Lampalizumab

Product Name: Lampalizumab
CAS No.: 1278466-20-8
Chemical Name: Lampalizumab
Synonyms: Lampalizumab;Research Grade Lampalizumab;Lampalizumab (anti-Complement Factor D);Research Grade Lampalizumab (DHB88001)
CBNumber: CB52744220
Formula Weight: 0
MOL File: Mol file

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Lampalizumab Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Lampalizumab Chemical Properties,Usage,Production

Uses

Lampalizumab (RG 7417) is a humanised monoclonal antibody targeting complement Factor D in the alternative complement pathway. Lampalizumab binds an exosite and sterically blocks Factor B access to the active site. Lampalizumab can be used for age-related macular degeneration (AMD) research[1][2].

in vivo

Lampalizumab delivered intravenously to cynomolgus monkeys elicits nearly 10-fold increases in serum Factor D levels within five hours, effectively neutralizing its inhibitory activity^[1].

References

[1] Yuan X, et al. Small-molecule factor D inhibitors selectively block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome. Haematologica. 2017 Mar;102(3):466-475. DOI:10.3324/haematol.2016.153312
[2] Hanus J, et al. Current therapeutic developments in atrophic age-related macular degeneration. Br J Ophthalmol. 2016 Jan;100(1):122-7. DOI:10.1136/bjophthalmol-2015-306972

Lampalizumab Preparation Products And Raw materials

Raw materials

Preparation Products

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Lampalizumab Suppliers

China 13 Global 13

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1278466-20-8, LampalizumabRelated Search:

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Lampalizumab

Research Grade Lampalizumab (DHB88001)

Research Grade Lampalizumab

Lampalizumab (anti-Complement Factor D)

1278466-20-8