ChemicalBook > CAS DataBase List > 3-CHLORO-5-FLUOROPHENOL

3-CHLORO-5-FLUOROPHENOL

Product Name: 3-CHLORO-5-FLUOROPHENOL
CAS No.: 202982-70-5
Chemical Name: 3-CHLORO-5-FLUOROPHENOL
Synonyms: 3-CHLORO-5-FLUOROPHENOL;Phenol, 3-chloro-5-fluoro-;3-Chloro-5-fluorophenol98%;3-Chloro-5-fluorophenol 98%;Phenol, 3-chloro-5-fluoro- (9CI);3-Chloro-4-fluoro-α,α,α-trifluorotoluene;3-CHLORO-5-FLUOROPHENOL ISO 9001：2015 REACH
CBNumber: CB5273858
Molecular Formula: C6H4ClFO
Formula Weight: 146.55
MOL File: 202982-70-5.mol

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3-CHLORO-5-FLUOROPHENOL Property

Boiling point:: 206.0±20.0 °C(Predicted)
Density: 1.408±0.06 g/cm3(Predicted)
refractive index: 1.537
storage temp.: Inert atmosphere,Room Temperature
pka: 8.01±0.10(Predicted)
form: liquid
color: Clear
Water Solubility: Immiscible with water.
CAS DataBase Reference: 202982-70-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 20/21/22-36/37/38-22
Safety Statements: 26-36/37/39
RIDADR: UN3265
Hazard Note: Irritant
HazardClass: 8
HS Code: 2908190090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

H401Toxic to aquatic life

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC

Product number: C367185
Product name: 3-Chloro-5-fluorophenol
Packaging: 2.5g
Price: $120
Updated: 2021/12/16

TRC

Product number: C367185
Product name: 3-Chloro-5-fluorophenol
Packaging: 5g
Price: $195
Updated: 2021/12/16

Apolloscientific

Product number: PC8165
Product name: 3-Chloro-5-fluorophenol
Purity: 98%
Packaging: 1g
Price: $27
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2601-7-53
Product name: 3-Chloro-5-fluorophenol
Purity: 98%
Packaging: 1g
Price: $29
Updated: 2021/12/16

AK Scientific

Product number: V4194
Product name: 3-Chloro-5-fluorophenol
Packaging: 1g
Price: $83
Updated: 2021/12/16

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3-CHLORO-5-FLUOROPHENOL Chemical Properties,Usage,Production

Uses

3-Chloro-5-fluorophenol is used as an intermediate in organic synthesis. It plays an important role in the preparation of substituted amides as antagonists and/or inverse agonists of cannabinoid-1 receptor, substituted N-(arylmethyl)aryloxy arylcarboxamide and heteroarylcarboxamide antagonists for the PGE2 receptor EP4 for the treatment of pain, inflammation, osteoarthritis, and rheumatoid arthritis.

Synthesis

202925-08-4

202982-70-5

The general procedure for the synthesis of 3-chloro-5-fluorophenol from 1-chloro-3-fluoro-5-methoxybenzene was as follows: 3-chloro-5-fluoroanisole (10 g, 62 mmol) was dissolved in dichloromethane (50 mL) under argon protection and the solution was cooled to -70 °C. Boron tribromide (11.8 mL, 124 mmol) was slowly added dropwise at -70 °C under vigorous stirring, and the dropwise process was controlled to be completed within 15 minutes. Upon completion of the reaction, the mixture was gradually warmed to room temperature and the pH was adjusted with saturated sodium bicarbonate solution to 6. Subsequently, the organic and aqueous layers were separated, and the aqueous layer was extracted with dichloromethane (2 x 50 mL). All organic layers were combined, washed with saturated brine, dried over anhydrous sodium sulfate, and finally the solvent was evaporated under vacuum to afford the target product 3-chloro-5-fluorophenol (8 g, 88% yield, 54.6 mmol) as a yellow oil. The product was characterized by 1H NMR (DMSO-d6): δ 10.36 (s, 1H, OH), 6.73-6.79 (m, 1H, Ar-H), 6.64-6.68 (m, 1H, Ar-H), 6.53-6.59 (m, 1H, Ar-H).

References

[1] Patent: WO2006/136924, 2006, A1. Location in patent: Page/Page column 133

3-CHLORO-5-FLUOROPHENOL Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-CHLORO-5-FLUOROPHENOL manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 3-Chloro-5-fluorophenol 202982-70-5
Price: US $2.00-5.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-23

Career Henan Chemical Co

Product: 3-CHLORO-5-FLUOROPHENOL 202982-70-5
Price: US $2.00/KG
Min. Order: 1g
Purity: 98%MIN
Supply Ability: ASK
Release date: 2020-01-07

Career Henan Chemical Co

Product: 1H-Imidazole-4-carboxaldehyde, 5-(1,1-dimethylethyl)- (9CI) 202982-70-5
Price: US $2.00/KG
Min. Order: 1g
Purity: 98%MIN
Supply Ability: ASK
Release date: 2020-01-07

202982-70-5, 3-CHLORO-5-FLUOROPHENOLRelated Search:

3-CHLORO-5-FLUOROANISOLE 3-CHLORO-5-FLUOROPHENOL 4-CHLORO-3-FLUOROPHENOL,4-Chloro-3-fluorophenol 98%,4-Chloro-3-fluorophenol,98% 3-CHLORO-2-FLUOROPHENOL 4-CHLORO-2-FLUOROPHENOL,4-Chloro-2-fluorophenol, 98+%,4-Chloro-2-fluorophenol 99%,4-Chloro-2-fluorophenol99% 2,6-DICHLORO-4-FLUOROPHENOL 4-BROMO-2-CHLORO-6-FLUOROPHENOL,4-Bromo-2-chloro-6-fluorophenol 97% 2-Chloro-5-fluorophenol98%,2-Chloro-5-fluorophenol, min. 97%,2-Chloro-5-fluorophenol 98%,2-Chloro-5-fluorophenol,min.97%,2-CHLORO-5-FLUOROPHENOL 2-CHLORO-6-FLUOROPHENOL,2-Chloro-6-fluorophenol, 97+% 3-Chloro-4-fluorophenol 98%,3-CHLORO-4-FLUOROPHENOL,3-Chloro-4-fluorophenol98% 2,3-DICHLORO-6-FLUOROPHENOL 2-CHLORO-4-FLUOROPHENOL,2-Chloro-4-fluorophenol 99%,2-Chloro-4-fluorophenol, 98+%,2-Chloro-4-fluorophenol99% Phenol, 4-amino-2-chloro-3-fluoro- 2-BROMO-4-CHLORO-6-FLUOROPHENOL 2-CHLORO-3-FLUOROPHENOL 2-BROMO-6-CHLORO-4-FLUOROPHENOL 3-CHLORO-5-FLUOROPHENETOLE 5-AMINO-2-CHLORO-4-FLUOROPHENOL

Phenol, 3-chloro-5-fluoro- (9CI)

3-Chloro-5-fluorophenol 98%

3-Chloro-5-fluorophenol98%

3-CHLORO-5-FLUOROPHENOL

Phenol, 3-chloro-5-fluoro-

3-CHLORO-5-FLUOROPHENOL ISO 9001：2015 REACH

3-Chloro-4-fluoro-α,α,α-trifluorotoluene

202982-70-5

ALCOHOL

HALIDE

Aromatic Phenols

Phenol&Thiophenol&Mercaptan

Chlorine Compounds

Fluorine Compounds

Phenols