PLX7904

Product Name: PLX7904
CAS No.: 1393465-84-3
Chemical Name: PLX7904
Synonyms: 5-(2-cyclopropylpyrimidin-5-yl)-3-[3-[[ethyl(methyl)sulfamoyl]amino]-2,6-difluorobenzoyl]-1H-pyrrolo[2,3-b]pyridine;PB04;PB-04;PB 04;PLX7904;PLX 7907;PLX7904(PB04);paradox-breaker-04;PLX-7904;PLX 7907;PB04; PB-04; PB 04; PARADOX-BREAKER-04;N'-[3-[[5-(2-Cyclopropyl-5-pyrimidinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-N-ethyl-N-methylsulfamide
CBNumber: CB53053925
Molecular Formula: C24H22F2N6O3S
Formula Weight: 512.53
MOL File: 1393465-84-3.mol

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PLX7904 Property

storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: A crystalline solid
color: White to light brown

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 20710
Product name: PLX7904
Purity: ≥98%
Packaging: 1mg
Price: $38
Updated: 2024/03/01

Cayman Chemical

Product number: 20710
Product name: PLX7904
Purity: ≥98%
Packaging: 5mg
Price: $166
Updated: 2024/03/01

Cayman Chemical

Product number: 20710
Product name: PLX7904
Purity: ≥98%
Packaging: 10mg
Price: $275
Updated: 2024/03/01

Cayman Chemical

Product number: 20710
Product name: PLX7904
Purity: ≥98%
Packaging: 25mg
Price: $581
Updated: 2023/06/20

ChemScene

Product number: CS-5129
Product name: PLX7904
Purity: 98.80%
Packaging: 5mg
Price: $60
Updated: 2021/12/16

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PLX7904 Chemical Properties,Usage,Production

Biological Activity

plx7904 is a potent and selective braf inhibitor.oncogenic activation of braf leads to cancer growth by constitutively promoting ras-independent mitogen-activated protein kinase pathway signalling. therefore, braf inhibitors have provided substantially improved treatment of metastatic melanoma.

in vitro

previous study showed that plx7904 could inhibit the in-vitro growth of two melanoma cell lines (a375 and colo829) and an additional human colorectal cancer cell line colo205 expressed brafv600e. the gene expression changes in b9 cells treated with vemurafenib and plx7904 were compared, and results demonstrated that vemurafenib could alter transcription of 191 mouse genes by at least 1.9-fold, while plx7904 had minimal effects. moreover, both vemurafenib and its analogue plx4720 werer able to stimulate b9 colony formation, whereas plx7904 was not [1].

in vivo

animal study showed that both plx7904 and vemurafenib could produce similar anti-tumour effects in a subcutaneous colo205 xenograft model with matching doses at 25 mg/kg twice daily and plasma exposures. in addition, when evaluated in vivo, subcutaneous b9-tumour growth was accelerated by vemurafenib but not by plx7904 when administered at the same dose [1].

IC 50

0.17, 0.53, and 0.16 μm for a375, colo829 and colo205 cell lines, respectively.

References

[1] zhang c et al. raf inhibitors that evade paradoxical mapk pathway activation. nature.2015 oct 22;526(7574):583-6.

PLX7904 Preparation Products And Raw materials

Raw materials

Preparation Products

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PLX7904 Suppliers

China 92 United States 8 Global 100

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32165
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

TargetMol Chemicals Inc.

Tel
Email: support@targetmol.com
Country: United States
ProdList: 38632
Advantage: 58

ApexBio Technology

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Email: sales@apexbt.com
Country: United States
ProdList: 6251
Advantage: 58

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

Cayman Chemical Company

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Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

1393465-84-3, PLX7904Related Search:

PLX647 PLX-4720 PLX8394

PLX7904

5-(2-cyclopropylpyrimidin-5-yl)-3-[3-[[ethyl(methyl)sulfamoyl]amino]-2,6-difluorobenzoyl]-1H-pyrrolo[2,3-b]pyridine

PLX7904(PB04)

paradox-breaker-04

PB 04

PB04

PB-04

PLX 7907

PLX-7904;PLX 7907;PB04; PB-04; PB 04; PARADOX-BREAKER-04

Sulfamide, N'-[3-[[5-(2-cyclopropyl-5-pyrimidinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-N-ethyl-N-methyl-

N'-[3-[[5-(2-Cyclopropyl-5-pyrimidinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-N-ethyl-N-methylsulfamide

1393465-84-3

C24H22F2N6O3S