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9-(BETA-D-ARABINOFURANOSYL)GUANINE

Product Name
9-(BETA-D-ARABINOFURANOSYL)GUANINE
CAS No.
38819-10-2
Chemical Name
9-(BETA-D-ARABINOFURANOSYL)GUANINE
Synonyms
Ara-G;Ara-Gr;Ara-rG;9-βNsc 76352;Ara G,AraG;Araguanosine;ara-Guanosine;Ara-G hydrate;arabinoguansine
CBNumber
CB5316537
Molecular Formula
C10H13N5O5
Formula Weight
283.24
MOL File
38819-10-2.mol
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9-(BETA-D-ARABINOFURANOSYL)GUANINE Property

Melting point:
225°C(lit.)
Density 
2.25±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,2-8°C
solubility 
DMSO: >10mg/mL
pka
9?+-.0.20(Predicted)
form 
solid
color 
White to Off-White
λmax
252nm(lit.)
InChI
InChI=1/C10H13N5O5/c11-10-13-7-4(8(19)14-10)12-2-15(7)9-6(18)5(17)3(1-16)20-9/h2-3,5-6,9,16-18H,1H2,(H3,11,13,14,19)/t3-,5-,6+,9-/s3
InChIKey
NYHBQMYGNKIUIF-FJFJXFQQSA-N
SMILES
O=C1NC(N)=NC2N([C@H]3[C@H]([C@H](O)[C@@H](CO)O3)O)C=NC1=2 |&1:8,9,10,12,r|
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26
WGK Germany 
3
RTECS 
MF8301000
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A4233
Product name
Ara-G hydrate
Purity
≥98% (HPLC), solid
Packaging
5mg
Price
$150
Updated
2025/07/31
Sigma-Aldrich
Product number
A4233
Product name
Ara-G hydrate
Purity
≥98% (HPLC), solid
Packaging
25mg
Price
$573
Updated
2025/07/31
TCI Chemical
Product number
A2739
Product name
9-beta-D-Arabinofuranosylguanine Hydrate
Purity
>98.0%(HPLC)
Packaging
10mg
Price
$55
Updated
2025/07/31
TCI Chemical
Product number
A2739
Product name
9-beta-D-Arabinofuranosylguanine Hydrate
Purity
>98.0%(HPLC)
Packaging
50mg
Price
$193
Updated
2025/07/31
Cayman Chemical
Product number
27984
Product name
Ara-G
Packaging
100mg
Price
$61
Updated
2024/03/01
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9-(BETA-D-ARABINOFURANOSYL)GUANINE Chemical Properties,Usage,Production

Description

Ara-G is an analog of the nucleoside guanosine and an active metabolite of nelarabine . Ara-G accumulates in T lymphoblasts and malignant T-lymphoid cells, where it is phosphorylated to produce ara-GTP and incorporated into the DNA. Ara-G inhibits DNA replication by 92% after 30 minutes when used at a concentration of 50 μM in CEM cells, which are used as a model for human T lymphoblasts. It also halts the cell cycle at the sub-G1 phase and induces apoptosis in CEM cells. Syngeneic bone marrow containing 6C3HED tumor cells treated with ara-G (100 mM) ex vivo prior to transplantation increases survival of lethally irradiated mice and induces reconstitution of lymphoid, myeloid, and erythroid cell linages.

Uses

Ara-G is an inducer of apoptosis, inhibitor of DNA synthesis, an antimetabolite, and antineoplastic.

Definition

ChEBI: A purine nucleoside in which guanine is attached to arabinofuranose via a beta-N9-glycosidic bond. It inhibits DNA synthesis and causes cell death.

