Azide-PEG12-Tos
- Product Name
- Azide-PEG12-Tos
- CAS No.
- 1821464-56-5
- Chemical Name
- Azide-PEG12-Tos
- Synonyms
- N3-PEG12-Tos;Azide-PEG12-Tos;Azido-PEG12-Tos;Azide PEG12 Tos,AzidePEG12Tos,Inhibitor,Azide-PEG-12-Tos,PROTAC Linkers,inhibit;35-azido-3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontyl 4-methylbenzenesulfonate;N3-PEG12-Tos/3,6,9,12,15,18,21,24,27,30,33-Undecaoxapentatriacontan-1-ol, 35-azido-, 1-(4-methylbenzenesulfonate);2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate
- CBNumber
- CB53162854
- Molecular Formula
- C31H55N3O14S
- Formula Weight
- 725.85
- MOL File
- 1821464-56-5.mol
Azide-PEG12-Tos Property
- solubility
- Soluble in DMSO, DCM, DMF
N-Bromosuccinimide Price
- Product number
- BP-23149
- Product name
- Azide-PEG12-Tos
- Purity
- 98%
- Packaging
- 250mg
- Price
- $430
- Updated
- 2021/12/16
- Product number
- AS107799
- Product name
- N3-PEG12-Tos
- Purity
- 97%
- Packaging
- 1g
- Price
- $1126
- Updated
- 2021/12/16
- Product number
- B-1430
- Product name
- N3-PEG12-Tos
- Purity
- 97%
- Packaging
- 0.25g
- Price
- $366.67
- Updated
- 2021/12/16
- Product number
- B-1430
- Product name
- N3-PEG12-Tos
- Purity
- 97%
- Packaging
- 0.5g
- Price
- $550
- Updated
- 2021/12/16
Azide-PEG12-Tos Chemical Properties,Usage,Production
Description
Azide-PEG12-Tos is a monodisperse PEG reagent containing an azide group and a tosyl group. Long PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The tosyl group is a good leaving group for nucleophilic reactions.
Uses
Azide-PEG12-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azide-PEG12-Tos is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Azide-PEG12-Tos Preparation Products And Raw materials
Raw materials
Preparation Products
Azide-PEG12-Tos Suppliers
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View Lastest Price from Azide-PEG12-Tos manufacturers
- Product
- Azido-PEG12-Tos 1821464-56-5
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- >95.00%
- Supply Ability
- 1g
- Release date
- 2024-03-23