2-(2,5-dichlorophenyl)cyclohexa-2,5-diene-1,4-dione

Product Name: 2-(2,5-dichlorophenyl)cyclohexa-2,5-diene-1,4-dione
CAS No.: 79756-69-7
Chemical Name: 2-(2,5-dichlorophenyl)cyclohexa-2,5-diene-1,4-dione
Synonyms: TPI-1;TPI1;TPI 1;TPI-1,Inhibitor,inhibit,Phosphatase;2-(2,5-Dichlorophenyl)-1,4-benzoquinone;2',5'-Dichloro-[1,1'-biphenyl]-2,5-dione;2',5'-Dichloro-[1,1'-biphenyl]-2,5-dione;Recombinant Human TIM/TPI1 Protein, His Tag;2,5-Cyclohexadiene-1,4-dione, 2-(2,5-dichlorophenyl)-;2,5-Cyclohexadiene-1,4-dione, 2-(2,5-dichlorophenyl)-2-(2,5-dichlorophenyl)cyclohexa-2,5-diene-1,4-dione
CBNumber: CB53169525
Molecular Formula: C12H6Cl2O2
Formula Weight: 253.08
MOL File: 79756-69-7.mol

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2-(2,5-dichlorophenyl)cyclohexa-2,5-diene-1,4-dione Property

storage temp.: 2-8°C
solubility: DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 1 mg/ml
form: A crystalline solid

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Safety

HS Code: 2914698090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 22480
Product name: TPI-1
Purity: ≥95%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 22480
Product name: TPI-1
Purity: ≥95%
Packaging: 5mg
Price: $161
Updated: 2024/03/01

Cayman Chemical

Product number: 22480
Product name: TPI-1
Purity: ≥95%
Packaging: 10mg
Price: $283
Updated: 2024/03/01

Cayman Chemical

Product number: 22480
Product name: TPI-1
Purity: ≥95%
Packaging: 25mg
Price: $573
Updated: 2024/03/01

Usbiological

Product number: 359427
Product name: Tpi1
Packaging: 48Tests
Price: $588
Updated: 2021/12/16

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2-(2,5-dichlorophenyl)cyclohexa-2,5-diene-1,4-dione Chemical Properties,Usage,Production

Biological Activity

TPI-1 (Tyrosine Phosphatase Inhibitor 1) is a potent SHP-1 inhibitor with IC50 of 40 nM for recombinant SHP-1. It has anticancer activity.

in vitro

SHP-1 has been implicated as a potential cancer therapeutic target. TPI-1 is effective starting at 10 ng/mL in increasing SHP-1 phospho-substrates pLck-pY394. It selectively increases SHP-1 phospho-substrates (pLck-pY394, pZap70 and pSlp76) in Jurkat T cells but has little effects on pERK1/2 or pLck-pY505. TPI-1 induces mouse splenic-IFNγ ⁺ cells and induces IFNγ < sup> + cells in human peripheral blood.

in vivo

TPI-1 inhibits the growth of B16 melanoma tumors in mice at a tolerated oral dose in a T cell-dependent manner but has little effects on B16 cell growth in culture. It thus also increases pLck-pY394 and IFNγ ⁺ cells in mice. TPI-1 also inhibits B16 tumor growth and prolongs tumor mice survival as a tolerated sc agent.

target

Target	Value
SHP-1 (Cell-free assay)	40 nM

2-(2,5-dichlorophenyl)cyclohexa-2,5-diene-1,4-dione Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(2,5-dichlorophenyl)cyclohexa-2,5-diene-1,4-dione Suppliers

China 54 India 1 United Kingdom 1 United States 8 USA 1 Global 65

Shanghai Lollane Biological Technology Co.,Ltd.

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DC Chemicals

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79756-69-7, 2-(2,5-dichlorophenyl)cyclohexa-2,5-diene-1,4-dioneRelated Search:

TPI-1

2-(2,5-Dichlorophenyl)-1,4-benzoquinone

TPI1;TPI 1

2,5-Cyclohexadiene-1,4-dione, 2-(2,5-dichlorophenyl)-

Recombinant Human TIM/TPI1 Protein, His Tag

2',5'-Dichloro-[1,1'-biphenyl]-2,5-dione

TPI-1,Inhibitor,inhibit,Phosphatase

2',5'-Dichloro-[1,1'-biphenyl]-2,5-dione

2,5-Cyclohexadiene-1,4-dione, 2-(2,5-dichlorophenyl)-2-(2,5-dichlorophenyl)cyclohexa-2,5-diene-1,4-dione

79756-69-7