ChemicalBook > CAS DataBase List > 3-HYDROXY-6-METHYL-2-NITROPYRIDINE

3-HYDROXY-6-METHYL-2-NITROPYRIDINE

Product Name: 3-HYDROXY-6-METHYL-2-NITROPYRIDINE
CAS No.: 15128-90-2
Chemical Name: 3-HYDROXY-6-METHYL-2-NITROPYRIDINE
Synonyms: 6-METHYL-2-NITRO-3-PYRIDINOL;5-hydroxy-6-nitro-2-picoline;6-methyl-2-nitropyridin-3-ol;3-Hydroxy-2-nitro-6-picoline;3-Pyridinol, 6-methyl-2-nitro-;6-methyl-2-nitro-3-pyridinolate;5-HYDROXY-2-METHYL-6-NITROPYRIDINE;6-METHYL-2-NITRO-3-HYDROXYPYRIDINE;3-HYDROXY-6-METHYL-2-NITROPYRIDINE;3-HYDROXY-6-METHYL-2-NITROPYRIDINE 99%
CBNumber: CB5288508
Molecular Formula: C6H6N2O3
Formula Weight: 154.12
MOL File: 15128-90-2.mol

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3-HYDROXY-6-METHYL-2-NITROPYRIDINE Property

Melting point:: 106-107 °C (lit.)
Boiling point:: 277.46°C (rough estimate)
Density: 1.4564 (rough estimate)
refractive index: 1.5100 (estimate)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: powder to crystal
pka: 1.01±0.22(Predicted)
color: Light orange to Yellow to Green
BRN: 974751
InChI: InChI=1S/C6H6N2O3/c1-4-2-3-5(9)6(7-4)8(10)11/h2-3,9H,1H3
InChIKey: WZMGQHIBXUAYGS-UHFFFAOYSA-N
SMILES: C1([N+]([O-])=O)=NC(C)=CC=C1O
CAS DataBase Reference: 15128-90-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39-36
WGK Germany: 3
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 232742
Product name: 3-Hydroxy-6-methyl-2-nitropyridine
Purity: 99%
Packaging: 10g
Price: $143
Updated: 2023/01/07

Sigma-Aldrich

Product number: 232742
Product name: 3-Hydroxy-6-methyl-2-nitropyridine
Purity: 99%
Packaging: 50g
Price: $492
Updated: 2023/01/07

TCI Chemical

Product number: H0762
Product name: 3-Hydroxy-6-methyl-2-nitropyridine
Purity: >98.0%(GC)
Packaging: 5g
Price: $39
Updated: 2025/07/31

TCI Chemical

Product number: H0762
Product name: 3-Hydroxy-6-methyl-2-nitropyridine
Purity: >98.0%(GC)
Packaging: 25g
Price: $187
Updated: 2025/07/31

TRC

Product number: H949525
Product name: 3-Hydroxy-6-methyl-2-nitropyridine
Packaging: 25g
Price: $305
Updated: 2021/12/16

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3-HYDROXY-6-METHYL-2-NITROPYRIDINE Chemical Properties,Usage,Production

Chemical Properties

yellow fine crystalline powder

Uses

3-Hydroxy-6-methyl-2-nitropyridine was used in the synthesis of 3-methoxy-6-methyl-2-nitropyridine.Molecular structure and corresponding vibrational assignments of 3-hydroxy-6-methyl-2-nitropyridine have been investigated using density functional theory (DFT).

General Description

Molecular structure and corresponding vibrational assignments of 3-hydroxy-6-methyl-2-nitropyridine have been investigated using density functional theory (DFT).

Synthesis

1121-78-4

15128-90-2

General procedure for the synthesis of 3-hydroxy-6-methyl-2-nitropyridine from 3-hydroxy-6-methylpyridine: 3-hydroxy-6-methylpyridine (23.6 g, 216 mmol) was dissolved in concentrated sulfuric acid (50 mL) and cooled to 0 °C. Fuming nitric acid (50 mL) was added slowly over a period of 1 hour. The reaction mixture was stirred at room temperature for 1 hour and then poured into ice (400 g) and the precipitate was collected by filtration. The resulting solid was dissolved in ethyl acetate and the organic layer was washed with brine (100 mL). The organic phase was dried over anhydrous magnesium sulfate and the solvent was evaporated under reduced pressure to give 12.1 g of the title compound (36.3% yield). The melting point of the product was 102-105 °C. 1H NMR (DMSO-d6, 300 MHz) δ: 2.44 (s, 3H), 7.52 (d, J = 8.5 Hz, 1H), 7.58 (d, J = 8.5 Hz, 1H). Mass spectrum (ESI-Q1MS) m/e 153 (M-H)+. Elemental analysis calculated values (C6H6N3O3): C, 46.76; H, 3.92; N, 18.18. Measured values: C, 46.65; H, 3.98; N, 18.10.

