Ethoxyquin
- Product Name
- Ethoxyquin
- CAS No.
- 91-53-2
- Chemical Name
- Ethoxyquin
- Synonyms
- eq;Ethoxiquin;emq;Santoflex;ethoxyquine;ETMDQ;niflex;amea100;niflexd;antageaw
- CBNumber
- CB5296077
- Molecular Formula
- C14H19NO
- Formula Weight
- 217.31
- MOL File
- 91-53-2.mol
Ethoxyquin Property
- Melting point:
- <0°C
- Boiling point:
- 123-125°C
- Density
- 1.03 g/mL at 20 °C (lit.)
- vapor pressure
- 0.035Pa at 25℃
- refractive index
- 1.569~1.571
- Flash point:
- 137 °C
- storage temp.
- 2-8°C
- solubility
- ethanol: 50 mL/L, clear, brown
- form
- Liquid
- pka
- 5.02±0.70(Predicted)
- color
- Yellow to Very Dark Brown
- Water Solubility
- <0.1 g/100 mL at 20 ºC
- Merck
- 14,3753
- BRN
- 158223
- Stability:
- Stable. Combustible. Incompatible with oxidizing agents, strong acids. Polymerizes if heated. May polymerize upon exposure to light and air.
- InChIKey
- DECIPOUIJURFOJ-UHFFFAOYSA-N
- LogP
- 3.39
- CAS DataBase Reference
- 91-53-2(CAS DataBase Reference)
- NIST Chemistry Reference
- Quinoline, 6-ethoxy-1,2-dihydro-2,2,4-trimethyl-(91-53-2)
- EPA Substance Registry System
- Ethoxyquin (91-53-2)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22
- Safety Statements
- 24
- RIDADR
- 3082
- WGK Germany
- 1
- RTECS
- VB8225000
- F
- 2-8-10
- HazardClass
- 9
- PackingGroup
- III
- HS Code
- 29334900
- Hazardous Substances Data
- 91-53-2(Hazardous Substances Data)
- Toxicity
- LD50 orally in rats, mice: 1920, 1730 mg/kg (Piul'skaya)
N-Bromosuccinimide Price
- Product number
- E8260
- Product name
- Ethoxyquin
- Purity
- ≥75% (capillary GC)
- Packaging
- 100g
- Price
- $85.78
- Updated
- 2025/07/31
- Product number
- PHR3513
- Product name
- Ethoxyquin
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging
- 500 mg
- Price
- $312
- Updated
- 2025/07/31
- Product number
- 31519
- Product name
- Ethoxyquin
- Purity
- PESTANAL , analytical standard
- Packaging
- 250mg
- Price
- $27.9
- Updated
- 2025/07/31
- Product number
- E0237
- Product name
- 6-Ethoxy-2,2,4-trimethyl-1,2-dihydroquinoline [Antioxidant for rubber]
- Purity
- >90.0%(GC)
- Packaging
- 25g
- Price
- $45
- Updated
- 2025/07/31
- Product number
- E0237
- Product name
- 6-Ethoxy-2,2,4-trimethyl-1,2-dihydroquinoline [Antioxidant for rubber]
- Purity
- >90.0%(GC)
- Packaging
- 500g
- Price
- $179
- Updated
- 2025/07/31
Ethoxyquin Chemical Properties,Usage,Production
Description
Ethoxyquin is used as an antioxidant in animal feed and caused contact dermatitis in a worker at an animal feed mill.
Chemical Properties
Transparent yellow or brown viscous liquid. Discolors and stains badly. Soluble in benzene, gasoline, ether, ethanol, carbon tetrachloride, acetone, dichloroethane, insoluble in water.
Uses
Ethoxyquin is an antioxidant used in the preservation of color in chili powder, ground chili, and paprika.
Uses
Antioxidant in feed and food; antidegradation agent for rubber.
Definition
ChEBI: Ethoxyquin is a quinoline that is 1,2-dihydroquinoline bearing three methyl substituents at position 2, 2 and 4 as well as an ethoxy substituent at position 6. It has a role as a herbicide, an UDP-glucuronosyltransferase activator, a neuroprotective agent, a Hsp90 inhibitor, a genotoxin, a food antioxidant, a geroprotector and an antifungal agrochemical. It is a member of quinolines and an aromatic ether.
