl-1,3,4-thiadiazol-2-yl)-6-[4-[2-(trifluoromethyl)phenoxy]-1-piperidinyl]pyridazine(MF-438)
CBNumber: CB52716285
Molecular Formula: C19H18F3N5OS
Formula Weight: 421.44
MOL File: 921605-87-0.mol

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MF 438 Property

Boiling point:: 614.5±65.0 °C(Predicted)
Density: 1.365±0.06 g/cm3(Predicted)
storage temp.: -20°
solubility: Soluble in DMSO (up to 5 mg/ml) or in Ethanol (up to 2 mg/ml with warming).
form: solid
pka: 2.29±0.10(Predicted)
color: Off-white
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0009306
Product name: MF-438
Purity: 99.92%
Packaging: 5mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-0009306
Product name: MF-438
Purity: 99.92%
Packaging: 10mg
Price: $380
Updated: 2021/12/16

ChemScene

Product number: CS-0009306
Product name: MF-438
Purity: 99.92%
Packaging: 50mg
Price: $1150
Updated: 2021/12/16

ChemScene

Product number: CS-0009306
Product name: MF-438
Purity: 99.92%
Packaging: 100mg
Price: $1650
Updated: 2021/12/16

DC Chemicals

Product number: 020466
Product name: MF-438
Packaging: 003
Price: $1800
Updated: 2021/12/16

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MF 438 Chemical Properties,Usage,Production

Description

MF-438 (921605-87-0) is a potent inhibitor of stearoyl-CoA desaturase 1 (SCD1) – IC50?= 2.3 nM.1?MF-438 was potent in an?in vivo?mouse liver PD assay (ED50?between 1 and 3 mg/kg).1?Cancer initiating cells (CSC-like) were shown to be much more sensitive to MF-438 inhibition of SCD1 than progenitor and terminally differentiated cancer cells in a lung cancer model.2?MF-438 showed good oral bioavailability and metabolic stability making it an excellent tool for studying the effects of SCD1 in various disease models.

References

1) Leger?et al. (2010),?Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438); Bioorg. Med. Chem. Lett.,?20?499 2) Noto?et al. (2013),?Stearoyl-CoA desaturase-1 is a key factor for lung cancer-initiating cells; Cell Death and Differ.,?4?e947 3) Rodriguez-Perez?et al.?(2017),?Altered fatty acid metabolism and reduced stearoyl-coenzyme A desaturase activity in asthma; Allergy,?72?1744 [Citation]

MF 438 Preparation Products And Raw materials

Raw materials

Preparation Products

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MF 438 Suppliers

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921605-87-0, MF 438Related Search:

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MF 438

2-methyl-5-[6-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]pyridazin-3-yl]-1,3,4-thiadiazole

3-(5-Methyl-1,3,4-thiadiazol-2-yl)-6-[4-[2-(trifluoromethyl)phenoxy]-1-piperidinyl]pyridazine

Pyridazine, 3-(5-methyl-1,3,4-thiadiazol-2-yl)-6-[4-[2-(trifluoromethyl)phenoxy]-1-piperidinyl]-

3-(5-Methyl-1,3,4-thiadiazol-2-yl)-6-[4-[2-(trifluoromethyl)phenoxy]-1-piperidinyl]pyridazine(MF-438)

Stearoyl-CoA Desaturase (SCD),inhibit,MF438,MF 438,MF-438,Inhibitor

921605-87-0