References

[1] LUIGI LEANZA . Activation of guanine-β-d-arabinofuranoside and deoxyguanosine to triphosphates by a common pathway blocks T lymphoblasts at different checkpoints[J]. Experimental cell research, 2010, 316 20: Pages 3443-3453. DOI: 10.1016/j.yexcr.2010.06.023
[2] C U LAMBE. 2-Amino-6-methoxypurine arabinoside: an agent for T-cell malignancies.[J]. Cancer research, 1995, 55 15: 3352-3356.
[3] CARLOS O RODRIGUEZ  Varsha G  Christine M Stellrecht. Mechanisms for T-cell selective cytotoxicity of arabinosylguanine.[J]. Blood, 2003, 102 5: 1842-1848. DOI: 10.1182/blood-2003-01-0317
[4] KURTZBERG J. Guanine Arabinoside as a Bone Marrow-Purging Agenta[J]. Annals of the New York Academy of Sciences, 1993, 685 1: 225-236. DOI: 10.1111/j.1749-6632.1993.tb35870.x

9-(BETA-D-ARABINOFURANOSYL)GUANINE Preparation Products And Raw materials

Raw materials

Preparation Products

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9-(BETA-D-ARABINOFURANOSYL)GUANINE Suppliers

Americas 1 Canada 2 China 172 Europe 1 Finland 1 India 6 Japan 1 Poland 1 Switzerland 2 United Kingdom 7 United States 17 Global 211
Nanjing Baifuli Technology Co., Ltd.
Tel
25-25-58740604 15951658055
Fax
+86-25-58356858
Email
sales@unisyn.cn
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China
ProdList
591
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Xinxiang Meilin Biotechnology Co., LTD
Tel
15737397775; 15737397775
Email
970007865@qq.com
Country
China
ProdList
18
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58
microBioSyn Biotech Co,. Ltd.
Tel
153-0048-7802 15300487802
Email
jlin@microbiosyn.com
Country
China
ProdList
168
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58
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
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China
ProdList
96815
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Hongene Biotech Corporation
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021-64757213
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86-21-64700613
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info@hongene.com
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China
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672
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TCI (Shanghai) Development Co., Ltd.
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021-67121386
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021-67121385
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Sales-CN@TCIchemicals.com
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China
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24529
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Shanghai Sunway Pharmaceutical Technology Co., Ltd
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18270980682
Fax
021 51613951
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mlcheng@sunwaypharm.cn
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China
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8669
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Hangzhou Sage Chemical Co., Ltd.
Tel
+86057186818502 13588463833
Fax
Pls mail us for more information!
Email
info@sagechem.com
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China
ProdList
10266
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TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28387
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TCI Europe
Tel
320-37350700
Fax
+32 (0)37350701
Email
sales@tcieurope.eu
Country
Europe
ProdList
23671
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View Lastest Price from 9-(BETA-D-ARABINOFURANOSYL)GUANINE manufacturers

HANGZHOU HAILAN CHEMICAL CO.,LTD.
Product
9-(BETA-D-ARABINOFURANOSYL)GUANINE 38819-10-2
Price
US $0.00/kg
Min. Order
1kg
Purity
99%min
Supply Ability
20tons
Release date
2025-08-28
WUHAN FORTUNA CHEMICAL CO., LTD
Product
9-beta-D-Arabinofuranosylguanine Hydrate 38819-10-2
Price
US $0.00-0.00/g
Min. Order
1g
Purity
98.0%
Supply Ability
1kg/month
Release date
2021-10-13
Zhuozhou Wenxi import and Export Co., Ltd
Product
Arabinoguanosine 38819-10-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

38819-10-2, 9-(BETA-D-ARABINOFURANOSYL)GUANINERelated Search:

NADP sodium salt GUANINE-BETA-D-ARABINOFURANOSIDE, [8-3H]- 9-(2,3,5-TRI-O-BENZYL-BETA-D-ARABINOFURANOSYL)-GUANINE HYPOXANTHINE-9-BETA-D-ARABINOFURANOSIDE 9-(BETA-D-ARABINOFURANOSYL)GUANINE THYMINE-BETA-D-ARABINOFURANOSIDE Vidarabine Cytarabine 1-beta-D-Arabinofuranosyluracil