General Description
Clear light yellow to dark brown viscous liquid. Discolors and stains badly. Mercaptan-like odor.
Air & Water Reactions
Polymerizes and darkens in color on exposure to light and air. Insoluble in water.
Reactivity Profile
Ethoxyquin may undergo a hazardous polymerization at temperatures above 320° F. Tends to polymerize and darken in color on exposure to light and air. Not compatible with oxidizing agents and with strong acids .
Hazard
Toxic by ingestion.
Fire Hazard
Ethoxyquin is combustible.
Agricultural Uses
Insecticide, Fungicide, Plant growth regulator, Ingredient in other products: Used for preharvest or postharvest preservation of color in apples and pears. It is used as an antioxidant to preserve color in paprika and ground and powdered chili. Ethoxyquin is also a chemical preservative used in animal feed to prevent ingredients from reacting with oxygen and becoming rancid. It has been known to cause birth defects in pet birds and dogs. Not approved for use in EU countries[ 115]. Registered for use in the U.S.
Trade name
CHEMLEY®[C]; DECCOQUIN 305®; EMQ®; EQ®; NIFLEX®; NIX-SCALD®[C]; SANTOFLEX A®; SANTOFLEX AW®; SANTOQUIN®; SANTOQUINE®; STOP-SCALD®
Contact allergens
Ethoxyquin is used as an antioxidant in animal feed and caused contact dermatitis in a worker at an animal feed mill
Safety Profile
Poison by intraperitoneal route. Moderately toxic by ingestion. Mutation data reported. Combustible when exposed to heat or flame; can react with oxidizing materials. When heated to decomposition it emits toxic fumes of NOx.
Synthesis
156-43-4
67-64-1
91-53-2
The general procedure for the synthesis of ethoxyquinoline from p-ethoxyaniline and acetone was as follows: 100 kg of p-aminoanisole, 30 kg of the solvent acetic anhydride and 5 kg of the catalyst cuprous chloride were added to the reaction tank and mixed thoroughly. Subsequently, the reaction mixture was heated to 130°C, and the titration rate of acetone was controlled by a rotameter at atmospheric pressure, and a total of 210 kg of acetone was titrated. The reaction lasted for 12 hours, during which the content of ethoxyquinoline in the reaction mixture was determined periodically. When the content of ethoxyquinoline reached 90% or higher, the reaction mixture was cooled to 75°C. Water and unreacted acetone produced during the reaction were recovered by condensation and the acetone was recycled.
Potential Exposure
Quinoline insecticide, fungicide and plant growth regulator. Also and ingredient in other products. Used for preharvest or postharvest preservation of color in apples and pears. It is used as an anti-oxidant to preserve color in paprika and ground and powdered chili. Ethoxyquin also is a chemical preservative used in animal feed to prevent ingredients from reacting with oxygen and becoming rancid. It has been known to cause birth defects in pet birds and dogs
Shipping
UN3082 Environmentally hazardous substances, liquid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required
Purification Methods
Purify Ethoxyquin by fractional distillation in vacuo whereby the distillate solidifies to a glass. [Knoevenagel Chem Ber 54 1723, 1730 1921.] The methiodide has m 179o (from EtOH), and the 1-phenylcarbamoyl derivative has m 146-147o (from EtOH). [Beaver et al. J Am Chem Soc 79 1236 1957, Beilstein 21 III/IV 95.]
Incompatibilities
Polymerization can occur on contact with strong light and/or water. Decomposes in temperatures above 150℃. Keep away from oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); strong acids.
