HLCL-61 (hydrochloride)

Product Name: HLCL-61 (hydrochloride)
CAS No.: 1158279-20-9
Chemical Name: HLCL-61 (hydrochloride)
Synonyms: CS-2798;HLCL-61.HCl;HLCL61;HLCL 61;HLCL-61 (hydrochloride);HLCL61;HLCL 61;HLCL 61 HYDROCHLORIDE;1-(9-Ethyl-9H-carbazol-3-yl)-N-(2-methoxybenzyl)methanamine hydrochloride;Histone Methyltransferase,HLCL 61,HLCL-61,inhibit,HLCL 61 hydrochloride,Apoptosis,HLCL61 hydrochloride,Inhibitor
CBNumber: CB53122928
Molecular Formula: C23H25ClN2O
Formula Weight: 380.92
MOL File: 1158279-20-9.mol

More

Less

HLCL-61 (hydrochloride) Property

storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: ≥20.4 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form: crystalline solid
color: White to off-white

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 19897
Product name: HLCL-61 (hydrochloride)
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 19897
Product name: HLCL-61 (hydrochloride)
Purity: ≥98%
Packaging: 5mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 19897
Product name: HLCL-61 (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $172
Updated: 2024/03/01

Cayman Chemical

Product number: 19897
Product name: HLCL-61 (hydrochloride)
Purity: ≥98%
Packaging: 25mg
Price: $321
Updated: 2024/03/01

ChemScene

Product number: CS-5600
Product name: HLCL-61(hydrochloride)
Purity: 99.98%
Packaging: 100mg
Price: $540
Updated: 2021/12/16

More

Less

HLCL-61 (hydrochloride) Chemical Properties,Usage,Production

Biological Activity

hlcl-61 is a prmt5 inhibitor.aberrant methylation of protein arginine residues mediated by protein arginine methyltransferase (prmt) enzymes is reported to be linked to cancer. prmts are a family of proteins with 11 known members catalyzing the transfer of methyl group(s) to the guanidine nitrogen atoms of peptide arginine residues. prmt5 has multiple substrates including histones and other non-chromatin proteins and has been gained attention for cancer therapy.

in vitro

in previous study, hlcl-61 showed no inhibitory activity against prmt1, prmt4, and type ii prmt family members, therefore demonstrating its specificity for prmt5. hlcl-61 also showed effective inhibition of symmetric arginine dimethylation of histones h3 and h4, starting at 12 h posttreatment and persisting for 48 h. moreover, the treatment of aml cell lines and primary blasts with hlcl-61 led to the decrease of cell viability. in addition, hlcl-61-treated aml cell lines and patient samples had induction of differentiation as demonstrated by dose-dependent increases in the expression of cd11b. furthermore, prmt5 inhibition caused by hlcl-61 treatment led to a decrease in mv4-11 cells [1].

target

Protein arginine methyltransferase 5

References

[1] tarighat ss et al. the dual epigenetic role of prmt5 in acute myeloid leukemia: gene activation and repression via histone arginine methylation. leukemia. 2016 apr;30(4):789-99.

HLCL-61 (hydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

HLCL-61 (hydrochloride) Suppliers

China 47 India 1 United States 9 Global 57

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

TargetMol Chemicals Inc.

Tel
Email: support@targetmol.com
Country: United States
ProdList: 38631
Advantage: 58

ApexBio Technology

Tel: --
Fax: --
Email: sales@apexbt.com
Country: United States
ProdList: 6251
Advantage: 58

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

Cayman Chemical Company

Tel: --
Fax: --
Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

MedChemExpress

Tel: --
Fax: --
Email: sales@medchemexpress.com
Country: United States
ProdList: 6398
Advantage: 58

1158279-20-9, HLCL-61 (hydrochloride)Related Search:

8-Ethyl-1,3,4,9-tetrahydro-1-methylpyrano[3,4-b]indole-1-acetic acid

HLCL-61 (hydrochloride)

HLCL-61.HCl

HLCL61;HLCL 61

CS-2798

HLCL61;HLCL 61;HLCL 61 HYDROCHLORIDE

1-(9-Ethyl-9H-carbazol-3-yl)-N-(2-methoxybenzyl)methanamine hydrochloride

Histone Methyltransferase,HLCL 61,HLCL-61,inhibit,HLCL 61 hydrochloride,Apoptosis,HLCL61 hydrochloride,Inhibitor

1158279-20-9

API