POLYGODIAL
- Product Name
- POLYGODIAL
- CAS No.
- 6754-20-7
- Chemical Name
- POLYGODIAL
- Synonyms
- Poligodial;POLYGODIAL;(-)-Tadeonal;Polygodial (Tadeonal);Drim-7-ene-11,12-dial;1,4,4A,5,6,7,8,8A-Octahydro-5,5,8A-trimethyl-1,2-naphthalenedicarboxaldehyde;(1R,4aS,8aS)-1,4,4a,5,6,7,8,8a-Octahydro-5,5,8a-trimethyl-1,2-naphthalenedicarboxaldehyde;1,2-Naphthalenedicarboxaldehyde, 1alpha,4,4aalpha,5,6,7,8,8A-octahydro-5,5,8abata-trimethyl-;1,2-Naphthalenedicarboxaldehyde, 1,4,4a,5,6,7,8,8a-octahydro-5,5,8a-trimethyl-, (1R,4aS,8aS)-;1,2-Naphthalenedicarboxaldehyde, 1,4,4A,5,6,7,8,8A-octahydro-5,5,8A-trimethyl-, (2R,4as,8as)-
- CBNumber
- CB5284348
- Molecular Formula
- C15H22O2
- Formula Weight
- 234.33
- MOL File
- 6754-20-7.mol
POLYGODIAL Property
- Melting point:
- 57° (Barnes, Loder)
- alpha
- D24 -131° (c = 0.96 in ethanol)
- Boiling point:
- 330.7±35.0 °C(Predicted)
- Density
- 1.084±0.06 g/cm3(Predicted)
- RTECS
- QJ2850000
- storage temp.
- -20°C
- solubility
- DMSO: soluble20mg/mL, clear
- form
- powder
- color
- white to beige
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
- LogP
- 3.522 (est)
N-Bromosuccinimide Price
- Product number
- SML0049
- Product name
- Polygodial
- Purity
- ≥97% (HPLC)
- Packaging
- 10mg
- Price
- $195
- Updated
- 2024/03/01
- Product number
- SML0049
- Product name
- Polygodial
- Purity
- ≥97% (HPLC)
- Packaging
- 50mg
- Price
- $759
- Updated
- 2024/03/01
- Product number
- J67380
- Product name
- Polygodial, 97%
- Packaging
- 5mg
- Price
- $158
- Updated
- 2021/12/16
- Product number
- 14979
- Product name
- Polygodial
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 14979
- Product name
- Polygodial
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $93
- Updated
- 2024/03/01
POLYGODIAL Chemical Properties,Usage,Production
Description
Polygodial (6754-20-7) is a TRPA1 activator (EC50=400 nM).1?A naturally occurring drimane sesquiterpene dialdehyde found in a variety of plant species including water pepper (Polygonum hydropiper). Polygodial has been used in folk medicine for a variety of indications. Displays analgesic activity via desensitization of sensory neurons.2
Uses
Polygodial is a naturally occurring antifungal and antinociceptive.
Definition
ChEBI: Polygodial is an aldehyde.
Biochem/physiol Actions
Polygodial is a selective activator of Transient Receptor Potential Anykrin 1 (TRPA1) channels. Initially painful, polygodial acts as an analgesic by desensitizing sensory neuron. Polygodial also has broad antifungal properties, and is cytotoxic against bacteria and algae.
storage
Store at -20°C
References
1) Escalera et al. (2008), TRPA1 mediates the noxious effects of natural sesquiterpene deterrents; J. Biol. Chem., 283 24136 2) Andre et al. (2004), Evidence for the involvement of vanilloid receptor in the antinociception produced by the dialdehydes unsaturated sesquiterpenes polygodial and drimanial in rats; Neuropharmacology, 46 590