Waste Disposal
Do not discharge into drains or sewers. Dispose of waste material as hazardous waste using a licensed disposal contractor to an approved landfill. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. If allowed, Incineration with effluent gas scrubbing is recommended. Containers must be disposed of properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office
References
[1] Heteroatom Chemistry, 2012, vol. 23, # 6, p. 598 - 604
[2] Chemische Berichte, 1921, vol. 54, p. 1723,1730
[3] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 21, p. 5081 - 5085
[4] Patent: CN104961679, 2016, B. Location in patent: Paragraph 0023; 0044-0053
[5] European Journal of Pharmaceutical Sciences, 2018, vol. 118, p. 67 - 79
Ethoxyquin Preparation Products And Raw materials
Raw materials
Preparation Products
Ethoxyquin Suppliers
- Tel
- 0371-0371-55629727 13323845623
- Fax
- 037155629727
- 2885676761@qq.com
- Country
- China
- ProdList
- 10110
- Advantage
- 58
- Tel
- 19930503252
- mia@crovellbio.com
- Country
- China
- ProdList
- 1458
- Advantage
- 58
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 4006356688 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- 021-67121386
- Fax
- 021-67121385
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 24529
- Advantage
- 81
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- chenyj@titansci.com
- Country
- China
- ProdList
- 14101
- Advantage
- 59
- Tel
- 025-83697070
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 16075
- Advantage
- 64
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32321
- Advantage
- 50
- Tel
- 15527621225
- 1791901229@qq.com
- Country
- China
- ProdList
- 6950
- Advantage
- 52
- Tel
- 400-1166-196 18981987031
- Fax
- 028-84555506 800101999
- cdhxsj@163.com
- Country
- China
- ProdList
- 11705
- Advantage
- 57
- Tel
- 0086-21-58956006
- Fax
- 0086-21-58956100
- Country
- China
- ProdList
- 7811
- Advantage
- 57
- Tel
- 400 638 7771
- sales@heowns.com
- Country
- China
- ProdList
- 14435
- Advantage
- 57
- Tel
- +86 (573) 82222445 (0)18006601000 452520369
- Fax
- +86 (573) 82222643
- sales@maya-r.com
- Country
- China
- ProdList
- 11707
- Advantage
- 57
- Tel
- 021-021-021-67601398-809-809-809 15221380277
- Fax
- 021-57711696
- marketing_china@spectrumchemical.com
- Country
- China
- ProdList
- 9658
- Advantage
- 60
- Tel
- 021-61312847 13636370518
- Fax
- 021-55068248
- shyysw007@163.com
- Country
- China
- ProdList
- 4999
- Advantage
- 60
- Tel
- 86-21-34053660
- Fax
- 86-21-34053661
- sale@labgogo.com
- Country
- China
- ProdList
- 9865
- Advantage
- 52
- Tel
- 010-56205725
- Fax
- 010-65763397
- waley188@sohu.com
- Country
- China
- ProdList
- 12335
- Advantage
- 58
- Tel
- +86 21 61551611
- Fax
- +86 21 50676805
- Country
- China
- ProdList
- 9891
- Advantage
- 58
- Tel
- 4009209199
- Fax
- 86-021-52271987
- sales@9dingchem.com
- Country
- China
- ProdList
- 22514
- Advantage
- 55
- Tel
- 86 592 2680277
- Fax
- 0086 592 2680237
- sale@simagchem.com
- Country
- China
- ProdList
- 430
- Advantage
- 55
- Tel
- 400-6206333 13167063860
- Fax
- 021-50323701
- anhua.mao@aladdin-e.com
- Country
- China
- ProdList
- 25003
- Advantage
- 65
- Tel
- 021-61552785
- Fax
- 021-55660885
- sales@shshiji.com
- Country
- China
- ProdList
- 9546
- Advantage
- 55
- Tel
- 021-021-33632979 15002134094
- Fax
- 021-33632979
- marketing@targetmol.com
- Country
- China
- ProdList
- 7782
