3-CHLORO-5-FLUOROPHENOL
- Product Name
- 3-CHLORO-5-FLUOROPHENOL
- CAS No.
- 202982-70-5
- Chemical Name
- 3-CHLORO-5-FLUOROPHENOL
- Synonyms
- 3-CHLORO-5-FLUOROPHENOL;Phenol, 3-chloro-5-fluoro-;3-Chloro-5-fluorophenol98%;3-Chloro-5-fluorophenol 98%;Phenol, 3-chloro-5-fluoro- (9CI);3-Chloro-4-fluoro-α,α,α-trifluorotoluene;3-CHLORO-5-FLUOROPHENOL ISO 9001：2015 REACH
- CBNumber
- CB5273858
- Molecular Formula
- C6H4ClFO
- Formula Weight
- 146.55
- MOL File
- 202982-70-5.mol
3-CHLORO-5-FLUOROPHENOL Property
- Boiling point:
- 206.0±20.0 °C(Predicted)
- Density
- 1.408±0.06 g/cm3(Predicted)
- refractive index
- 1.537
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 8.01±0.10(Predicted)
- form
- liquid
- color
- Clear
- Water Solubility
- Immiscible with water.
- CAS DataBase Reference
- 202982-70-5(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 20/21/22-36/37/38-22
- Safety Statements
- 26-36/37/39
- RIDADR
- UN3265
- Hazard Note
- Irritant
- HazardClass
- 8
- HS Code
- 2908190090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H314Causes severe skin burns and eye damage
H318Causes serious eye damage
H401Toxic to aquatic life
H411Toxic to aquatic life with long lasting effects
- Precautionary statements
-
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- C367185
- Product name
- 3-Chloro-5-fluorophenol
- Packaging
- 2.5g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- C367185
- Product name
- 3-Chloro-5-fluorophenol
- Packaging
- 5g
- Price
- $195
- Updated
- 2021/12/16
- Product number
- V4194
- Product name
- 3-Chloro-5-fluorophenol
- Packaging
- 5g
- Price
- $151
- Updated
- 2021/12/16
- Product number
- PC8165
- Product name
- 3-Chloro-5-fluorophenol
- Purity
- 98%
- Packaging
- 25g
- Price
- $296
- Updated
- 2021/12/16
- Product number
- 2601-7-53
- Product name
- 3-Chloro-5-fluorophenol
- Purity
- 98%
- Packaging
- 25g
- Price
- $327
- Updated
- 2021/12/16
3-CHLORO-5-FLUOROPHENOL Chemical Properties,Usage,Production
Uses
3-Chloro-5-fluorophenol is used as an intermediate in organic synthesis. It plays an important role in the preparation of substituted amides as antagonists and/or inverse agonists of cannabinoid-1 receptor, substituted N-(arylmethyl)aryloxy arylcarboxamide and heteroarylcarboxamide antagonists for the PGE2 receptor EP4 for the treatment of pain, inflammation, osteoarthritis, and rheumatoid arthritis.
Synthesis
202925-08-4
202982-70-5
The general procedure for the synthesis of 3-chloro-5-fluorophenol from 1-chloro-3-fluoro-5-methoxybenzene was as follows: 3-chloro-5-fluoroanisole (10 g, 62 mmol) was dissolved in dichloromethane (50 mL) under argon protection and the solution was cooled to -70 °C. Boron tribromide (11.8 mL, 124 mmol) was slowly added dropwise at -70 °C under vigorous stirring, and the dropwise process was controlled to be completed within 15 minutes. Upon completion of the reaction, the mixture was gradually warmed to room temperature and the pH was adjusted with saturated sodium bicarbonate solution to 6. Subsequently, the organic and aqueous layers were separated, and the aqueous layer was extracted with dichloromethane (2 x 50 mL). All organic layers were combined, washed with saturated brine, dried over anhydrous sodium sulfate, and finally the solvent was evaporated under vacuum to afford the target product 3-chloro-5-fluorophenol (8 g, 88% yield, 54.6 mmol) as a yellow oil. The product was characterized by 1H NMR (DMSO-d6): δ 10.36 (s, 1H, OH), 6.73-6.79 (m, 1H, Ar-H), 6.64-6.68 (m, 1H, Ar-H), 6.53-6.59 (m, 1H, Ar-H).
References
[1] Patent: WO2006/136924, 2006, A1. Location in patent: Page/Page column 133
3-CHLORO-5-FLUOROPHENOL Preparation Products And Raw materials
Raw materials
Preparation Products
3-CHLORO-5-FLUOROPHENOL Suppliers
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- Country
- Germany
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View Lastest Price from 3-CHLORO-5-FLUOROPHENOL manufacturers
- Product
- 3-Chloro-5-fluorophenol 202982-70-5
- Price
- US $2.00-5.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-23
- Product
- 3-CHLORO-5-FLUOROPHENOL 202982-70-5
- Price
- US $2.00/KG
- Min. Order
- 1g
- Purity
- 98%MIN
- Supply Ability
- ASK
- Release date
- 2020-01-07
- Product
- 1H-Imidazole-4-carboxaldehyde, 5-(1,1-dimethylethyl)- (9CI) 202982-70-5
- Price
- US $2.00/KG
- Min. Order
- 1g
- Purity
- 98%MIN
- Supply Ability
- ASK
- Release date
- 2020-01-07