ChemicalBook > CAS DataBase List > MF 438

MF 438

Product Name: MF 438
CAS No.: 921605-87-0
Chemical Name: MF 438
Synonyms: MF 438;MF-438, 10 mM in DMSO;Stearoyl-CoA Desaturase (SCD),inhibit,MF438,MF 438,MF-438,Inhibitor;3-(5-Methyl-1,3,4-thiadiazol-2-yl)-6-[4-[2-(trifluoromethyl)phenoxy]-1-piperidinyl]pyridazine;2-methyl-5-[6-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]pyridazin-3-yl]-1,3,4-thiadiazole;Pyridazine, 3-(5-methyl-1,3,4-thiadiazol-2-yl)-6-[4-[2-(trifluoromethyl)phenoxy]-1-piperidinyl]-;3-(5-Methyl-1,3,4-thiadiazol-2-yl)-6-[4-[2-(trifluoromethyl)phenoxy]-1-piperidinyl]pyridazine(MF-438)
CBNumber: CB52716285
Molecular Formula: C19H18F3N5OS
Formula Weight: 421.44
MOL File: 921605-87-0.mol

Less

MF 438 Property

Boiling point:: 614.5±65.0 °C(Predicted)
Density: 1.365±0.06 g/cm3(Predicted)
storage temp.: -20°
solubility: Soluble in DMSO (up to 5 mg/ml) or in Ethanol (up to 2 mg/ml with warming).
form: solid
pka: 2.29±0.10(Predicted)
color: Off-white
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.

Less

Hazard and Precautionary Statements (GHS)

Less

N-Bromosuccinimide Price

ChemScene

Product number: CS-0009306
Product name: MF-438
Purity: 99.92%
Packaging: 5mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-0009306
Product name: MF-438
Purity: 99.92%
Packaging: 10mg
Price: $380
Updated: 2021/12/16

ChemScene

Product number: CS-0009306
Product name: MF-438
Purity: 99.92%
Packaging: 50mg
Price: $1150
Updated: 2021/12/16

ChemScene

Product number: CS-0009306
Product name: MF-438
Purity: 99.92%
Packaging: 100mg
Price: $1650
Updated: 2021/12/16

Ambeed

Product number: A1148548
Product name: 2-Methyl-5-(6-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-yl)pyridazin-3-yl)-1,3,4-thiadiazole
Purity: 95+%
Packaging: 1mg
Price: $130
Updated: 2021/12/16

Less

MF 438 Chemical Properties,Usage,Production

Description

MF-438 (921605-87-0) is a potent inhibitor of stearoyl-CoA desaturase 1 (SCD1) – IC50?= 2.3 nM.1?MF-438 was potent in an?in vivo?mouse liver PD assay (ED50?between 1 and 3 mg/kg).1?Cancer initiating cells (CSC-like) were shown to be much more sensitive to MF-438 inhibition of SCD1 than progenitor and terminally differentiated cancer cells in a lung cancer model.2?MF-438 showed good oral bioavailability and metabolic stability making it an excellent tool for studying the effects of SCD1 in various disease models.

Uses

MF-438 is a potent and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor with an IC50 of 2.3 nM for rSCD1[1].

in vivo

MF-438 exhibits an ED₅₀ between 1 and 3 mg/kg in a mouse model^[1].

References

[1] SERGE LÉGER. Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438)[J]. Bioorganic & Medicinal Chemistry Letters, 2010, 20 2: Pages 499-502. DOI:10.1016/j.bmcl.2009.11.111
[2] A NOTO. Stearoyl-CoA desaturase-1 is a key factor for lung cancer-initiating cells[J]. Cell Death & Disease, 2013, 4 12: e947-e947. DOI:10.1038/cddis.2013.444
[3] N. RODRIGUEZ-PEREZ. Altered fatty acid metabolism and reduced stearoyl-coenzyme a desaturase activity in asthma[J]. Allergy, 2017, 72 11: 1744-1752. DOI:10.1111/all.13180

MF 438 Preparation Products And Raw materials

Raw materials

Preparation Products

Less

MF 438 Suppliers

China 44 United States 5 Global 49

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 16075
Advantage: 64

Beijing Yisiyan Technology Research Center

Tel: 010-56645598 13366904824
Fax: 01062230033
Email: bjkaida@163.com
Country: China
ProdList: 1618
Advantage: 59

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4769
Advantage: 55

SPIRO PHARMA

Tel
Fax: -
Email: eric_feng1954@126.com
Country: China
ProdList: 9248
Advantage: 55

Zhengzhou Alfachem Co.,Ltd.

Tel: 0371-53778726 18003825608
Fax: QQ：2885354392
Email: liuxiaoyan@alfachem.cn
Country: China
ProdList: 1986
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9125
Advantage: 58

Dezhou LonWel Pharmaceutical Technology Co., Ltd.

Tel: 13761310616
Fax: QQ: 39324283
Email: 39324283@qq.com
Country: China
ProdList: 1632
Advantage: 58

Angel Pharmatech, Ltd.

Tel: 17317130613
Fax: QQ3358272972
Email: 3358272972@qq.com
Country: China
ProdList: 3277
Advantage: 58

Baimei Jihua (Henan) Pharmaceutical Technology Co., Ltd

Tel: 037188900765 18037465274
Fax: QQ3430974218
Email: enyawanglei@sina.cn
Country: China
ProdList: 13966
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

Jingmo (Xiamen) Biotechnology Co., Ltd

Tel: 13621943973; 13621943973
Email: sales@jamxmpharmatech.com
Country: China
ProdList: 1168
Advantage: 58

Jinan Jiuli Biotechnology Co. , Ltd.

