ST072042

Product Name: ST072042
CAS No.: 88349-90-0
Chemical Name: ST072042
Synonyms: A2793;ST072042;ethyl 2-(5-chloroquinolin-8-yl)oxyacetate;ethyl [(5-chloroquinolin-8-yl)oxy]acetate;ethyl 2-[(5-chloro-8-quinolyl)oxy]acetate;ethyl 2-(5-chloroquinolin-8-yl)oxyethanoate;2-[(5-chloro-8-quinolyl)oxy]acetic acid ethyl ester;Acetic acid, 2-[(5-chloro-8-quinolinyl)oxy]-, ethyl ester;A2793,inhibit,Inhibitor,A-2793,TALK-1,TRESK,pain,KcsA,TASK-1,A 2793,Potassium Channel
CBNumber: CB53056845
Molecular Formula: C13H12ClNO3
Formula Weight: 265.69
MOL File: 88349-90-0.mol

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ST072042 Property

Boiling point:: 393.4±27.0 °C(Predicted)
Density: 1.291±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 100 mg/mL (376.38 mM)
pka: 1.97±0.29(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0140439
Product name: A2793
Purity: 99.81%
Packaging: 5mg
Price: $150
Updated: 2021/12/16

Matrix Scientific

Product number: 156285
Product name: Ethyl [(5-chloroquinolin-8-yl)oxy]acetate
Packaging: 0.500g
Price: $160
Updated: 2021/12/16

Matrix Scientific

Product number: 156285
Product name: Ethyl [(5-chloroquinolin-8-yl)oxy]acetate
Packaging: 1g
Price: $200
Updated: 2021/12/16

AK Scientific

Product number: 8921CZ
Product name: Ethyl[(5-chloroquinolin-8-yl)oxy]acetate
Packaging: 250mg
Price: $248
Updated: 2021/12/16

ChemScene

Product number: CS-0140439
Product name: A2793
Purity: 99.81%
Packaging: 10mg
Price: $250
Updated: 2021/12/16

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ST072042 Chemical Properties,Usage,Production

Biological Activity

A2793 (Ethyl [(5-Chloroquinolin-8-yl)oxy]acetate) is a TWIK-related spinal cord potassium channel (TRESK, K2P18, KCNK18) and TASK-1 (KCNK3) with IC50 of 6.8 μM for mouse TRESK .

in vitro

A2793 (100 μM) inhibits the unstimulated channel by 43.0±8.9% (n=5) while after ionomycin activation the reduction of the TRESK current is 85.5±2.9% (n=5).
It inhibits TASK-1 (100 μM, 53.4±13,5%, n=5), while A2764 is more selective for TRESK, it only moderately influences TREK-1 and TALK-1.
A2793 may be considered as a tool to discriminate between the resting and activated channels in heterologous expression systems, and to block TRESK activated by calcineurin in the native cells which do not express TASK-1.

target

Target	Value
mTRESK (Cell-free assay)	6.8 μM

ST072042 Preparation Products And Raw materials

Raw materials

Preparation Products

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ST072042 Suppliers

China 28 United Kingdom 1 United States 7 Global 36

TargetMol Chemicals Inc.

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88349-90-0, ST072042Related Search:

2-[(5-chloro-8-quinolyl)oxy]acetic acid ethyl ester

ethyl [(5-chloroquinolin-8-yl)oxy]acetate

ethyl 2-(5-chloroquinolin-8-yl)oxyacetate

ethyl 2-(5-chloroquinolin-8-yl)oxyethanoate

ethyl 2-[(5-chloro-8-quinolyl)oxy]acetate

ST072042

A2793

Acetic acid, 2-[(5-chloro-8-quinolinyl)oxy]-, ethyl ester

A2793,inhibit,Inhibitor,A-2793,TALK-1,TRESK,pain,KcsA,TASK-1,A 2793,Potassium Channel

88349-90-0