3-Amino-5-(trifluoromethyl)benzoic acid
- Product Name
- 3-Amino-5-(trifluoromethyl)benzoic acid
- CAS No.
- 328-68-7
- Chemical Name
- 3-Amino-5-(trifluoromethyl)benzoic acid
- Synonyms
- BUTTPARK 25\01-23;3-AMINO-5-(TRIFLUOROMETHYL)BENZOIC ACID;3-AMINO-5-(TRIFLUOROEMTHYL)BENZOIC ACID;3-Amino-5-(trifluoromethyl)benzoicacid97%;Benzoic acid, 3-amino-5-(trifluoromethyl)-;3-Amino-5-(trifluoromethyl)benzoic acid 97%;3-Amino-5-(trifluoromethyl)benzoic Acid >3-Amino-5-(trifluoromethyl)benzoic acid USP/EP/BP;3-Amino-5-carboxybenzotrifluoride, 3-Carboxy-5-(trifluoromethyl)aniline
- CBNumber
- CB6763695
- Molecular Formula
- C8H6F3NO2
- Formula Weight
- 205.13
- MOL File
- 328-68-7.mol
3-Amino-5-(trifluoromethyl)benzoic acid Property
- Melting point:
- 141-146 °C(lit.)
- Boiling point:
- 331.9±42.0 °C(Predicted)
- Density
- 1.489±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- powder to crystal
- pka
- 3.93±0.10(Predicted)
- color
- Light yellow to Yellow to Orange
- CAS DataBase Reference
- 328-68-7(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 579513
- Product name
- 3-Amino-5-(trifluoromethyl)benzoic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $60.1
- Updated
- 2025/07/31
- Product number
- A2481
- Product name
- 3-Amino-5-(trifluoromethyl)benzoic Acid
- Purity
- >97.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $226
- Updated
- 2024/03/01
- Product number
- A633455
- Product name
- 3-Amino-5-(trifluoromethyl)benzoic acid
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 001335
- Product name
- 3-Amino-5-(trifluoromethyl)benzoic acid
- Purity
- 97%
- Packaging
- 5g
- Price
- $47
- Updated
- 2021/12/16
- Product number
- PC1100CD
- Product name
- 3-Amino-5-(trifluoromethyl)benzoic acid
- Purity
- 97%
- Packaging
- 5g
- Price
- $56
- Updated
- 2021/12/16
3-Amino-5-(trifluoromethyl)benzoic acid Chemical Properties,Usage,Production
Uses
peptide synthesis
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
328-80-3
328-68-7
The suspension formed by 3-nitro-5-(trifluoromethyl)benzoic acid (103 g x 2 batches) obtained in step 1 and 10% palladium-carbon catalyst (5.15 g x 2 batches) in ethanol (1500 mL x 2 batches) was placed under the atmosphere of hydrogen at 1 atmospheric pressure, and the reaction was stirred for 7 hours at room temperature. After completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to afford the target product 3-amino-5-(trifluoromethyl)benzoic acid (180 g, 100% yield) as a light yellow powder. The product was characterized by 1H-NMR (300 MHz, CDCl3): δ 4.00-6.00 (2H, broad peak), 7.10 (1H, single peak), 7.53 (1H, single peak), 7.72 (1H, single peak).
References
[1] Patent: US2008/275085, 2008, A1. Location in patent: Page/Page column 45
[2] Chemistry - A European Journal, 2017, vol. 23, # 52, p. 12758 - 12762
[3] Patent: US2007/213371, 2007, A1. Location in patent: Page/Page column 70
[4] Journal of the American Chemical Society, 2017, vol. 139, # 43, p. 15308 - 15311
[5] Patent: WO2004/29038, 2004, A1. Location in patent: Page 44
3-Amino-5-(trifluoromethyl)benzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Amino-5-(trifluoromethyl)benzoic acid manufacturers
- Product
- 3-Amino-5-(trifluoromethyl)benzoic acid 328-68-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-11