6-CYANONICOTINIC ACID

Product Name: 6-CYANONICOTINIC ACID
CAS No.: 70165-31-0
Chemical Name: 6-CYANONICOTINIC ACID
Synonyms: 6-Cyanonicotinicaci;6-CYANONICOTINIC ACID;6-Cuanonicotinic acid;5-carboxypicolinonitrile;2-CYANO-5-CARBOXYPYRIDINE;6-Cyanonicotinic acid ,97%;6-Cyanonicotinic acid 95+%;N-(Pyridin-3-ylmethyl)ethanamine;3-Pyridinecarboxylicacid,6-cyano-;6-Cyano-pyridin-3-carboxylic acid
CBNumber: CB5278530
Molecular Formula: C7H4N2O2
Formula Weight: 148.12
MOL File: 70165-31-0.mol

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6-CYANONICOTINIC ACID Property

Melting point:: 190-194 °C(lit.)
Boiling point:: 395.9±27.0 °C(Predicted)
Density: 1.42±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: Soluble in alcohol.
form: Oil
pka: 2.81±0.10(Predicted)
color: Clear Yellow
BRN: 4384027
CAS DataBase Reference: 70165-31-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-36/37/38
Safety Statements: 26-36
RIDADR: 3439
WGK Germany: 3
Hazard Note: Harmful
HazardClass: 6.1
PackingGroup: III
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 656429
Product name: 6-Cyanopyridine-3-carboxylic acid
Purity: 97%
Packaging: 1g
Price: $194
Updated: 2025/07/31

TRC

Product number: C998373
Product name: 6-CyanonicotinicAcid
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC44821
Product name: 6-Cyanonicotinic acid
Packaging: 500mg
Price: $135
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H37-1-X1
Product name: 6-Cyanonicotinic acid
Packaging: 1g
Price: $141
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC44821
Product name: 6-Cyanonicotinic acid
Packaging: 1g
Price: $215
Updated: 2021/12/16

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6-CYANONICOTINIC ACID Chemical Properties,Usage,Production

Uses

6-Cyanonicotinic acid, is used in medicine

Synthesis

2398-81-4

143-33-9

70165-31-0

The general procedure for the synthesis of 6-cyanonicotinic acid from oxonicotinic acid and sodium cyanide was as follows: to a 1.2 L DMF solution of oxonicotinic acid N-oxide (51 g, 0.37 mol) was added sodium cyanide (54 g, 1.1 mol), triethylamine (255 mL, 1.83 mol), and trimethylchlorosilane (185 mL). The reaction mixture was stirred at 110 °C for 10 h. After completion of the reaction, filtration was performed and the filtrate was concentrated. The residue was dissolved in 100 mL of 2N hydrochloric acid and extracted with dichloromethane. The organic layers were combined, concentrated and recrystallized from water to give 12 g (22% yield) of 6-cyanonicotinic acid.

References

[1] Synthesis, 1983, # 4, p. 316 - 319
[2] Chemical Communications, 2004, # 15, p. 1770 - 1771
[3] Patent: WO2003/101956, 2003, A1. Location in patent: Page 113; 114
[4] Bioorganic and Medicinal Chemistry Letters, 2000, vol. 10, # 4, p. 385 - 389

6-CYANONICOTINIC ACID Preparation Products And Raw materials

Raw materials

Nicotinic acid 1-Cbz-Piperidin-4-ylidene-acetic acid Chlorotrimethylsilane Sodium borohydride Triethylamine N,N-Diethylformamide Sodium cyanide Acetic acid

Preparation Products

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6-CYANONICOTINIC ACID Suppliers

Canada 1 China 118 Europe 1 Germany 3 India 4 Switzerland 1 United Kingdom 10 United States 17 Global 155

Alchem Pharmtech,Inc.

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View Lastest Price from 6-CYANONICOTINIC ACID manufacturers

Dideu Industries Group Limited

Product: 6-CYANONICOTINIC ACID 70165-31-0
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-10-26

Zhuozhou Wenxi import and Export Co., Ltd

Product: 6-CYANONICOTINIC ACID 70165-31-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 6-CYANONICOTINIC ACID 70165-31-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

70165-31-0, 6-CYANONICOTINIC ACIDRelated Search:

2-CHLOROPYRIDINE-5-ACETIC ACID ETHYL ESTER 3-(3-PYRIDYL)ACRYLIC ACID 2-CYANO-3-PYRIDINECARBOXYLIC ACID METHYL ESTER Nicotinic acid 5-BROMO-2-CYANONICOTINIC ACID 6-CYANO-5-FLUORO-2-METHOXYNICOTINIC ACID 5-BROMO-6-CYANO-NICOTINIC ACID 6-CYANO-2-METHOXYNICOTINIC ACID METHYL 6-CYANO-2-METHYLNICOTINATE 6-CYANONICOTINIC ACID 2-CYANO-5-ETHOXYCARBONYLPYRIDINE

2-CYANO-5-CARBOXYPYRIDINE

6-CYANONICOTINIC ACID

6-CYANOPYRIDINE-3-CARBOXYLIC ACID

5-Carboxypicolinonitrile~2-Cyano-5-carboxypyridine~6-Cyanopyridine-3-carboxylic acid

5-carboxypicolinonitrile

6-Cyanonicotinic acid ,97%

3-Pyridinecarboxylicacid,6-cyano-(9CI)

N-(Pyridin-3-ylmethyl)ethanamine

3-Pyridinecarboxylicacid,6-cyano-

6-Cyanopyridine-3-carboxylic acid, 5-Carboxypicolinonitrile

6-Cyano-pyridin-3-carboxylic acid

6-Cyanopyridine-3-carboxylic acid, 5-Carboxy-2-cyanopyridine, 5-Carboxypicolinonitrile

6-Cyanopyridine-3-carboxylic acid 97%

6-Cyanonicotinic acid 95+%

6-Cyano-3-pyridinecarboxylic Acid

6-Cyanonicotinicaci

2-cyano-pyridine-5-carboxylic acid

6-CYANONICOTINIC ACID ISO 9001：2015 REACH

6-Cuanonicotinic acid

70165-31-0

C7 and C8

Building Blocks

Heterocyclic Building Blocks

Pyridines

CARBOXYLICACID

NITRILE