Bucladesine (calciuM salt)
- Product Name
- Bucladesine (calciuM salt)
- CAS No.
- 938448-87-4
- Chemical Name
- Bucladesine (calciuM salt)
- Synonyms
- DC2797 calcium salt;Bucladesine (calciuM salt);Dibutyryl-cAMP calcium salt;Bucladesine calcium (DC2797);Bucladesine calcium salt - Bio-X ?;Bucladesine (calciuM salt)，Bucladesinecalciumsalt
- CBNumber
- CB52735512
- Molecular Formula
- C18H26CaN5O8P
- Formula Weight
- 511.48
- MOL File
- 938448-87-4.mol
Bucladesine (calciuM salt) Property
- storage temp.
- Store at -20°C
- solubility
- Water: 100 mg/mL (204.74 mM); DMSO: ≥ 100 mg/mL (204.74 mM)
- form
- Solid
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- B689320
- Product name
- BucladesineCalciumSalt
- Packaging
- 50mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- CS-3558
- Product name
- Bucladesine(calcium)
- Purity
- 95.73%
- Packaging
- 50mg
- Price
- $78
- Updated
- 2021/12/16
- Product number
- CS-3558
- Product name
- Bucladesine(calcium)
- Purity
- 95.73%
- Packaging
- 100mg
- Price
- $96
- Updated
- 2021/12/16
- Product number
- NC11728
- Product name
- Bucladesine calcium salt
- Packaging
- 1g
- Price
- $105
- Updated
- 2021/12/16
- Product number
- NC11728
- Product name
- Bucladesine calcium salt
- Packaging
- 2g
- Price
- $160
- Updated
- 2021/12/16
Bucladesine (calciuM salt) Chemical Properties,Usage,Production
Uses
Bucladesine Calcium Salt is a cell-permeable cAMP analogue that activates cAMP dependent protein kinase (PKA) or the cAMP/PKA signaling pathway.
in vivo
Bucladesine (bilateral infusion of 10 mM or 100 mM) leads to a significant reduction in escape latency and travel distance (showing an improvement in spatial memory) compared to the control, as assesed by Morris water maze task in male rats. Bucladesine at 1 mM and 5 mM concentrations infused within minutes after 0.5 mg nicotine infusion improves spatial memory retention in male rats[1].
Bucladesine (10 mM/side) combined with Nicotine (0.5 mM/side) results in a significant increase in the ChAT and VAChT immunoreactivity in CA1 regions, and increase in the optical density and amount of ChAT and VAChT immunostaining correlates with the decrease in escape latency and traveled distance in rats treated with Nicotine and low dose of Bucladesine[2].
Bucladesine is absorbed very rapidly and almost completely when the aqueous solution is applied to the site where the skin has been excised. Bucladesine is absorbed rapidly but slower than in the full-thickness abrasion rat model in the case of stripped skin[3].
Bucladesine (single or multiple administration of an emulsion containing 1.5%) is capable of significantly reducing the inflammatory oedema in the arachidonic acid induced ear oedema model in mice[4].
IC 50
PKA; PDE
Bucladesine (calciuM salt) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Bucladesine (calciuM salt) manufacturers
- Product
- Bucladesine calcium salt 938448-87-4
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 90.0%Min. HPLC
- Supply Ability
- 1000kg
- Release date
- 2022-11-07