  • 9-beta-D-Arabinofuranosylguanine Hydrate
  • 2-AMino-9-((2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one
  • Arabinoguanosine
  • Araguanosine
  • ara-Guanosine
  • Guanine arabinoside
  • 9-β-D-Arabinofuranosyl guanine hydrate
  • 9-beta-Arabinosylguanine
  • 6H-Purin-6-one,2-amino-9-b-D-arabinofuranosyl-1,9-dihydro-
  • 2-amino-9-(beta-D-arabinofuranosyl)-3,9-dihydro-6H-purin-6-one
  • Ara-G hydrate, 98%, inhibitor of DNA synthesis, an antimetabolite and antineoplastic.
  • )-9-Bromo-8,9,10,11-tetrahydrobenz[a]anthracene-8,10,11-triol-d9
  • )-21-(Acetyloxy)-9,11-epoxy-6-fluoro-17-hydroxy-16-methylpregna-1,4-diene-3,20-dione
  • )-9,11-Epoxy-pregna-1,4,16-triene-3,20-dione
  • )-9,11-Epoxy-1,21-dihydroxy-4,16-dimethyl-19-norpregna-1,3,5(10)-trien-20-one
  • -Epoxy-21dehydroxy Betamethasone
  • )-9,11-Epoxy-21-hydroxy-16-methyl-pregna-1,4-diene-3,20-dione
  • )-21-(Acetyloxy)-9,11-epoxy-6-fluoro-16-methyl-d3-pregna-1,4-diene-3,20-dione
  • 9-&beta
  • 2-amino-9-beta-d-arabinofuranosyl-1,9-dihydro-6h-purin-6-on
  • 9-(beta-d-arabinofuranosyl)-guanin
  • 9-(BETA-D-ARABINOFURANOSYL)GUANINE
  • GUANINE-9-ARABINOSIDE
  • ARABINOFURANOSYL-GUANINE
  • 9-(b-D-Arabinofuranosyl)guanine
  • 9-arabinofuranosylguanine
  • ARA-G 9-(BETA-D-ARABINOFURANOSYL)-GUANINE
  • 2-Amino-9-β-D-arabinofuranosyl-1,9-dihydro-6H-purin-6-one
  • 2-Amino-9-β-D-arabinofuranosyl-9H-purine-6(1H)-one
  • 9-β-D-Arabinofuranosyl-1,6-dihydro-2-amino-6-oxo-9H-purine
  • 9-β-D-Arabinofuranosyl-2-amino-9H-purin-6-ol
  • Arabinosylguanine
  • Ara-G
  • Ara-G hydrate
  • 9-(β-D-Arabinoribofuranosyl)-guanine
  • 6H-Purin-6-one, 2-amino-9-beta-D-arabinofuranosyl-1,9-dihydro-
  • Guanine, 9-(beta-D-arabinofuranosyl)-
  • Nsc 76352
  • 9-(β-D-Arabinofuranosyl)guanine ,97%
  • -<small>D</small>-Arabinofuranosylguanine Hydrate
  • -methyl-pregn-4-ene-3,20-dione
  • )-21-(Acetyloxy)-9,11-epoxy-6-fluoro-pregna-1,4,16-triene-3,20-dione
  • -Epoxy-17,21-dihydroxy-16&beta
  • )-10-Bromo-8,9,10,11-tetrahydrobenz[a]anthracene-8,9,11-triol
  • )-21-(Acetyloxy)-9,11-epoxypregna-1,4,16-triene-3,20-dione
  • )-9,11-Epoxy-6-fluoro-21-hydroxy-16-methyl-pregna-1,4-diene-3,20-dione
  • )-9,11-Epoxy-6-fluoropregna-1,4,16-triene-3,20-dione
  • 1-β-D-Arabinofuranosylguanine
  • Ara-Gr
  • 9-β-D-Arabinofuranosylguanine Hydrate &gt
  • 6H-Purin-6-one, 2-amino-9-β-D-arabinofuranosyl-1,9-dihydro-
  • 9-β-D-Arabinofuranosylguanine
  • Arabinofuranosyl-guanine (ara-G)
  • 9-(BETA-D-ARABINOFURANOSYL)GUANINE USP/EP/BP
  • 9-β-D-Arabinofuranosylguanine Hydrate
  • 2-amino-9-(beta-D-arabinofuranosyl)-3,9-dihydro-6H-purin-6-o...
  • Ara G,AraG
  • Ara-rG