Azido-PEG12-NHS ester
- Product Name
- Azido-PEG12-NHS ester
- CAS No.
- 2363756-50-5
- Chemical Name
- Azido-PEG12-NHS ester
- Synonyms
- N3-PEG12-CH2CH2COONHS;Azido-PEG12-NHS eater;Azido PEG12 NHS ester,Azido-PEG-12-NHS ester,PROTAC Linkers,Inhibitor,AzidoPEG12NHS ester,inhibit
- CBNumber
- CB58054664
- Molecular Formula
- C31H56N4O16
- Formula Weight
- 740.8
- MOL File
- 2363756-50-5.mol
Azido-PEG12-NHS ester Property
- storage temp.
- -20°C, sealed storage, away from moisture
- solubility
- Soluble in DMSO, DCM, DMF
- form
- Solid-Liquid Mixture
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
Azido-PEG12-NHS ester Chemical Properties,Usage,Production
Description
Azido-PEG12-NHS ester is a aqueous soluble crosslinker containing an azide group and an NHS ester. Ne azide can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.
Uses
Azido-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG12-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
IC 50
PEGs; Alkyl/ether
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Azido-PEG12-NHS ester Preparation Products And Raw materials
Raw materials
Preparation Products
Azido-PEG12-NHS ester Suppliers
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View Lastest Price from Azido-PEG12-NHS ester manufacturers
- Product
- N3-PEG12-NHS 2363756-50-5
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 1g/bottle, 10g/bottle, 100g/bottle
- Release date
- 2026-02-04
- Product
- azido-PEG12-NHS ester 2363756-50-5
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- >95.00%
- Supply Ability
- 1g
- Release date
- 2024-03-23