N,N-Dimethylformamide di-tert-butyl acetal
- Product Name
- N,N-Dimethylformamide di-tert-butyl acetal
- CAS No.
- 36805-97-7
- Chemical Name
- N,N-Dimethylformamide di-tert-butyl acetal
- Synonyms
- 1,1-di-tert-butoxy-N,N-dimethylmethanamine;N,N-DIMETHYLFORMAMIDE DI-TERT-BUTYL ACETAL;N,N-Di-tert-butoxytrimethylamine;1,1-DI-TERT-BUTOXYTRIMETHYLAMINE;Di-tert-butoxyMethyl-diMethyl-aMine;Di-tert-butoxy(dimethylamino)methane;[bis(tert-butoxy)methyl]dimethylamine;N,N-Dimethyldi-tert-butoxymethanamine;N,N-DIMETHYLFORMAMIDE DI-T-BUTYL ACETAL;N,N-Dimethyldi(tert-butyloxy)methanamine
- CBNumber
- CB5296219
- Molecular Formula
- C11H25NO2
- Formula Weight
- 203.32
- MOL File
- 36805-97-7.mol
N,N-Dimethylformamide di-tert-butyl acetal Property
- Boiling point:
- 56-57 °C8 mm Hg(lit.)
- Density
- 0.848 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.413(lit.)
- Flash point:
- 93 °F
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Miscible with toluene and benzene.
- form
- clear liquid
- pka
- 5.34±0.50(Predicted)
- color
- Colorless to Almost colorless
- Specific Gravity
- 0.848
- Sensitive
- Moisture Sensitive
- BRN
- 969629
- InChI
- InChI=1S/C11H25NO2/c1-10(2,3)13-9(12(7)8)14-11(4,5)6/h9H,1-8H3
- InChIKey
- DBNQIOANXZVWIP-UHFFFAOYSA-N
- SMILES
- C(OC(C)(C)C)(OC(C)(C)C)N(C)C
- CAS DataBase Reference
- 36805-97-7(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 10-36/37/38
- Safety Statements
- 26-36
- RIDADR
- UN 1993 3/PG 3
- WGK Germany
- 3
- F
- 10-21
- HazardClass
- 3
- PackingGroup
- III
- HS Code
- 29221990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H226Flammable liquid and vapour
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 40263
- Product name
- N,N-Dimethylformamide di-tert-butyl acetal
- Purity
- technical, ≥90% (GC)
- Packaging
- 10ml
- Price
- $406
- Updated
- 2024/03/01
- Product number
- 40263
- Product name
- N,N-Dimethylformamide di-tert-butyl acetal
- Purity
- technical, ≥90% (GC)
- Packaging
- 50mL
- Price
- $876
- Updated
- 2024/03/01
- Product number
- 395005
- Product name
- N,N-Dimethylformamide di-tert-butyl acetal
- Purity
- for GC derivatization
- Packaging
- 5ml
- Price
- $91.7
- Updated
- 2022/05/15
- Product number
- 395005
- Product name
- N,N-Dimethylformamide di-tert-butyl acetal
- Purity
- for GC derivatization
- Packaging
- 10x1ml
- Price
- $207
- Updated
- 2022/05/15
- Product number
- D1303
- Product name
- N,N-Dimethylformamide Di-tert-butyl Acetal [for Esterification]
- Purity
- >98.0%(N)
- Packaging
- 5mL
- Price
- $115
- Updated
- 2024/03/01
N,N-Dimethylformamide di-tert-butyl acetal Chemical Properties,Usage,Production
Uses
Reagent used for the preparation of indolizines via intermolecular cyclization of picolinium salts.
Uses
N,N-Dimethylformamide di-tert-butyl acetal may be used in the synthesis of following:
- (S)-2-(1-tert-butoxycarbonyl-2-{4-[2-(5-methyl-2-phenyloxazol-4-yl)ethoxy]phenyl}ethylamino)benzoic acid methyl ester
- 3-O-tert-butylmorphine
- tert-butylesters of pyrrole- and indolecarboxylic acids
Synthesis Reference(s)
Synthetic Communications, 15, p. 723, 1985 DOI: 10.1080/00397918508063864
General Description
N,N-Dimethylformamide di-tert-butyl acetal is an derivatizing reagent.
Synthesis
A mixture of 59.5 g (0.5 mol) of N, N-dimethylformamide dimethyl acetal and 147 mL (1.5 mol) of dry tert-butanol in a three-necked flask (250 mL) fitted with a thermometer magnetic stirrer, nitrogen inlet and a 33 x 1.9 cm silvered vacuum jacketed Goodloe column which was equipped with a reflux controlled take-off distilling head was heated at reflux for 1 hr, then 300 mg of 2,4,6-tri-tert-butylphenol was added. The reaction mixture was heated at 100-115°C for 48 hrs, during which time, at the rate of two drops/min, 56 mL of distillate was collected. Another 50 mL (0.52 mol) of tert-butanol was added to the reaction mixture, and the removal of methanol was continued for an additional 42 hrs to afford 64 mL of distillate. Distillation of the crude product with a similar but smaller column (20 x 1.4 cm) gave 53.2 g (52%) of N, N-Dimethylformamide di-tert-butyl acetal[1].
References
[1] Mohacsi, E. “A New Synthetic Method for the Preparation of N,N-Dimethylformamide DI-Tert-Butyl Acetal.” Synthetic Communications 15 1 (1985): 723–725.
N,N-Dimethylformamide di-tert-butyl acetal Preparation Products And Raw materials
Raw materials
Preparation Products
N,N-Dimethylformamide di-tert-butyl acetal Suppliers
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View Lastest Price from N,N-Dimethylformamide di-tert-butyl acetal manufacturers
- Product
- N,N-DIMETHYLFORMAMIDE DI-TERT-BUTYL ACETAL 36805-97-7
- Price
- US $1.00-1.00/kg
- Min. Order
- 1kg
- Purity
- 90%
- Supply Ability
- 10 tons
- Release date
- 2024-08-13
- Product
- 1,1-Di-tert-butoxytrimethylamine 36805-97-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-05