ChemicalBook > CAS DataBase List > 3-AMINO-5-TRIFLUOROMETHYL-BENZOIC ACID METHYL ESTER

3-AMINO-5-TRIFLUOROMETHYL-BENZOIC ACID METHYL ESTER

Product Name: 3-AMINO-5-TRIFLUOROMETHYL-BENZOIC ACID METHYL ESTER
CAS No.: 22235-25-2
Chemical Name: 3-AMINO-5-TRIFLUOROMETHYL-BENZOIC ACID METHYL ESTER
Synonyms: METHYL 3-AMINO-5-(TRIFLUOROMETHYL)BENZOATE;BUTTPARK 88\11-03;3-AMINO-5-TRIFLUOROMETHYL-BENZOIC ACID METHYL ESTER;Benzoic acid, 3-amino-5-(trifluoromethyl)-, methyl ester
CBNumber: CB5313657
Molecular Formula: C9H8F3NO2
Formula Weight: 219.16
MOL File: 22235-25-2.mol

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3-AMINO-5-TRIFLUOROMETHYL-BENZOIC ACID METHYL ESTER Property

storage temp.: Keep in dark place,Inert atmosphere,Room temperature
Appearance: Light brown to light yellow Solid

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Safety

HS Code: 2916399090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

H341Suspected of causing genetic defects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: M331418
Product name: Methyl3-Amino-5-(trifluoromethyl)benzoate
Packaging: 50mg
Price: $60
Updated: 2021/12/16

Apolloscientific

Product number: PC901522
Product name: Methyl3-amino-5-(trifluoromethyl)benzoate
Purity: 97%
Packaging: 5g
Price: $235
Updated: 2021/12/16

AK Scientific

Product number: W4584
Product name: Methyl3-amino-5-(trifluoromethyl)benzoate
Packaging: 5g
Price: $291
Updated: 2021/12/16

Apolloscientific

Product number: PC901522
Product name: Methyl3-amino-5-(trifluoromethyl)benzoate
Purity: 97%
Packaging: 10g
Price: $378
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0054582
Product name: METHYL 3-AMINO-5-(TRIFLUOROMETHYL)BENZOATE
Purity: 95.00%
Packaging: 1G
Price: $492
Updated: 2021/12/16

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3-AMINO-5-TRIFLUOROMETHYL-BENZOIC ACID METHYL ESTER Chemical Properties,Usage,Production

Synthesis

22227-63-0

22235-25-2

General procedure for the synthesis of methyl 3-amino-5-(trifluoromethyl)benzoate from methyl 3-nitro-5-trifluoromethylbenzoate: to a solution of methyl 3-nitro-5-(trifluoromethyl)benzoate (350 mg, 1.40 mmol) and tin(II) chloride dihydrate (1.58 g, 7.02 mmol) in methanol (20 mL) was added water (1 mL). The reaction mixture was stirred at 70 °C for 2 hours. After completion of the reaction, it was cooled to room temperature, the reaction solution was concentrated and quenched with saturated sodium bicarbonate solution. The reaction mixture was extracted with ethyl acetate (3 x 20 mL). The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated to afford methyl 3-amino-5-(trifluoromethyl)benzoate (300 mg, 98% yield) as a colorless solid.1H NMR (400 MHz, CDCl3): δ 7.65 (s, 1H), 7.48 (s, 1H), 7.05 (s, 1H), 3.99 (br s, 2H), 3.91 (s, 3H).

References

[1] Patent: WO2012/37132, 2012, A1. Location in patent: Page/Page column 47
[2] Patent: WO2007/4749, 2007, A1. Location in patent: Page/Page column 125
[3] Patent: US2012/71489, 2012, A1. Location in patent: Page/Page column 59
[4] Patent: US2007/249607, 2007, A1. Location in patent: Page/Page column 72
[5] Patent: WO2008/9435, 2008, A1. Location in patent: Page/Page column 159; 160

3-AMINO-5-TRIFLUOROMETHYL-BENZOIC ACID METHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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3-AMINO-5-TRIFLUOROMETHYL-BENZOIC ACID METHYL ESTER Suppliers

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View Lastest Price from 3-AMINO-5-TRIFLUOROMETHYL-BENZOIC ACID METHYL ESTER manufacturers

Career Henan Chemical Co

Product: 3-AMINO-5-TRIFLUOROMETHYL-BENZOIC ACID METHYL ESTER 22235-25-2
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1000KGS
Release date: 2019-12-24

22235-25-2, 3-AMINO-5-TRIFLUOROMETHYL-BENZOIC ACID METHYL ESTERRelated Search:

4-amino-3-trifluoromethyl-benzoic acid methyl ester 2-AMINO-4-TRIFLUOROMETHYL-BENZOIC ACID METHYL ESTER BUTTPARK 88\11-37 [3-AMINO-5-(TRIFLUOROMETHYL)PHENYL]METHANOL 3-Amino-5-(trifluoromethyl)benzoic acid 3-(Trifluoromethyl)benzoic acid 3-AMINO-5-TRIFLUOROMETHYL-BENZOIC ACID METHYL ESTER

3-AMINO-5-TRIFLUOROMETHYL-BENZOIC ACID METHYL ESTER

METHYL 3-AMINO-5-(TRIFLUOROMETHYL)BENZOATE

BUTTPARK 88\11-03

Benzoic acid, 3-amino-5-(trifluoromethyl)-, methyl ester

22235-25-2

pharmacetical