MCC950

Product Name: MCC950
CAS No.: 210826-40-7
Chemical Name: MCC950
Synonyms: CP-456773;CRID3;CRID 3;MCC950;CRID-3;CS-2292;CAS:210826-40-7;MCC950 (MCC-950;MCC950, 10 mM in DMSO;MCC950 (Synonyms: CP-456773
CBNumber: CB52744215
Molecular Formula: C20H24N2O5S
Formula Weight: 404.48
MOL File: 210826-40-7.mol

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MCC950 Property

Melting point:: 239 °C
Density: 1.396±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO (up to 40 mg/ml) or in Water (up to 30 mg/ml)
pka: 4.74±0.10(Predicted)
form: solid
color: White
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
InChI: InChI=1S/C20H24N2O5S/c1-20(2,24)14-10-17(27-11-14)28(25,26)22-19(23)21-18-15-7-3-5-12(15)9-13-6-4-8-16(13)18/h9-11,24H,3-8H2,1-2H3,(H2,21,22,23)
InChIKey: HUUSXLKCTQDPGL-UHFFFAOYSA-N
SMILES: O1C=C(C(O)(C)C)C=C1S(NC(NC1=C2C(=CC3CCCC1=3)CCC2)=O)(=O)=O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H303May be harmfulif swallowed

H320Causes eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 17510
Product name: MCC950
Purity: ≥98%
Packaging: 1mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 17510
Product name: MCC950
Purity: ≥98%
Packaging: 5mg
Price: $336
Updated: 2024/03/01

Cayman Chemical

Product number: 17510
Product name: MCC950
Purity: ≥98%
Packaging: 10mg
Price: $593
Updated: 2024/03/01

Cayman Chemical

Product number: 17510
Product name: MCC950
Purity: ≥98%
Packaging: 25mg
Price: $1184
Updated: 2024/03/01

TRC

Product number: M199775
Product name: MCC-950
Packaging: 10mg
Price: $425
Updated: 2021/12/16

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MCC950 Chemical Properties,Usage,Production

Description

MCC-950 (210826-40-7) was originally found to act as a cytokine release inhibitory drug (CRID), arresting activated monocytes and preventing activation of caspase-1.1?Discovered to be a novel inhibitor of the NLRP3 and AIM2 inflammasomes.2?MCC-950 blocks canonical and noncanonical NLRP3 activation at nanomolar concentrations.3?Inhibits interleukin 1β (IL-1β) secretion?in vivo?and attenuates the severity of experimental autoimmune encephalomyelitis (an MS disease model).3?Disrupts the interaction between AIM2 and ASC in a reconstituted cell-free inflammasome.4?MCC-950 is a valuable new tool for exploring the pathophysiology of NLRP3.

Uses

MCC950 selectively inhibits pyrin domain-containing protein 3 (NLRP3) inflammasome, a protein complex involved in the inflammatory process (1). The NLRP3 inflammasome is related to a wide range of immune disorders such as multiple sclerosis, inflammatory bowel disease, auto-immune and auto-inflammatory diseases (2). MCC950 has been shown to specifically inhibit the activation of NLRP3 but not the AIM2, NLRC4 or NLRP1 inflammasomes (1). MCC950 is a potential therapeutic for NLRP3-associated syndromes.

in vivo

MCC950 reduces Interleukin-1p (IL-1β) production and attenuates the severity of experimental autoimmune encephalomyelitis (EAE), a disease model of multiple sclerosis. Pre-treatment with MCC950 reduces serum concentrations of IL-1β and IL-6 while it does not considerably decrease the amount of TNF-α. Treatment of mice with MCC950 delays the onset and reduced the severity of EAE. Intracellular cytokine staining and FACS analysis of brain mononuclear cells from mice sacrificed on day 22 shows modestly reduced frequencies of IL-17 and IFN-γ producing CD3⁺ T cells in MCC950 treated mice in comparison with PBS-treated mice. IFN-γ and particularly IL-17 producing cell numbers are also reduced in both the CD4⁺ and γδ⁺ sub-populations of CD3⁺ T cells^[1].

IC 50

NLRP3

References

[1] RONALD E LALIBERTE. Glutathione s-transferase omega 1-1 is a target of cytokine release inhibitory drugs and may be responsible for their effect on interleukin-1beta posttranslational processing.[J]. The Journal of Biological Chemistry, 2003, 278 19: 16567-16578. DOI:10.1074/jbc.m211596200
[2] REBECCA C COLL. The cytokine release inhibitory drug CRID3 targets ASC oligomerisation in the NLRP3 and AIM2 inflammasomes.[J]. PLoS ONE, 2011: e29539. DOI:10.1371/journal.pone.0029539
[3] REBECCA C COLL. A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases[J]. Nature Medicine, 2015, 21 3: 248-255. DOI:10.1038/nm.3806
[4] NAOE KANEKO . Reconstituted AIM2 inflammasome in cell-free system[J]. Journal of immunological methods, 2015, 426: Pages 76-81. DOI:10.1016/j.jim.2015.08.004

MCC950 Preparation Products And Raw materials

Raw materials

Preparation Products

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MCC950 Suppliers

China 122 United States 14 Global 136

Biokitchen

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CRID 3

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MCC950, 10 mM in DMSO

CAS:210826-40-7

MCC950 (Synonyms: CP-456773

210826-40-7

21086-40-7