2-FLUORO-5-FORMYLBENZONITRILE

Product Name: 2-FLUORO-5-FORMYLBENZONITRILE
CAS No.: 218301-22-5
Chemical Name: 2-FLUORO-5-FORMYLBENZONITRILE
Synonyms: 3-CYANO-4-FLUOROBENZALDEHYDE;2-Fluor-5-formylbenzonitrile;FFBN;uoro-5-formyL;CYANOFLUOROBENZALDEHYDE-3-4;4-Fluoro-3-cyanobenzaldehyde;3-cyano-4-flluorobenzaldehyd;2-FLUORO-5-FORMYLBENZONITRILE;3-cyano-4-flluorobenzaldehyde;2-Fluoro-S-formylbenzonitrile
CBNumber: CB5293829
Molecular Formula: C8H4FNO
Formula Weight: 149.12
MOL File: 218301-22-5.mol

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2-FLUORO-5-FORMYLBENZONITRILE Property

Melting point:: 80-84 °C (lit.)
Boiling point:: 215.6±20.0 °C(Predicted)
Density: 1.25±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Chloroform, Methanol
form: Solid
color: White
InChI: InChI=1S/C8H4FNO/c9-8-2-1-6(5-11)3-7(8)4-10/h1-3,5H
InChIKey: MOFRJTLODZILCR-UHFFFAOYSA-N
SMILES: C(#N)C1=CC(C=O)=CC=C1F
CAS DataBase Reference: 218301-22-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22-36/37/38
Safety Statements: 26-36
WGK Germany: 3
Hazard Note: Harmful
HazardClass: IRRITANT
HS Code: 29269090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 494089
Product name: 2-Fluoro-5-formylbenzonitrile
Purity: 97%
Packaging: 5g
Price: $351
Updated: 2023/06/20

TCI Chemical

Product number: C2692
Product name: 3-Cyano-4-fluorobenzaldehyde
Purity: >98.0%(GC)
Packaging: 1g
Price: $32
Updated: 2025/07/31

TCI Chemical

Product number: C2692
Product name: 3-Cyano-4-fluorobenzaldehyde
Purity: >98.0%(GC)
Packaging: 5g
Price: $94
Updated: 2025/07/31

TRC

Product number: C987515
Product name: 3-Cyano-4-fluorobenzaldehyde
Packaging: 10g
Price: $950
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0021769
Product name: 3-CYANO-4-FLUOROBENZALDEHYDE
Purity: 95.00%
Packaging: 1G
Price: $716.1
Updated: 2021/12/16

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2-FLUORO-5-FORMYLBENZONITRILE Chemical Properties,Usage,Production

Description

2-Fluoro-5-formylbenzonitrile is a pharmaceutical intermediate compound used in the preparation of Olaparib, a PARP inhibitor for the treatment of a variety of cancers including advanced ovarian, fallopian tube, or primary peritoneal cancers with a certain hereditary (germline) or acquired (somatic) abnormality of the BRCA gene.

Chemical Properties

White Solid

Uses

2-Fluoro-5-formylbenzonitrile may be used in the synthesis of 3-cyano-4-fluorobenzyl bromide. It could be used to synthesis 2-fluoro-5-(4-ethoxybenzyl)benzonitrile. 2-Fluoro-5-formylbenzonitrile (10g, 1eq) was dissolved in 100mL 1,4-dioxane, p-toluenesulfonyl hydrazide (13.7g, 1eq) was added, stirred at room temperature for 3 hours, and then added Potassium carbonate (13.9 g, 1.5 eq), 4-ethoxyphenylboronic acid (12.2 g, 1 eq), warmed to 100 C. and stirred for 12 hours. After TLC monitoring the reaction of the raw materials, filter, spin dry the filtrate, add petroleum ether and stir for half an hour, filter, and spin dry the filtrate to obtain 15 g of 2-fluoro-5-(4-ethoxybenzyl)benzonitrile (the yield is 88%).

Uses

2-Fluoro-5-ForMyl-benzonitrile is used in the preparation of heterocyclic compounds as PARP inhibitors for medical use.

General Description

2-Fluoro-5-formylbenzonitrile is a benzonitrile derivative.

2-FLUORO-5-FORMYLBENZONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-FLUORO-5-FORMYLBENZONITRILE Suppliers

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View Lastest Price from 2-FLUORO-5-FORMYLBENZONITRILE manufacturers

Jinan Ruitong Biotech Co., Ltd.

Product: 2-Fluoro-5-formylbenzonitrile 218301-22-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1
Release date: 2025-08-28

Shaanxi Dideu New Materials Co. Ltd

Product: 2-FLUORO-5-FORMYLBENZONITRILE 218301-22-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 10000KGS
Release date: 2025-06-06

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2-Fluoro-5-formylbenzonitrile 218301-22-5
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000
Release date: 2025-03-05

218301-22-5, 2-FLUORO-5-FORMYLBENZONITRILERelated Search:

3,4-Difluorobenzonitrile 2,6-Difluorobenzonitrile 2,4-Difluorobenzonitrile o-Phthalaldehyde Olaparib 4-Fluorocinnamaldehyde 3-Cyanobenzaldehyde 4-Fluorobenzaldehyde 4-CHLORO-3-FORMYL-BENZONITRILE 3-FLUORO-5-FORMYLBENZONITRILE 6-(DIMETHYLAMINO)-2-FLUORO-3-FORMYLBENZONITRILE,6-(Dimethylamino)-2-fluoro-3-formylbenzonitrile, 95+%

10014 2-FLUORO-5-FORMYL BENZONITRILE

6002 2-FLUORO-5-FORMYL BENZONITRILE

4-Fluoro-3-cyanobenzaldehyde

2-Fluor-5-formylbenzonitrile

2-Fluoro-5-formylbenzonitrile 97%

3-cyano-4-flluorobenzaldehyde

Benzonitrile, 2-fluoro-5-formyl-

CYANOFLUOROBENZALDEHYDE-3-4

3-CYANO-4-FLUOROBENZALDEHYDE

2-FLUORO-5-FORMYLBENZONITRILE

2-Fluoro-5-Formylbenzonitrile/2-Fluoro-5-Cyanobenzaldehyde

Benzonitrile, 2-fluoro-5-formyl- (9CI)

3-Cyano-4-fluorobenzaldehyde 97%

3-Cyano-4-fluorobenzaldehyde97%

3-Cyano-4-fluorobenzaldehyde&gt

uoro-5-formyL

FFBN

2-Fluoro-5-formylbenzonitrile?New

2-Fluoro-S-formylbenzonitrile

2-Fluor-5-formylbenzonitriChemicalbookle

3-cyano-4-flluorobenzaldehyd

218301-22-5

C8H4NOF

FC6H3CHOCN

Phenyls & Phenyl-Het

Benzaldehyde

Phenyls & Phenyl-Het

C8 to C9

Cyanides/Nitriles

Nitrogen Compounds

HALIDE

ALDEHYDE

Aromatic Nitriles

Aldehydes

john's