ChemicalBook > CAS DataBase List > 2-(Aminomethyl)-1-ethylpyrrolidine

2-(Aminomethyl)-1-ethylpyrrolidine

Product Name
2-(Aminomethyl)-1-ethylpyrrolidine
CAS No.
26116-12-1
Chemical Name
2-(Aminomethyl)-1-ethylpyrrolidine
Synonyms
Sulpiride impurity A CRS;Amisulpride EP Impurity A;1-ethylpyrrolidin-2-ylmethylamine;)-1-ethyL;Refer to S-402;Sulpiride EP Impurity A;Sulpiride Impurity A(EP);1-Ethyl-2-pyrrolidinemethylamine;n-ethyl-2-methylaminopyrrolidine;N-ETHYL-2-AMINOMETHYLPYRROLIDINE
CBNumber
CB5307995
Molecular Formula
C7H16N2
Formula Weight
128.22
MOL File
26116-12-1.mol
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2-(Aminomethyl)-1-ethylpyrrolidine Property

Boiling point:
58-60 °C16 mm Hg(lit.)
Density 
0.884 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.4670(lit.)
Flash point:
135 °F
storage temp. 
2-8°C
solubility 
Chloroform (Sparingly), Methanol (Sparingly)
pka
10.04±0.40(Predicted)
form 
Liquid
color 
Clear yellow
InChI
InChI=1S/C7H16N2/c1-2-9-5-3-4-7(9)6-8/h7H,2-6,8H2,1H3
InChIKey
UNRBEYYLYRXYCG-UHFFFAOYSA-N
SMILES
N1(CC)CCCC1CN
LogP
0.433 (est)
CAS DataBase Reference
26116-12-1(CAS DataBase Reference)
NIST Chemistry Reference
2-Pyrrolidinemethanamine, 1-ethyl-(26116-12-1)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-20/21/22
Safety Statements 
26-36
RIDADR 
UN 1993 3/PG 3
WGK Germany 
3
HazardClass 
3.2
PackingGroup 
III
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H226Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
655600
Product name
2-(Aminomethyl)-1-ethylpyrrolidine
Purity
97%
Packaging
5g
Price
$82.09
Updated
2025/07/31
Sigma-Aldrich
Product number
S2191000
Product name
Sulpiride impurity A
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
20 mg
Price
$225
Updated
2025/07/31
Sigma-Aldrich
Product number
655600
Product name
2-(Aminomethyl)-1-ethylpyrrolidine
Purity
97%
Packaging
25g
Price
$488
Updated
2025/07/31
TCI Chemical
Product number
A2556
Product name
2-(Aminomethyl)-1-ethylpyrrolidine
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$43
Updated
2025/07/31
TCI Chemical
Product number
A2556
Product name
2-(Aminomethyl)-1-ethylpyrrolidine
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$125
Updated
2025/07/31
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2-(Aminomethyl)-1-ethylpyrrolidine Chemical Properties,Usage,Production

Chemical Properties

clear yellow liquid

Uses

2-(Aminomethyl)-1-ethylpyrrolidine is used as a reagent in the synthesis of S-Desethyl S-Methyl Amisulpride (D289595)

Synthesis

2167-14-8

26116-12-1

General procedure for the synthesis of N-ethyl-2-aminomethylpyrrolidine from 1-ethyl-1H-pyrrole-2-carboxaldehyde: 60 g of 1-ethyl-1H-pyrrole-2-carboxaldehyde was added to an autoclave, and 5 g of palladium-carbon catalyst at a mass percent concentration of 5% and 15 g of liquid ammonia were added to carry out hydrogenation and reductive amination reactions. The reaction conditions were hydrogen pressure of 35 kg and temperature of 95°C. After completion of the reaction, the system was cooled, the gas was expelled, and filtration was carried out. The filter cake was washed with methanol, and the filtrate and washings were combined to recover methanol. Finally, the target product N-ethyl-2-aminomethylpyrrole was obtained by purification via decompression distillation in a yield of 53.7 g and 86%. The reaction equation was as follows:

References

[1] Patent: CN107973735, 2018, A. Location in patent: Paragraph 0017; 0027-0029

2-(Aminomethyl)-1-ethylpyrrolidine Preparation Products And Raw materials

Raw materials

N,N-Dimethylformamide Tetrahydrofurfuryl alcohol

Preparation Products

Remoxipride Levosulpiride
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View Lastest Price from 2-(Aminomethyl)-1-ethylpyrrolidine manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
2-(Aminomethyl)-1-ethylpyrrolidine 26116-12-1
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-04-12
Henan Aochuang Chemical Co.,Ltd.
Product
2-(Aminomethyl)-1-ethylpyrrolidine 26116-12-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-10-13
Shaanxi Dideu Medichem Co. Ltd
Product
2-(Aminomethyl)-1-ethylpyrrolidine 26116-12-1
Price
US $1.00-1.00/KG
Min. Order
160KG
Purity
99.0%GC
Supply Ability
2000tons
Release date
2021-03-09