Tel: 15865264761
Email: 486064515@qq.com
Country: China
ProdList: 4810
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29757
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 59936
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Aikon International Limited

Tel: 025-58859352 18921922613
Email: hywu@aikonchem.com
Country: China
ProdList: 10709
Advantage: 58

Shanghai Jieshikai Biotechnology Co. , Ltd.

Tel: 021-57520305 13795461237
Email: zhuruyan@jskchem.com
Country: China
ProdList: 49234
Advantage: 58

https://hanhongsci.com/

Tel: 021-54306202 18917919676
Email: info@hanhongsci.com
Country: China
ProdList: 29995
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: cindy.huang@synzest.com
Country: China
ProdList: 12000
Advantage: 58

RD International Technology Co., Limited

Tel: 18024082417
Email: market@ubiochem.com
Country: China
ProdList: 9835
Advantage: 58

Sangon Biotech (Shanghai) Co.,Ltd.

Tel: 400-821-026
Email: Sales@sangon.com
Country: China
ProdList: 6710
Advantage: 58

Cayman Chemical Company

Tel: 800-364-9897
Email: sales@caymanchem.com
Country: China
ProdList: 6838
Advantage: 58

Biosynth Biological Technology (Suzhou) Co Ltd

Tel: 51288865780
Email: sales@biosynth.com
Country: China
ProdList: 6051
Advantage: 58

Adooq Bioscience LLC

Tel: 400-025-6535
Email: sales@adooq.cn
Country: China
ProdList: 6215
Advantage: 58

Selleck Chemicals

Tel: 400-668-6834
Email: info@selleck.cn
Country: China
ProdList: 6071
Advantage: 58

ATK CHEMICAL COMPANY LIMITED

Tel: +undefined-21-51877795
Fax: +86 21 5161 9052/ 5187 7796
Email: ivan@atkchemical.com
Country: China
ProdList: 33024
Advantage: 60

Zibo Hangyu Biotechnology Development Co., Ltd

Tel: +86-0533-2185556 +8615965530500
Email: nickzhang@hangyubiotech.com
Country: China
ProdList: 8510
Advantage: 58

HANGZHOU LEAP CHEM CO., LTD.

Tel: +86-571-87711850
Email: market18@leapchem.com
Country: China
ProdList: 43339
Advantage: 58

Nanjing Doge Biomedical Technology Co., Ltd

Tel: +86-25-58227606 +86-15305155328
Email: sales@dogechemical.com
Country: China
ProdList: 4128
Advantage: 58

Shenzhen Lab Biotechnology Co., Ltd.

Tel: 13802209176
Country: CHINA
ProdList: 148
Advantage: 58

Guangzhou Kati Biotechnology Co., Ltd.

Tel: 13128698830
Country: CHINA
ProdList: 199
Advantage: 58

Guangzhou Weiran Biotechnology Co., Ltd

Tel: 18318703307
Country: CHINA
ProdList: 174
Advantage: 58

Guangzhou Bingheng Biotechnology Co., Ltd.

Tel: 13631342304
Country: CHINA
ProdList: 188
Advantage: 58

Guangzhou Jingyan Biotechnology Co., Ltd.

Tel: 13822277471
Country: CHINA
ProdList: 187
Advantage: 58

Neobioscience Co., Ltd.

Tel: --
Fax: --
Email: info@neobioscience.com
Country: CHINA
ProdList: 6207
Advantage: 58

Biorbyt Ltd.

Tel: --
Fax: --
Email: info@biorbyt.com
Country: CHINA
ProdList: 6482
Advantage: 58

Proteintech China

Tel: --
Fax: --
Email: Proteintech-CN@ptglab.com
Country: CHINA
ProdList: 6290
Advantage: 58

Shanghai Hao Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: shxiyuanbio@163.com
Country: CHINA
ProdList: 6906
Advantage: 58

Beijing Luyuan Bird Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 15810802415@139.com
Country: CHINA
ProdList: 6750
Advantage: 58

Hangzhou Lianke Biotechnology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6349
Advantage: 58

Shenzhen Branch Science and Technology Co., Ltd.

Tel: --
Fax: --
Email: zikerbio@163.com
Country: CHINA
ProdList: 6374
Advantage: 58

Beijing Dakco is Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: bj_info@dakewe.net
Country: CHINA
ProdList: 6580
Advantage: 58

921605-87-0, MF 438Related Search:

Geldanamycin CYCLOPAMINE Adapalene ZM 336372

MF 438

2-methyl-5-[6-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]pyridazin-3-yl]-1,3,4-thiadiazole

3-(5-Methyl-1,3,4-thiadiazol-2-yl)-6-[4-[2-(trifluoromethyl)phenoxy]-1-piperidinyl]pyridazine

Pyridazine, 3-(5-methyl-1,3,4-thiadiazol-2-yl)-6-[4-[2-(trifluoromethyl)phenoxy]-1-piperidinyl]-

3-(5-Methyl-1,3,4-thiadiazol-2-yl)-6-[4-[2-(trifluoromethyl)phenoxy]-1-piperidinyl]pyridazine(MF-438)

Stearoyl-CoA Desaturase (SCD),inhibit,MF438,MF 438,MF-438,Inhibitor

MF-438, 10 mM in DMSO

921605-87-0