ChemicalBook > CAS DataBase List > 1,4-PHENYLENE DIISOTHIOCYANATE

1,4-PHENYLENE DIISOTHIOCYANATE

Product Name
1,4-PHENYLENE DIISOTHIOCYANATE
CAS No.
4044-65-9
Chemical Name
1,4-PHENYLENE DIISOTHIOCYANATE
Synonyms
DITC;PDITC;Jonit;16842;WM 842;Biscomate;jonit[qr];wm842[qr];Bitoscanat;BITOSCANATE
CBNumber
CB5292882
Molecular Formula
C8H4N2S2
Formula Weight
192.26
MOL File
4044-65-9.mol
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1,4-PHENYLENE DIISOTHIOCYANATE Property

Melting point:
129-131 °C (lit.)
Boiling point:
339.4±25.0 °C(Predicted)
Density 
1.3675 (rough estimate)
refractive index 
1.6000 (estimate)
storage temp. 
−20°C
solubility 
chloroform: clear
form 
powder
color 
white
Water Solubility 
Hydrolyzes in water.
Sensitive 
Moisture Sensitive
Merck 
14,1308
BRN 
2414340
InChIKey
OMWQUXGVXQELIX-UHFFFAOYSA-N
CAS DataBase Reference
4044-65-9(CAS DataBase Reference)
EPA Substance Registry System
Bitoscanate (4044-65-9)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38-42
Safety Statements 
22-26-36/37
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
NX9150000
10-21
Hazard Note 
Irritant
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
II
HS Code 
29291090
Hazardous Substances Data
4044-65-9(Hazardous Substances Data)
Toxicity
LD50 oral in mouse: 230mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
258555
Product name
p-Phenylene diisothiocyanate
Purity
98%
Packaging
1g
Price
$24.48
Updated
2024/03/01
Sigma-Aldrich
Product number
258555
Product name
p-Phenylene diisothiocyanate
Purity
98%
Packaging
5g
Price
$143
Updated
2024/03/01
TCI Chemical
Product number
P1279
Product name
1,4-Phenylene Diisothiocyanate
Purity
>98.0%(GC)
Packaging
5g
Price
$112
Updated
2024/03/01
TCI Chemical
Product number
P1279
Product name
1,4-Phenylene Diisothiocyanate
Purity
>98.0%(GC)
Packaging
25g
Price
$384
Updated
2024/03/01
Alfa Aesar
Product number
L09756
Product name
1,4-Phenylene diisothiocyanate, 98%
Packaging
1g
Price
$34.65
Updated
2024/03/01
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1,4-PHENYLENE DIISOTHIOCYANATE Chemical Properties,Usage,Production

Description

Bitoscanate is a colorless to beige, odorless,crystalline compound. Molecular weight=192.3; Freezing/Melting point=132℃. Hazard Identification (based onNFPA-704 M Rating System): Health 2, Flammability 1,Reactivity 0.

Chemical Properties

Those engaged in the manufacture, formulation and application of this anthelmintic compound. Incompatibilities: In general, keep away from strong oxidizers, moisture, strong acids, strong bases. This is a thiocyanate compound. Violent reactions may occur upon contact with chlorates (potassium chlorate, sodium chlorate), nitrates, nitric acid; organic peroxides.

Chemical Properties

off-white to yellow to beige-grey crystalline

Uses

Reagent for solid-phase sequencing.

Uses

anthelmintic

Uses

It is used in the treatment of?hookworms.

Definition

ChEBI: Bitoscanate is a member of benzenes.

General Description

Odorless colorless crystals. Melting point 132°C.

Reactivity Profile

1,4-PHENYLENE DIISOTHIOCYANATE reacts readily with amines [Noller]. These reactions may generate significant amounts of heat . Emits very toxic fumes of nitrogen oxides and sulfur oxides when heated to decomposition [EPA, 1998].

Health Hazard

1,4-PHENYLENE DIISOTHIOCYANATE is highly toxic if ingested. It is a central nervous system and gastrointestinal toxin in humans.

Fire Hazard

When heated to decomposition, 1,4-PHENYLENE DIISOTHIOCYANATE emits very toxic fumes of nitrogen oxides and sulfur oxides.

Safety Profile

Poison by ingestion and intraperitoneal routes. Human systemic effects by ingestion: hallucinations, nausea. When heated to decomposition it emits very toxic fumes of NOx,CN,and SOx.See also THIOCYANATES

Potential Exposure

Those engaged in the manufacture, formulation and application of this anthelmintic compound. Incompatibilities: In general, keep away from strong oxidizers, moisture, strong acids, strong bases. This is a thiocyanate compound. Violent reactions may occur upon contact with chlorates (potassium chlorate, sodium chlorate), nitrates, nitric acid; organic peroxides.

First aid

If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seekmedical attention immediately. If this chemical contactsthe skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove fromexposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing hasstopped and CPR if heart action has stopped. Transferpromptly to a medical facility. When this chemical hasbeen swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit. For cyanide poisoning, use amylnitrate capsules if symptoms develop. All area employeesshould be trained regularly in emergency measures for cyanide poisoning and in CPR. A cyanide antidote kit shouldbe kept in the immediate work area and must be rapidlyavailable. Kit ingredients should be replaced every 1 2years to ensure freshness. Persons trained in the use of thiskit, oxygen use, and CPR must be quickly available.

storage

Color Code—Green: General storage may be used.Store in tightly closed containers in a cool, well-ventilatedarea. Store under inert gas; moisture sensitive.

Shipping

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1—Poisonous materials, Technical Name Required.

Purification Methods

Purify bitoscanate by recrystallisation from AcOH, pet ether (b 40-60o), Me2CO or aqueous Me2CO. [van der Kerk et al. Recl Trav Chim Pays-Bas 74 1262 1955, Leiber & Slutkin J Org Chem 27 2214 1962, Beilstein 13 IV 174.]

Incompatibilities

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.

1,4-PHENYLENE DIISOTHIOCYANATE Preparation Products And Raw materials

Raw materials

Preparation Products

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1,4-PHENYLENE DIISOTHIOCYANATE Suppliers

Beijing Taiya Jie Technology Development Co., Ltd.
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021-67582001/03/05
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TargetMol Chemicals Inc.
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NINGBO INNO PHARMCHEM CO.,LTD.
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View Lastest Price from 1,4-PHENYLENE DIISOTHIOCYANATE manufacturers

Career Henan Chemical Co
Product
1,4-PHENYLENE DIISOTHIOCYANATE 4044-65-9
Price
US $1.00-1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1lg; 2kg; 5kg; 10kg; 100kg
Release date
2019-08-31

4044-65-9, 1,4-PHENYLENE DIISOTHIOCYANATERelated Search:


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  • 1,4-phenylenedi-isothiocyanicaci
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  • 1,4-Phenylene diisothiocyate, 98%
  • 4-Diisothiocyanatobenzene
  • 16842(uspddn)[qr]
  • ai3-28258[qr]
  • Benzene, 1,4-diisothiocyanato-
  • benzene,1,4-diisothiocyanato-[qr]
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  • bitoscanato[qr]
  • bitoscanatum(latin)[qr]
  • Isothiocyanic acid, 1,4-phenylenedi-
  • Isothiocyanic acid, p-phenylene ester
  • isothiocyanicacid,p-phenyleneester[qr]
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  • WM 842
  • wm842[qr]
  • P-PHENYLENE DIISOTHIOCYANATE
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  • BENZENE 1,4-DIISOTHIOCYANATE
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  • 16842
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  • p-Phenylene diisothiocyanate ,98.5%
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  • JACS-4044-65-9
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