MF 438
- Product Name
- MF 438
- CAS No.
- 921605-87-0
- Chemical Name
- MF 438
- Synonyms
- MF 438;MF-438, 10 mM in DMSO;Stearoyl-CoA Desaturase (SCD),inhibit,MF438,MF 438,MF-438,Inhibitor;3-(5-Methyl-1,3,4-thiadiazol-2-yl)-6-[4-[2-(trifluoromethyl)phenoxy]-1-piperidinyl]pyridazine;2-methyl-5-[6-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]pyridazin-3-yl]-1,3,4-thiadiazole;Pyridazine, 3-(5-methyl-1,3,4-thiadiazol-2-yl)-6-[4-[2-(trifluoromethyl)phenoxy]-1-piperidinyl]-;3-(5-Methyl-1,3,4-thiadiazol-2-yl)-6-[4-[2-(trifluoromethyl)phenoxy]-1-piperidinyl]pyridazine(MF-438)
- CBNumber
- CB52716285
- Molecular Formula
- C19H18F3N5OS
- Formula Weight
- 421.44
- MOL File
- 921605-87-0.mol
MF 438 Property
- Boiling point:
- 614.5±65.0 °C(Predicted)
- Density
- 1.365±0.06 g/cm3(Predicted)
- storage temp.
- -20°
- solubility
- Soluble in DMSO (up to 5 mg/ml) or in Ethanol (up to 2 mg/ml with warming).
- form
- solid
- pka
- 2.29±0.10(Predicted)
- color
- Off-white
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
N-Bromosuccinimide Price
- Product number
- CS-0009306
- Product name
- MF-438
- Purity
- 99.92%
- Packaging
- 5mg
- Price
- $250
- Updated
- 2021/12/16
- Product number
- CS-0009306
- Product name
- MF-438
- Purity
- 99.92%
- Packaging
- 10mg
- Price
- $380
- Updated
- 2021/12/16
- Product number
- CS-0009306
- Product name
- MF-438
- Purity
- 99.92%
- Packaging
- 50mg
- Price
- $1150
- Updated
- 2021/12/16
- Product number
- CS-0009306
- Product name
- MF-438
- Purity
- 99.92%
- Packaging
- 100mg
- Price
- $1650
- Updated
- 2021/12/16
- Product number
- 020466
- Product name
- MF-438
- Packaging
- 003
- Price
- $1800
- Updated
- 2021/12/16
MF 438 Chemical Properties,Usage,Production
Description
MF-438 (921605-87-0) is a potent inhibitor of stearoyl-CoA desaturase 1 (SCD1) – IC50?= 2.3 nM.1?MF-438 was potent in an?in vivo?mouse liver PD assay (ED50?between 1 and 3 mg/kg).1?Cancer initiating cells (CSC-like) were shown to be much more sensitive to MF-438 inhibition of SCD1 than progenitor and terminally differentiated cancer cells in a lung cancer model.2?MF-438 showed good oral bioavailability and metabolic stability making it an excellent tool for studying the effects of SCD1 in various disease models.
References
1) Leger?et al. (2010),?Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438); Bioorg. Med. Chem. Lett.,?20?499 2) Noto?et al. (2013),?Stearoyl-CoA desaturase-1 is a key factor for lung cancer-initiating cells; Cell Death and Differ.,?4?e947 3) Rodriguez-Perez?et al.?(2017),?Altered fatty acid metabolism and reduced stearoyl-coenzyme A desaturase activity in asthma; Allergy,?72?1744 [Citation]
MF 438 Preparation Products And Raw materials
Raw materials
Preparation Products
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