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FOXY-5

Product Name
FOXY-5
CAS No.
881188-51-8
Chemical Name
FOXY-5
Synonyms
FOXY-5;Foxy-5 ，S6961;Foxy 5 trifluoroacetic acid;Foxy-5(Wnt5a peptide mimetic);Foxy 5 Discontinued (see F746005);L-Leucine, N-formyl-L-methionyl-L-α-aspartylglycyl-L-cysteinyl-L-α-glutamyl-;N-formyl-L-methionyl-L-alpha-aspartyl-glycyl-L-cysteinyl-L-alpha-glutamyl-L-leucine;(2S,5S,8R,14S)-5-(2-carboxyethyl)-14-((S)-2-formamido-4-(methylthio)butanamido)-2-isobutyl-8-(mercaptomethyl)-4,7,10,13-tetraoxo-3,6,9,12-tetraazahexadecane-1,16-dioic acid;(2S,5S,8R,14S)-5-(2-Carboxyethyl)-14-((S)-2-formamido-4-(methylthio)butancarboxcarboxcarboxamido)-2-isobutyl-8-(mercaptomethyl)-4,7,10,13-tetraoxo-3,6,9,12-tetraazahexadecan-1,16-dioic acid
CBNumber
CB53143800
Molecular Formula
C26H42N6O12S2
Formula Weight
694.77
MOL File
881188-51-8.mol
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FOXY-5 Property

Boiling point:
1244.1±65.0 °C(Predicted)
Density 
1.368±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Solid
pka
3.34±0.10(Predicted)
color 
White to off-white
Sequence
{For}-Met-Asp-Gly-Cys-Glu-Leu
InChIKey
WFZPJYYCTSHDJI-KMTCJHMQNA-N
SMILES
[C@H](CCC(=O)O)(C(=O)N[C@H](C(=O)O)CC(C)C)NC(=O)[C@H](CS)NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC=O)CCSC |&1:0,9,20,30,38,r|
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
5461
Product name
Foxy5
Packaging
1
Price
$151
Updated
2021/12/16
TRC
Product number
F746003
Product name
Foxy5Discontinued(seeF746005)
Packaging
1mg
Price
$135
Updated
2021/12/16
Usbiological
Product number
255329
Product name
Foxy 5
Packaging
1mg
Price
$389
Updated
2021/12/16
DC Chemicals
Product number
DC23893
Product name
Foxy-5(Wnt5apeptidemimetic)
Purity
>98%
Packaging
10mg
Price
$400
Updated
2021/12/16
DC Chemicals
Product number
DC23893
Product name
Foxy-5(Wnt5apeptidemimetic)
Purity
>98%
Packaging
25mg
Price
$650
Updated
2021/12/16
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FOXY-5 Chemical Properties,Usage,Production

Uses

Foxy 5 is a Wnt-5a-derived hexapeptide, which inhibits breast cancer metastasis in vivo by targeting cell motility.

Definition

ChEBI: (2S)-2-[[(2S)-4-carboxy-2-[[(2R)-2-[[2-[[(2S)-3-carboxy-2-[[(2S)-2-formamido-4-(methylthio)-1-oxobutyl]amino]-1-oxopropyl]amino]-1-oxoethyl]amino]-3-mercapto-1-oxopropyl]amino]-1-oxobutyl]amino]-4-methylpentanoic acid is a peptide.

in vivo

Foxy-5 (2 mg/kg intraperitoneally injected 9 times a day for 7-23 days) reduces the number of colon cancer stem cells in a mouse model of human colon cancer xenotransplantation[2].
Foxy-5 (2 mg/kg, intraperitoneal injection, once a day, for 3-9 weeks) significantly reduces the early metastasis and spread of WNT5A low DU145 prostate cancer cells in a mouse model of prostate cancer xenotransplantation[3].

Animal Model:A Xenograft Mouse Model of Human Colonic Cancer[2]
Dosage:2 mg/kg
Administration:i.p. 9 times a day for 7-23 days
Result:Reduced the expression of ALDH, DCLK1 and COX-2.
Increased the expression of 15-PGDH.
Reduced the expression of the downstream β-catenin target ASCL2.
Animal Model:A Xenograft Mouse Model of Prostate Cancer [3]
Dosage:2 mg/kg
Administration:i.p. once a day, for 3-9 weeks
Result:Reduced metastatic spread and the number of tumor cells in lymph nodes.

storage

Store at -20°C

FOXY-5 Preparation Products And Raw materials

Raw materials

Preparation Products

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FOXY-5 Suppliers

China 41 United Kingdom 1 United States 5 USA 1 Global 48
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19552
Advantage
58
Cato Research Chemicals Inc.
Tel
+86-020-81960175-877 4000-868-328
Email
tianwen.zhan@cato-chem.com
Country
United States
ProdList
10404
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
52923
Advantage
58
United States Biological
Tel
--
Fax
--
Email
sales@advtechind.com
Country
United States
ProdList
6075
Advantage
58
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
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View Lastest Price from FOXY-5 manufacturers

BOC Sciences
Product
Foxy-5 881188-51-8
Price
US $0.00/g
Min. Order
1g
Purity
98%
Supply Ability
1kg
Release date
2020-05-15

881188-51-8, FOXY-5Related Search:

L-Glutamine

  • FOXY-5
  • N-formyl-L-methionyl-L-alpha-aspartyl-glycyl-L-cysteinyl-L-alpha-glutamyl-L-leucine
  • L-Leucine, N-formyl-L-methionyl-L-α-aspartylglycyl-L-cysteinyl-L-α-glutamyl-
  • Foxy-5(Wnt5a peptide mimetic)
  • Foxy 5 Discontinued (see F746005)
  • (2S,5S,8R,14S)-5-(2-carboxyethyl)-14-((S)-2-formamido-4-(methylthio)butanamido)-2-isobutyl-8-(mercaptomethyl)-4,7,10,13-tetraoxo-3,6,9,12-tetraazahexadecane-1,16-dioic acid
  • Foxy 5 trifluoroacetic acid
  • Foxy-5 ，S6961
  • (2S,5S,8R,14S)-5-(2-Carboxyethyl)-14-((S)-2-formamido-4-(methylthio)butancarboxcarboxcarboxamido)-2-isobutyl-8-(mercaptomethyl)-4,7,10,13-tetraoxo-3,6,9,12-tetraazahexadecan-1,16-dioic acid
  • 881188-51-8
  • C26H42N6O12S2