References

[1] Heterocycles, 1994, vol. 38, # 3, p. 529 - 540
[2] Journal of Medicinal Chemistry, 1987, vol. 30, # 11, p. 2031 - 2046
[3] Patent: US6133253, 2000, A
[4] Patent: US5155116, 1992, A
[5] Patent: US5084456, 1992, A

3-HYDROXY-6-METHYL-2-NITROPYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-HYDROXY-6-METHYL-2-NITROPYRIDINE Suppliers

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View Lastest Price from 3-HYDROXY-6-METHYL-2-NITROPYRIDINE manufacturers

Dideu Industries Group Limited

Product: 3-HYDROXY-6-METHYL-2-NITROPYRIDINE 15128-90-2
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-09-24

Career Henan Chemical Co

Product: 3-HYDROXY-6-METHYL-2-NITROPYRIDINE 15128-90-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-01-09

15128-90-2, 3-HYDROXY-6-METHYL-2-NITROPYRIDINERelated Search:

5-BROMO-2-HYDROXY-3-NITRO-4-PICOLINE 3-Hydroxypyridine 2-Hydroxy-4-methyl-5-nitropyridine 2-Hydroxy-6-methyl-5-nitropyridine 2-Hydroxy-5-methyl-3-nitropyridine 2-HYDROXY-3-METHYL-5-NITROPYRIDINE 6-Hydroxy-5-nitro-2-picoline 2-Hydroxy-4-methyl-3-nitropyridine 2-HYDROXY-4-METHYL-5-NITROPYRIDINE 98+%,2-HYDROXY-4-METHYL-5-NITROPYRIDINE 98+% 2-HYDROXY-5-NITRO-3-PICOLINE (2-HYDROXY-3-METHYL-5-NITROPYRIDINE),2-HYDROXY-5-NITRO-3-PICOLINE (2-HYDROXY-3-METHYL-5-NITROPYRIDINE) 6-METHYL-2-NITRO-3-PYRIDYL 2-CHLORONICOTINATE 6-METHYL-2-NITRO-3-PYRIDYL TRIFLUOROMET& 3-Methoxy-2-Nitro-6-Picoline 3-HYDROXY-6-METHYL-2-NITROPYRIDINE 6-METHYL-2-NITRO-3-PYRIDYL 5-CHLORO-1,3-DIMETHYL-1H-PYRAZOLE-4-SULFONATE 2-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOXYLIC ACID, 6-METHYL-2-NITROPYRIDIN-3-YL ESTER

3-Pyridinol, 6-methyl-2-nitro-

3-Hydroxy-2-nitro-6-picoline

3-Hydroxy-6-methyl-2-nitropyridine,6-Methyl-2-nitro-3-pyridinol

3-HYDROXY-6-METHYL-2-NITROPYRIDINE

6-METHYL-2-NITRO-3-HYDROXYPYRIDINE

6-METHYL-2-NITRO-3-PYRIDINOL

5-HYDROXY-2-METHYL-6-NITROPYRIDINE

6-methyl-2-nitropyridin-3-ol

5-hydroxy-6-nitro-2-picoline

3-HYDROXY-6-METHYL-2-NITROPYRIDINE 99%

3-HYDROXY-2-NITRO-6-PICOLINE (3-HYDROXY-6-METHYL-2-NITROPYRIDINE)

3-Hydroxy-6-methyl-2-nitropyridine,99%

6-methyl-2-nitro-3-pyridinolate

3-HYDROXY-6-METHYL-2-NITROPYRIDINE ISO 9001：2015 REACH

15128-90-2

Heterocyclic Building Blocks

Pyridines

Building Blocks

Pyridine

Pyridines, Pyrimidines, Purines and Pteredines