ChemicalBook > CAS DataBase List > 3-Amino-5-(trifluoromethyl)benzoic acid

3-Amino-5-(trifluoromethyl)benzoic acid

Product Name: 3-Amino-5-(trifluoromethyl)benzoic acid
CAS No.: 328-68-7
Chemical Name: 3-Amino-5-(trifluoromethyl)benzoic acid
Synonyms: BUTTPARK 25\01-23;3-AMINO-5-(TRIFLUOROMETHYL)BENZOIC ACID;3-AMINO-5-(TRIFLUOROEMTHYL)BENZOIC ACID;3-Amino-5-(trifluoromethyl)benzoicacid97%;Benzoic acid, 3-amino-5-(trifluoromethyl)-;3-Amino-5-(trifluoromethyl)benzoic acid 97%;3-Amino-5-(trifluoromethyl)benzoic Acid >3-Amino-5-(trifluoromethyl)benzoic acid USP/EP/BP;3-Amino-5-carboxybenzotrifluoride, 3-Carboxy-5-(trifluoromethyl)aniline
CBNumber: CB6763695
Molecular Formula: C8H6F3NO2
Formula Weight: 205.13
MOL File: 328-68-7.mol

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3-Amino-5-(trifluoromethyl)benzoic acid Property

Melting point:: 141-146 °C(lit.)
Boiling point:: 331.9±42.0 °C(Predicted)
Density: 1.489±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
form: powder to crystal
pka: 3.93±0.10(Predicted)
color: Light yellow to Yellow to Orange
CAS DataBase Reference: 328-68-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: DD6205700
HazardClass: IRRITANT
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 579513
Product name: 3-Amino-5-(trifluoromethyl)benzoic acid
Purity: 97%
Packaging: 1g
Price: $60.1
Updated: 2025/07/31

TCI Chemical

Product number: A2481
Product name: 3-Amino-5-(trifluoromethyl)benzoic Acid
Purity: >97.0%(HPLC)(T)
Packaging: 1g
Price: $226
Updated: 2024/03/01

TRC

Product number: A633455
Product name: 3-Amino-5-(trifluoromethyl)benzoic acid
Packaging: 10mg
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 001335
Product name: 3-Amino-5-(trifluoromethyl)benzoic acid
Purity: 97%
Packaging: 1g
Price: $13
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4857-3-35
Product name: 3-Amino-5-(trifluoromethyl)benzoic acid
Purity: 97%
Packaging: 1g
Price: $25
Updated: 2021/12/16

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3-Amino-5-(trifluoromethyl)benzoic acid Chemical Properties,Usage,Production

Uses

peptide synthesis

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

328-80-3

328-68-7

The suspension formed by 3-nitro-5-(trifluoromethyl)benzoic acid (103 g x 2 batches) obtained in step 1 and 10% palladium-carbon catalyst (5.15 g x 2 batches) in ethanol (1500 mL x 2 batches) was placed under the atmosphere of hydrogen at 1 atmospheric pressure, and the reaction was stirred for 7 hours at room temperature. After completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to afford the target product 3-amino-5-(trifluoromethyl)benzoic acid (180 g, 100% yield) as a light yellow powder. The product was characterized by 1H-NMR (300 MHz, CDCl3): δ 4.00-6.00 (2H, broad peak), 7.10 (1H, single peak), 7.53 (1H, single peak), 7.72 (1H, single peak).

References

[1] Patent: US2008/275085, 2008, A1. Location in patent: Page/Page column 45
[2] Chemistry - A European Journal, 2017, vol. 23, # 52, p. 12758 - 12762
[3] Patent: US2007/213371, 2007, A1. Location in patent: Page/Page column 70
[4] Journal of the American Chemical Society, 2017, vol. 139, # 43, p. 15308 - 15311
[5] Patent: WO2004/29038, 2004, A1. Location in patent: Page 44

3-Amino-5-(trifluoromethyl)benzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-Amino-5-(trifluoromethyl)benzoic acid manufacturers

Career Henan Chemical Co

Product: 3-Amino-5-(trifluoromethyl)benzoic acid 328-68-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-07-11

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328-68-7

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