Azido-PEG12-NHS ester

Product Name: Azido-PEG12-NHS ester
CAS No.: 2363756-50-5
Chemical Name: Azido-PEG12-NHS ester
Synonyms: N3-PEG12-CH2CH2COONHS;Azido-PEG12-NHS eater;Azido PEG12 NHS ester,Azido-PEG-12-NHS ester,PROTAC Linkers,Inhibitor,AzidoPEG12NHS ester,inhibit
CBNumber: CB58054664
Molecular Formula: C31H56N4O16
Formula Weight: 740.8
MOL File: 2363756-50-5.mol

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Azido-PEG12-NHS ester Property

storage temp.: -20°C, sealed storage, away from moisture
solubility: Soluble in DMSO, DCM, DMF
form: Solid-Liquid Mixture
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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Azido-PEG12-NHS ester Chemical Properties,Usage,Production

Description

Azido-PEG12-NHS ester is a aqueous soluble crosslinker containing an azide group and an NHS ester. Ne azide can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.

Uses

Azido-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG12-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

PEGs; Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Azido-PEG12-NHS ester Preparation Products And Raw materials

Raw materials

Preparation Products

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Azido-PEG12-NHS ester Suppliers

China 23 United States 2 Global 25

Chengdu Pukang Biotechnology Co., Ltd

Tel: +86-028-82550498 +86-19102685862
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Xi'an Confluore Biological Technology Co., Ltd.

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Email: 1924344760@qq.com
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TargetMol Chemicals Inc.

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Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd

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TargetMol Chemicals Inc.

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Shanghai Yifei Biotechnology Co. , Ltd.

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View Lastest Price from Azido-PEG12-NHS ester manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: azido-PEG12-NHS ester 2363756-50-5
Price: US $0.00/g
Min. Order: 1g
Purity: >95.00%
Supply Ability: 1g
Release date: 2024-03-23

2363756-50-5, Azido-PEG12-NHS esterRelated Search:

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Azido PEG12 NHS ester,Azido-PEG-12-NHS ester,PROTAC Linkers,Inhibitor,AzidoPEG12NHS ester,inhibit

Azido-PEG12-NHS eater

N3-PEG12-CH2CH2COONHS

2363756-50-5