- Advantage
- 58
- Tel
- 0570-3066667
- Fax
- 0570-3063388
- Country
- China
- ProdList
- 3930
- Advantage
- 58
- Tel
- +86-398-3831668
- Fax
- +86-398-3836898
- sales@echempioneer.com
- Country
- China
- ProdList
- 40
- Advantage
- 55
- Tel
- +86 532 68629711 137 8060 5697
- Fax
- +86 532 68629713
- info@aurorachem.com
- Country
- China
- ProdList
- 87
- Advantage
- 58
- Tel
- 0554-2106669
- Fax
- 0554-2666215
- sales1@kedichem.com
- Country
- China
- ProdList
- 4924
- Advantage
- 55
- Tel
- 86-21-51086038
- Fax
- 86-21-51861608
- Country
- China
- ProdList
- 2930
- Advantage
- 58
- Tel
- 0755-0755-66853366 13670046396
- Fax
- 0755-28363542
- sales@chem-strong.com
- Country
- China
- ProdList
- 18333
- Advantage
- 56
- Tel
- 400-1166-196 13458535857
- Fax
- QQ：800101999
- cdhxsj@163.com
- Country
- China
- ProdList
- 13350
- Advantage
- 58
- Tel
- 0512-87182056 18013166090
- Fax
- 0512-87182056
- lingling.qi@yacoo.com.cn
- Country
- China
- ProdList
- 6295
- Advantage
- 60
- Tel
- 15221275939
- Fax
- 021-50706099
- shenlinxing@macklin.cn
- Country
- China
- ProdList
- 15873
- Advantage
- 55
- Tel
- 0571-87396432
- Fax
- 0571-87396431
- sales@jhechem.com
- Country
- China
- ProdList
- 14912
- Advantage
- 59
- Tel
- 010-1234567 18521000990
- Fax
- 86-021-33275113
- sonyuanchemical@163.com
- Country
- China
- ProdList
- 6479
- Advantage
- 50
- Tel
- 025-66028182 18626450290
- yftan@aikonchem.com
- Country
- China
- ProdList
- 16679
- Advantage
- 50
- Tel
- 13391076197
- tombiopharma@163.com
- Country
- China
- ProdList
- 4987
- Advantage
- 55
- Tel
- 027-59599241 18871490274
- Fax
- 027-59599241
- 1400878000@qq.com
- Country
- China
- ProdList
- 9858
- Advantage
- 58
- Tel
- Fax
- -
- xg01_gj@163.com
- Country
- China
- ProdList
- 9484
- Advantage
- 50
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
- Country
- China
- ProdList
- 51395
- Advantage
- 80
- Tel
- 18753684562
- Fax
- 0536-8897109
- 1577399715@qq.COM
- Country
- China
- ProdList
- 1735
- Advantage
- 55
- Tel
- 022-6537-8550 15522853686
- Fax
- 022-2532-9655
- sales@altasci.com.cn
- Country
- China
- ProdList
- 4511
- Advantage
- 55
- Tel
- 4000-819-385 010-62329685 13718666987
- Fax
- 010-62340519
- Country
- China
- ProdList
- 1971
- Advantage
- 55
- Tel
- 18620099427
- Fax
- +86-20-62619665
- amy@howeipharm.com
- Country
- China
- ProdList
- 6687
- Advantage
- 55
- Tel
- 86-21-51086038
- Fax
- 86-21-51861608
- sales@chemwill.com
- Country
- China
- ProdList
- 1974
- Advantage
- 58
- Tel
- 021-52907766-8042
- Fax
- 021-52906523
- Country
- China
- ProdList
- 9941
- Advantage
- 58
- Tel
- 02781293128
- orders@biochemsafebuy.com
- Country
- China
- ProdList
- 9923
- Advantage
- 55
- Tel
- 025-83453382-8005
- Fax
- 025-83453382
- sale@parabiochem.com
- Country
- China
- ProdList
- 9595
- Advantage
- 55
- Tel
- 4009903999 13395398332
- Fax
- 0539-6365991
- sales@xiyashiji.com
- Country
- China
- ProdList
- 20794
- Advantage
- 60
View Lastest Price from Ethoxyquin manufacturers
- Product
- Ethoxyquin 91-53-2
- Price
- US $10.70/kg
- Min. Order
- 10kg
- Purity
- 95%
- Supply Ability
- 10000kg
- Release date
- 2025-06-10
- Product
- powder Ethoxyquin 66% 91-53-2
- Price
- US $1.00/PCS
- Min. Order
- 1PCS
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-10-28
- Product
- Ethoxyquin 91-53-2
- Price
- US $6.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2000KG/Month
- Release date
- 2024-08-08