ChemicalBook > CAS DataBase List > 4-(3-AMINO-PHENYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

4-(3-AMINO-PHENYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Product Name: 4-(3-AMINO-PHENYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
CAS No.: 387827-19-2
Chemical Name: 4-(3-AMINO-PHENYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
Synonyms: 3-(1-Boc-4-piperidyl)aniline;tert-Butyl 4-(3-aminophenyl);N-BOC-4-(3-AMINOPHENYL) PIPERIDINE;4-(3-aminophenyl)piperidine-1-carboxylate;tert-Butyl 4-(3-aminophenyl)piperidin-1-carboxylate;TERT-BUTYL 4-(3-AMINOPHENYL)PIPERIDINE-1-CARBOXYLATE;Tert-butyl 4-[3-(amino)phenyl]-1-Piperidinecarboxylate;1,1-Dimethylethyl 4-(3-aminophenyl)-1-piperidinecarboxylate;4-(3-AMINO-PHENYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-Piperidinecarboxylic acid, 4-(3-aMinophenyl)-, 1,1-diMethylethyl ester
CBNumber: CB5305810
Molecular Formula: C16H24N2O2
Formula Weight: 276.37
MOL File: 387827-19-2.mol

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4-(3-AMINO-PHENYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Property

Boiling point:: 413.2±45.0 °C(Predicted)
Density: 1.100±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 4.60±0.10(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

SynQuest Laboratories

Product number: 4H56-1-697
Product name: tert-Butyl 4-(3-aminophenyl)piperidine-1-carboxylate
Purity: 97.0%
Packaging: 250mg
Price: $760
Updated: 2021/12/16

Matrix Scientific

Product number: 124381
Product name: 1-Boc-4-(3-aminophenyl)piperidine
Purity: 97.0%
Packaging: 1g
Price: $1716
Updated: 2021/12/16

AK Scientific

Product number: 5022AB
Product name: 1-Boc-4-(3-aminophenyl)piperidine
Packaging: 10g
Price: $2619
Updated: 2021/12/16

AK Scientific

Product number: J55669
Product name: 1-Boc-4-(3-aminophenyl)piperidine
Packaging: 25g
Price: $3841
Updated: 2021/12/16

Synthonix

Product number: A14918
Product name: 1-Boc-4-(3-aminophenyl)piperidine
Purity: 97.0%
Packaging: 25g
Price: $5190
Updated: 2021/12/16

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4-(3-AMINO-PHENYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production

Synthesis

387827-18-1

387827-19-2

Tert-butyl 4-(3-aminophenyl)-5,6-dihydropyridine-1(2H)-carboxylate (3.10 g, 11.3 mmol) was used as a raw material and mixed with 10% Pd/C (1.00 g) in ethanol (100 mL). The reaction system was hydrogenated at room temperature for 2 days using the balloon method. After completion of the reaction, the mixture was filtered through diatomaceous earth and the filter cake was washed with ethanol. The ethanol extracts were combined and concentrated under reduced pressure. The residue was purified by silica gel column chromatography with the eluent dichloromethane:methanol:isopropylamine (95:5:1, v/v/v) to afford the target product tert-butyl 4-(3-aminophenyl)-piperidine-1-carboxylate (2.63 g, 84% yield). The product was characterized by 1H NMR (400 MHz, CDCl3): δ 7.10 (t, 1H, J = 7.6 Hz), 6.62 (d, 1H, J = 8.4 Hz), 6.60-6.59 (m, 2H), 4.27-4.18 (m, 2H), 3.62-3.58 (m, 2H), 2.80-2.72 (m, 2H), and 2.62-2.59 (m, 1H), 1.89-1.52 (m, 4H), 1.49 (s, 9H); ESMS m/e: 277.2 (M + H)+.

References

[1] Patent: US2004/38855, 2004, A1
[2] Patent: WO2004/5257, 2004, A1. Location in patent: Page 54
[3] Patent: US6727264, 2004, B1. Location in patent: Page column 56; 91
[4] Patent: US2005/154020, 2005, A1. Location in patent: Page/Page column 8
[5] Patent: US2005/154022, 2005, A1. Location in patent: Page/Page column 4; 9

4-(3-AMINO-PHENYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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387827-19-2, 4-(3-AMINO-PHENYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTERRelated Search:

tert-butyl 4-(3-cyano-4-(methoxycarbonyl)phenyl)piperazine-1-carboxylate TERT-BUTYL 4-BROMOBENZYLCARBAMATE Pentanoic acid, 4,5-diamino-5-oxo-, 1,1-dimethylethyl ester tert-butyl 4-(2-aminoethyl)-3,3-difluoropiperidine-1-carboxylate 1-N-Boc-4-(Phenylamino)piperidine INDEX NAME NOT YET ASSIGNED tert-butyl 4-(2-bromo-5-fluoropyridin-4-yl)-4-hydroxypiperidine-1-carboxylate 5H-Pyrrolo[3,2-c]pyridine-5-carboxylic acid, 1,4,6,7-tetrahydro-4-oxo-2-(4-pyridinyl)-, 1,1-dimethylethyl ester 1-Piperazinecarboxylic acid, 4-[3-bromo-4-(methoxycarbonyl)phenyl]-, 1,1-dimethylethyl ester 1-Boc-4-(2-hydroxyethyl)piperidine 4-(2-AMINO-PHENYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 4-(3-AMINO-PHENYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

4-(3-AMINO-PHENYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

TERT-BUTYL 4-(3-AMINOPHENYL)PIPERIDINE-1-CARBOXYLATE

N-BOC-4-(3-AMINOPHENYL) PIPERIDINE

1-Piperidinecarboxylic acid, 4-(3-aMinophenyl)-, 1,1-diMethylethyl ester

Tert-butyl 4-[3-(amino)phenyl]-1-Piperidinecarboxylate

tert-Butyl 4-(3-aminophenyl)

3-(1-Boc-4-piperidyl)aniline

1,1-Dimethylethyl 4-(3-aminophenyl)-1-piperidinecarboxylate

4-(3-aminophenyl)piperidine-1-carboxylate

tert-Butyl 4-(3-aminophenyl)piperidin-1-carboxylate

387827-19-2

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