ChemicalBook > CAS DataBase List > 4-(4-FLUORO-PHENYL)-PIPERIDINE

4-(4-FLUORO-PHENYL)-PIPERIDINE

Product Name
4-(4-FLUORO-PHENYL)-PIPERIDINE
CAS No.
37656-48-7
Chemical Name
4-(4-FLUORO-PHENYL)-PIPERIDINE
Synonyms
Albb-005757;4-(4-FLUORO-PHENYL)-PIPERIDINE;Piperidine, 4-(4-fluorophenyl)-;4-(Fluoro-phenyl)-piperidine hydrochloride
CBNumber
CB5306004
Molecular Formula
C11H14FN
Formula Weight
179.23
MOL File
37656-48-7.mol
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4-(4-FLUORO-PHENYL)-PIPERIDINE Property

Boiling point:
258.6±40.0 °C(Predicted)
Density 
1.048±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
10.18±0.10(Predicted)
Appearance
Colorless to light yellow Liquid
InChI
InChI=1S/C11H14FN/c12-11-3-1-9(2-4-11)10-5-7-13-8-6-10/h1-4,10,13H,5-8H2
InChIKey
AFYALJSDFPSAAZ-UHFFFAOYSA-N
SMILES
N1CCC(C2=CC=C(F)C=C2)CC1
CAS DataBase Reference
37656-48-7(CAS DataBase Reference)
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Safety

Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical
Product number
F1333
Product name
4-(4-Fluorophenyl)piperidine
Purity
min. 98.0 %
Packaging
250MG
Price
$120
Updated
2025/07/31
TRC
Product number
B435120
Product name
4-(4-Fluorophenyl)piperidine
Packaging
100mg
Price
$75
Updated
2021/12/16
AK Scientific
Product number
W5851
Product name
4-(4-Fluorophenyl)piperidine
Packaging
250mg
Price
$89
Updated
2021/12/16
Oakwood
Product number
011727
Product name
4-(4-Fluoro-phenyl)-piperidinehydrochloride
Packaging
250mg
Price
$23
Updated
2021/12/16
Oakwood
Product number
011727
Product name
4-(4-Fluoro-phenyl)-piperidinehydrochloride
Packaging
1g
Price
$46
Updated
2021/12/16
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4-(4-FLUORO-PHENYL)-PIPERIDINE Chemical Properties,Usage,Production

Synthesis

163630-89-5

37656-48-7

4-(4-Fluorophenyl)-1,2,3,6-tetrahydro-1-(phenylmethyl)pyridine (60 g, 225 mmol) was used as a raw material and dissolved in methanol (500 mL). To this solution, palladium/carbon hydroxide (20%, 5 g) was added and the reaction was shaken under hydrogen atmosphere (50 psi) for 48 hours. Upon completion of the reaction, the mixture was filtered through a glass fiber mat and washed with methanol. The filtrate was concentrated under reduced pressure to remove the solvent. The residue was dissolved in ethyl acetate and a 1 M solution of ether hydrogen chloride (300 mL) was added. The resulting solid was collected and recrystallized from 2-propanol to give 4-(4-fluorophenyl)piperidine hydrochloride as a colorless solid (30.5 g, 63% yield). Mass spectral data: m/z (ES+) 180 (M+1). The resulting 4-(4-fluorophenyl)piperidine hydrochloride sample (1 g, 4.64 mmol) was suspended in ethyl acetate and washed with saturated aqueous sodium carbonate. The organic layer was dried with anhydrous magnesium sulfate and the solvent was evaporated under reduced pressure to give the title compound 4-(4-fluorophenyl)piperidine as a colorless oil (825 mg, 99% yield). Mass spectral data: m/z (ES+) 180 (M+1).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 4, p. 495 - 500
[2] Patent: US6218390, 2001, B1
[3] European Journal of Medicinal Chemistry, 2005, vol. 40, # 12, p. 1197 - 1205
[4] Patent: US2003/236250, 2003, A1. Location in patent: Page 19

4-(4-FLUORO-PHENYL)-PIPERIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(4-FLUORO-PHENYL)-PIPERIDINE Suppliers

China 73 Germany 1 India 2 Ukraine 1 United Kingdom 4 United States 20 Global 101
Leancare Ltd.
Tel
--
Fax
--
Email
enquiry@leancare.co.uk
Country
United Kingdom
ProdList
6446
Advantage
42
Apollo Scientific Ltd.
Tel
--
Fax
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Email
sales@apolloscientific.co.uk
Country
United Kingdom
ProdList
6084
Advantage
88
Fluorochem Ltd
Tel
--
Fax
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Email
vernam@fluorochem.co.uk
Country
United Kingdom
ProdList
6375
Advantage
65
Fluorochem Ltd.
Tel
--
Fax
--
Email
enquiries@fluorochem.co.uk
Country
United Kingdom
ProdList
6401
Advantage
74
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View Lastest Price from 4-(4-FLUORO-PHENYL)-PIPERIDINE manufacturers

Henan Fengda Chemical Co., Ltd
Product
4-(4-FLUORO-PHENYL)-PIPERIDINE 37656-48-7
Price
US $101.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-28
Career Henan Chemical Co
Product
4-(4-FLUORO-PHENYL)-PIPERIDINE 37656-48-7
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-08

37656-48-7, 4-(4-FLUORO-PHENYL)-PIPERIDINERelated Search:

Paroxetine maleate N-Methylparoxetine 4-(4-Fluorophenyl)-3-hydroxymethyl-1-methyl-piperidine Paroxetine 3-(Benzo[1,3]dioxol-5-yloxymethyl)-4-(4-fluoro-phenyl)-piperidine 4-(4-FLUORO-PHENYL)-PIPERIDINE 4-(4-FLUORO-PHENYL)-PIPERIDINE HYDROCHLORIDE Paroxetine hydrochloride TRANS-4-(4-FLUOROPHENYL)-3-PIPERIDINEME& 4-(4-FLUORO-PHENYL)-PIPERIDIN-4-OL HYDROCHLORIDE (-)-2-BETA-CARBOMETHOXY-3-BETA-(4-FLUOROPHENYL)TROPANE 4-(4-FLUORO-PHENYL)-PIPERIDINE HCL SALT 4-Aminomethyl-4-(4-fluoro-phenyl)-piperidine-1-carboxylic acid tert-butyl ester 4-(3-FLUORO-PHENYL)-PIPERIDINE Flazalone 4-(4-FLUOROPHENYL)-3-METHYL-2,6-DIPHENYLPIPERIDIN-4-OL HYDROCHLORIDE 4-(4-FLUOROPHENYL)-2,6-DIPHENYL-3-PROPYLPIPERIDIN-4-OL (3S,4R,5R)-1-BENZYL-5-CHLORO-4-(4-FLUORO-PHENYL)-PIPERIDINE-3-CARBOXYLIC ACID TERT-BUTYL ESTER

  • 4-(4-FLUORO-PHENYL)-PIPERIDINE
  • 4-(Fluoro-phenyl)-piperidine hydrochloride
  • Albb-005757
  • Piperidine, 4-(4-fluorophenyl)-
  • 37656-48-7
  • C11H14FNHCl
  • C11H15FNCl