26116-12-1, 2-(Aminomethyl)-1-ethylpyrrolidineRelated Search:

2,5-Dimethylpyrrolidine Hexamethyldisilazane Pyrrolidine Ethyl acrylate Ethylparaben CHLOROETHANE 1-Methylpyrrolidine N-Methyl-2-pyrrolidone Ethyl formate Ethylbenzene Ethyl cellulose Ethyl acetate Ethanol METHYL-2-PYRROLIDONE Actinomycin D N-Acetyl-L-prolinamide (R)-(+)-2-AMINOMETHYL-1-ETHYLPYRROLIDINE Diethyl ether

  • (1-Ethyl-2-pyrrolidinyl)methanamine
  • 1-Ethyl-2-(aminomethyl)pyrrolidine
  • 1-Ethyl-2-pyrrolidinemethylamine
  • 2-(Aminomethyl)-N-ethylpyrrolidine
  • AMisulpride IMpurity A (Sulpiride IMpurity A)
  • Sulpiride IMpurity A (AMisulpride IMpurity A)
  • Pyrrolidine, 2-(aminomethyl)-1-ethyl-
  • 2-(Aminomethyl)-1-ethylpyrrolidine 97%
  • Sulpiride Impurity A(EP)
  • [(2RS)-1-ethylpyrrolidin-2- yl]methanamine
  • Sulpiride Impurity 1（Sulpiride EP Impurity A）
  • N-Ethyl-2-Aminomethyl Pirrolidine
  • Sulpiride EP Impurity A
  • Amisulpride Impurity 1（Amisulpride EP Impurity A)
  • Amisulpride EP Impurity A
  • 2-(AMINOMETHYL)-1-ETHYLPYRROLIDINE
  • 2-PYRROLIDINEMETHANAMINE, 1-ETHYL-, (2S)-
  • n-ethyl-2-methylaminopyrrolidine
  • N-ETHYL-2-AMINOMETHYLPYRROLIDINE
  • N-ETHYL-ALPHA-AMINOMETHYL PYRROLIDINE
  • S(-)-1-ETHYL-2-(AMINOMETHYL)PYRROLIDINE
  • S-(-)N-ETHYL-A-AMINOMETHYL-PYRROLIDINE
  • S-(-)-N-ETHYL-ALPHA-(AMINOMETHYL)PYRROLIDINE
  • 2-(Aminomethyl)-1-ethylpyrrolidine/N-ethyl-2-aminomethyl pyrrolidine
  • N-Ethyl-2-Aminoethyl Pyrrolidine
  • 1-ethylpyrrolidin-2-ylmethylamine
  • S-(-)N-METHYL-A-AININOMETHYL-PYPROLIDINE
  • [(1-Ethyl-2-pyrrolidinyl)methyl]amine
  • 1-Ethylpyrrolidine-2-methanamine
  • 2-(Aminomethyl)-1-ethylpyrrolidine,95%
  • C-(1-Ethyl-pyrrolidin-2-yl)-methylamine
  • 2-(AMinoMethyl)-1-ethylpyrrolidine, 95% 10GR
  • 2-(AMinoMethyl)-1-ethylpyrrolidine, 95% 50GR
  • N-Ethyl-2-aMinoMethyl pyrrollidine
  • 2-PyrrolidineMethanaMine,1-ethyl-
  • (2RS)-1-[ETHYLPYRROLIDINE-2-YL]-METHANAMINE
  • Amisulpride EP Impurity A (Sulpiride EP Impurity A)
  • Sulpiride EP Impurity A (Amisulpride EP Impurity A)
  • 2-(Aminomethyl)-1-ethylpyrrolidine (26116-12-1)
  • 2-(Aminomethyl)-1-ethylpyrrolidine (CAS : 26116-12-1)
  • 2-(Aminomethyl)-1-ethylpyrrolidine &gt
  • [(2RS)-1-Ethylpyrrolidin-2-yl]metha
  • Sulpiride impurity A CRS
  • )-1-ethyL
  • 1-Ethyl-2-aminomethyl pyrrolidine (EAP)
  • Amisulpride EP impurity AQ: What is Amisulpride EP impurity A Q: What is the CAS Number of Amisulpride EP impurity A Q: What is the storage condition of Amisulpride EP impurity A Q: What are the applications of Amisulpride EP impurity A
  • a . [(2RS)-1-e th ylpyrroli d i n-2-yl]me th a na mi ne ,
  • (Z)-[5-fluoro-2-methyl-1-[4-methylsulfanyl)benzylidene]-1H-inden-3-yl]acetic acid
  • Refer to S-402
  • N-ETHYL-2-AMINOMETHYL PYRROLIDINE (OTHER DETAIL AS PER INVOICE)
  • 2-(Aminomethyl)-1-ethylpyrrolidine - [A15585]
  • 2-(Aminomethyl)-1-Ethylpyrrolidine 2-()-1-
  • 26116-12-1
  • 26161-12-1
  • C7H16N2
  • Pyrrolidines
  • Heterocyclic Building Blocks
  • Chiral Building Blocks