3-NITRO-5-(TRIFLUOROMETHYL)BENZOIC ACID
- Product Name
- 3-NITRO-5-(TRIFLUOROMETHYL)BENZOIC ACID
- CAS No.
- 328-80-3
- Chemical Name
- 3-NITRO-5-(TRIFLUOROMETHYL)BENZOIC ACID
- Synonyms
- BUTTPARK 25\01-30;RARECHEM AL BO 1012;LABOTEST-BB LT00454389;3-CARBOXY-5-NITROBENZOTRIFLUORIDE;A,A,A-TRIFLUORO-5-NITRO-M-TOLUIC ACID;3-nitro-5-trifluoromethylbenzoic zoic;3-TRIFLUOROMETHYL-5-NITROBENZOIC ACID;5-(Trifluoromethyl)-3-nitrobenzoic acid;3-NITRO-5-(TRIFLUOROMETHYL)BENZOIC ACID;3-Nitro-5-(trifluoromethyl)benzoicacid97%
- CBNumber
- CB8434625
- Molecular Formula
- C8H4F3NO4
- Formula Weight
- 235.12
- MOL File
- 328-80-3.mol
3-NITRO-5-(TRIFLUOROMETHYL)BENZOIC ACID Property
- Melting point:
- 128 °C
- Boiling point:
- 309.9±42.0 °C(Predicted)
- Density
- 1.596±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 3.05±0.10(Predicted)
- color
- White to Light yellow to Light orange
- BRN
- 2284651
- CAS DataBase Reference
- 328-80-3(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39-60-37
- HazardClass
- IRRITANT
- HS Code
- 29163990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- S600679
- Product name
- 3-NITRO-5-(TRIFLUOROMETHYL)BENZOIC ACID
- Purity
- Aldrich<sup>CPR</sup>
- Packaging
- 1 unit
- Price
- $30.7
- Updated
- 2025/07/31
- Product number
- S600679
- Product name
- 3-NITRO-5-(TRIFLUOROMETHYL)BENZOIC ACID
- Purity
- Aldrich
- Packaging
- 250mg
- Price
- $29.8
- Updated
- 2024/03/01
- Product number
- T1344
- Product name
- 3-Trifluoromethyl-5-nitrobenzoic Acid
- Packaging
- 5g
- Price
- $115
- Updated
- 2025/07/31
- Product number
- T1344
- Product name
- 3-Trifluoromethyl-5-nitrobenzoic Acid
- Packaging
- 25g
- Price
- $457
- Updated
- 2025/07/31
- Product number
- T1344
- Product name
- 3-Trifluoromethyl-5-nitrobenzoic Acid
- Packaging
- 1g
- Price
- $33
- Updated
- 2021/12/16
3-NITRO-5-(TRIFLUOROMETHYL)BENZOIC ACID Chemical Properties,Usage,Production
Synthesis
454-92-2
328-80-3
The general procedure for synthesizing 3-nitro-5-(trifluoromethyl)benzoic acid from 3-trifluoromethylbenzoic acid is as follows: 1. 90% fuming nitric acid (210 mL) was slowly added to a solution of concentrated sulfuric acid (880 mL) of 3-trifluoromethylbenzoic acid (203.4 g) at 0 °C, and the addition process continued for 1 hour. 2. the reaction mixture was stirred at 35°C for 3 hours. 3. The reaction solution was slowly poured into ice (about 1 kg) to precipitate the product. 4. The precipitate was collected by filtration and washed with water (500 mL). 5. The precipitate was dissolved in ethyl acetate (500 mL) and the organic phase was washed with water. 6. After drying the organic phase, the solvent was evaporated under reduced pressure to give 3-nitro-5-(trifluoromethyl)benzoic acid (232.5 g, 92% yield) as a white powder. 1H-NMR (300MHz, CDCl3): δ 8.69 (1H, s), 8.74 (1H, s), 9.1 (1H, s).
References
[1] Patent: US2008/275085, 2008, A1. Location in patent: Page/Page column 45
[2] Journal of the American Chemical Society, 2017, vol. 139, # 43, p. 15308 - 15311
[3] Journal of Medicinal Chemistry, 2016, vol. 59, # 6, p. 2362 - 2380
[4] Angewandte Chemie - International Edition, 2017, vol. 56, # 8, p. 2059 - 2063
[5] Angew. Chem., 2017, vol. 129, # 8, p. 2091 - 2095,5
3-NITRO-5-(TRIFLUOROMETHYL)BENZOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-NITRO-5-(TRIFLUOROMETHYL)BENZOIC ACID manufacturers
- Product
- 3-NITRO-5-(TRIFLUOROMETHYL)BENZOIC ACID 328-80-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1kg,5kg,100kg
- Release date
- 2019-07-04