Nifekalant
- Product Name
- Nifekalant
- CAS No.
- 130636-43-0
- Chemical Name
- Nifekalant
- Synonyms
- NIFEKALANT;NIFEKALANT HCL;Nifekalant USP/EP/BP;OEBPANQZQGQPHF-UHFFFAOYSA-N;1-(3,4-dichlorophenyl)-3-hexylurea;6-[2-[2-hydroxyethyl-[3-(4-nitrophenyl)propyl]amino]ethylami...;6-((2-((2-hydroxyethyl)(3-(p-nitrophenyl)propyl)amino)ethyl)amino)-1,3-dimethyl-uracil;6-[2-[2-hydroxyethyl-[3-(4-nitrophenyl)propyl]amino]ethylamino]-1,3-dimethyl-pyrimidine-2,4-dione;6-[2-[2-hydroxyethyl-[3-(4-nitrophenyl)propyl]amino]ethylamino]-1,3-dimethyl-pyrimidine-2,4-quinone;NIFEKALANT [6-((2-((2-HYDROXYETHYL)(3-(P-NITROPHENYL)PROPYL)AMINO)ETHYL)AMINO)-1,3-DIMETHYL-URACIL]
- CBNumber
- CB5325412
- Molecular Formula
- C19H27N5O5
- Formula Weight
- 405.45
- MOL File
- 130636-43-0.mol
Nifekalant Property
- Melting point:
- 117.5-118.5°; mp 125-126° (Katakami, 1992)
- Boiling point:
- 597.9±60.0 °C(Predicted)
- Density
- 1.32±0.1 g/cm3(Predicted)
- pka
- 14.74±0.10(Predicted)
- CAS DataBase Reference
- 130636-43-0(CAS DataBase Reference)
N-Bromosuccinimide Price
- Product number
- API0015401
- Product name
- NIFEKALANT
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.39
- Updated
- 2021/12/16
- Product number
- MT-56993
- Product name
- Nifekalant
- Purity
- 98%
- Packaging
- 0.25g
- Price
- $560
- Updated
- 2021/12/16
Nifekalant Chemical Properties,Usage,Production
Uses
Nifekalant (MS-551), a class III antiarrhythmic agent, is a IKr potassium channel blocker with an IC50 of 10 μM. Nifekalant can be used for refractory ventricular tachyarrhythmias research[1][2].
Definition
ChEBI: Nifekalant is an amine.
in vivo
In rats (a species deficient in functional cardiac IK), before coronary ligation, 3 mg/kg and 10 mg/kg MS-551 decreased the heart rate by 6% and 12%, and increased mean arterial pressure (MAP) by 14% and 33%, respectively. MS-551 prolongs the QT interval and reduced the incidence of sustained ventricular fibrillation (VF) after reperfusion[3].
References
[1] Lü-Pei Du, et al. The pharmacophore hypotheses of I(Kr) potassium channel blockers: novel class III antiarrhythmic agents. Bioorg Med Chem Lett. 2004 Sep 20;14(18):4771-7. DOI:10.1016/j.bmcl.2004.06.070
[2] Ioannis N Pantazopoulos, et al. Nifekalant in the treatment of life-threatening ventricular tachyarrhythmias. World J Cardiol. 2011 Jun 26;3(6):169-76. DOI:10.4330/wjc.v3.i6.169
[3] J Chen, et al. IK independent class III actions of MS-551 compared with sematilide and dofetilide during reperfusion in anaesthetized rats. Br J Pharmacol. 1996 Nov;119(5):937-42. DOI:10.1111/j.1476-5381.1996.tb15762.x
Nifekalant Preparation Products And Raw materials
Raw materials
Preparation Products
Nifekalant Suppliers
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View Lastest Price from Nifekalant manufacturers
- Product
- Nifekalant 130636-43-0
- Price
- US $1.00/KG
- Min. Order
- 1G
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-08-20