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jnj39758979

Product Name
jnj39758979
CAS No.
1046447-90-8
Chemical Name
jnj39758979
Synonyms
jnj39758979;JNJ-39758979, 10 mM in DMSO;JNJ 39758979 (JNJ-39758979;(R)-4-(3-aminopyrrolidin-1-yl)-6-isopropylpyrimidin-2-amine;4-[(3R)-3-AMINOPYRROLIDIN-1-YL]-6-PROPAN-2-YLPYRIMIDIN-2-AMINE;2-Pyrimidinamine, 4-[(3R)-3-amino-1-pyrrolidinyl]-6-(1-methylethyl)-;agranulocytosis,histamine,JNJ-39758979,selective,toxicity,JNJ39758979,cAMP,inhibit,oral,Histamine Receptor,anti-inflammatory,Inhibitor,antipruritic,JNJ 39758979
CBNumber
CB53121976
Molecular Formula
C11H19N5
Formula Weight
221.3
MOL File
1046447-90-8.mol
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jnj39758979 Property

storage temp. 
4°C, protect from light
solubility 
Chloroform (Slightly), DMSO (Slightly, Sonicated)
form 
Solid
color 
Pale Beige to Light Beige
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
J212500
Product name
JNJ39758979
Packaging
1mg
Price
$60
Updated
2021/12/16
TRC
Product number
J212500
Product name
JNJ39758979
Packaging
2.5mg
Price
$85
Updated
2021/12/16
ChemScene
Product number
CS-0020957
Product name
JNJ-39758979
Purity
≥98.0%
Packaging
1mg
Price
$132
Updated
2021/12/16
ChemScene
Product number
CS-0020957
Product name
JNJ-39758979
Purity
≥98.0%
Packaging
5mg
Price
$396
Updated
2021/12/16
ChemScene
Product number
CS-0020957
Product name
JNJ-39758979
Purity
≥98.0%
Packaging
10mg
Price
$600
Updated
2021/12/16
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jnj39758979 Chemical Properties,Usage,Production

Uses

JNJ 39758979, is a selective, high-affinity histamine H4 receptor antagonist with a Ki of 12.5 nM.

in vivo

JNJ-39758979 (10 mg/kg; p.o.) treatment shows that the Cmax, t1/2 and F values are 0.3 μM, 7.5 hours, and 36%, respectively[1].
JNJ-39758979 (2 mg/kg; i.v.) treatment shows that the Vss, AUC, CL and t1/2 were 19.9 L/kg, 1.4 μM*h, 2.2 L/h, and 2.1 hours, respectively [1].

Animal Model:Sprague-Dawley rats[1]
Dosage:10 mg/kg
Administration:Oral administration (Pharmacokinetic Analysis)
Result:The Cmax, t1/2 and F values were 0.3 μM, 7.5 hours, and 36%, respectively.

IC 50

Human H4 Receptor: 12.5 nM (Ki); Mouse H4 Receptor: 5.3 nM (Ki); Monkey H4 receptor: 25 nM (Ki); Rat H4 receptor: 188 nM (Ki); Guinea pig H4 receptor: 306 nM (Ki)

jnj39758979 Preparation Products And Raw materials

Raw materials

Preparation Products

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jnj39758979 Suppliers

China 40 United States 6 Global 46
Nanjing Chemlin Chemical Co., Ltd
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025-83697070
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+86-25-83453306
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info@chemlin.com.cn
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China
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Taizhou Tongxin Bio-Tech Co., Ltd
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0523-86818997 18652728585
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sales@allyrise.com
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Shanghai Lollane Biological Technology Co.,Ltd.
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021-52996696，15000506266 15000506266
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+86-21-52996696
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China
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ShangHai Biochempartner Co.,Ltd
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177-54423994 17754423994
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QQ:2853530913
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2853530910@QQ.com
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China
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Shanghai Chaolan Chemical Technology Center
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021-QQ：65489617 15618227136
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21-5161 9052
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Sales@ATKchemical.com
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China
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Dezhou LonWel Pharmaceutical Technology Co., Ltd.
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13761310616
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QQ: 39324283
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39324283@qq.com
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China
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Tianjin Kaifu Pharmaceutical Technology Co., Ltd.
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18081075745
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chemflowtech@sina.com
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China
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TargetMol Chemicals Inc.
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+1-781-999-5354; +17819995354
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marketing@targetmol.com
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United States
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InvivoChem
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+1-708-310-1919 +1-13798911105
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708-557-7486
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sales@invivochem.cn
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HANGZHOU CLAP TECHNOLOGY CO.,LTD
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86-571-88216897,88216896 13588875226
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86-571-88216895
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sales@hzclap.com
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CHINA
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1046447-90-8, jnj39758979Related Search:

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  • jnj39758979
  • 4-[(3R)-3-AMINOPYRROLIDIN-1-YL]-6-PROPAN-2-YLPYRIMIDIN-2-AMINE
  • JNJ 39758979 (JNJ-39758979
  • 2-Pyrimidinamine, 4-[(3R)-3-amino-1-pyrrolidinyl]-6-(1-methylethyl)-
  • (R)-4-(3-aminopyrrolidin-1-yl)-6-isopropylpyrimidin-2-amine
  • agranulocytosis,histamine,JNJ-39758979,selective,toxicity,JNJ39758979,cAMP,inhibit,oral,Histamine Receptor,anti-inflammatory,Inhibitor,antipruritic,JNJ 39758979
  • JNJ-39758979, 10 mM in DMSO
  • 1046447-90-8