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tert-Butyl 4-aminobenzoate

Product Name
tert-Butyl 4-aminobenzoate
CAS No.
18144-47-3
Chemical Name
tert-Butyl 4-aminobenzoate
Synonyms
BUTTPARK 14\02-67;tert-Butyl 4-aminobe;ert-butyl4-aminobenzoate;Tert-Butyl p-aMinobenzoate;TERT-BUTYL 4-AMINOBENZOATE;tert-butyl 4-azanylbenzoate;4-(tert-Butoxycarbonyl)aniline;tert-Butyl 4-Aminobenzoate >1,1-Dimethylethyl 4-aminobenzoate;4-AMINOBENZOIC ACID TERT-BUTYL ESTER
CBNumber
CB5329814
Molecular Formula
C11H15NO2
Formula Weight
193.24
MOL File
18144-47-3.mol
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tert-Butyl 4-aminobenzoate Property

Melting point:
108-110 °C
Boiling point:
322.4±15.0 °C(Predicted)
Density 
1.078±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
form 
powder to crystal
pka
2.43±0.10(Predicted)
color 
White to Light yellow to Light orange
BRN 
2803178
CAS DataBase Reference
18144-47-3(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
F 
10-34
Hazard Note 
Irritant
HS Code 
29224999
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
06975
Product name
tert-Butyl 4-aminobenzoate
Purity
≥98.0% (NT)
Packaging
5g
Price
$97.2
Updated
2024/03/01
Sigma-Aldrich
Product number
06975
Product name
tert-Butyl 4-aminobenzoate
Purity
≥98.0% (NT)
Packaging
25g
Price
$375
Updated
2024/03/01
TCI Chemical
Product number
B3504
Product name
tert-Butyl 4-Aminobenzoate
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$80
Updated
2024/03/01
TCI Chemical
Product number
B3504
Product name
tert-Butyl 4-Aminobenzoate
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$228
Updated
2024/03/01
TRC
Product number
B809723
Product name
tert-Butyl 4-Aminobenzoate
Packaging
50mg
Price
$45
Updated
2021/12/16
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tert-Butyl 4-aminobenzoate Chemical Properties,Usage,Production

Uses

tert-Butyl 4-aminobenzoate can be used to synthesise structural units for antifolate and a novel liver-targeted coupling of PSN-357, a glycogen phosphorylase inhibitor for the treatment of diabetes. It can also be used in the synthesis of tert-butyl 4-aminobenzoate n-substituted derivatives[1].

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

tert-Butyl 4-aminobenzoate is synthesised using tert-butyl 4-nitrobenzoate as raw material by chemical reaction. The specific synthesis steps are as follows:
Tert-butyl 4-nitrobenzoate (4.75 g, 21.279 mmol) was dissolved in MeOH (200 ml) and added with CAUTION was Pd/C (475 mg, 0.1 equiv. w/w) and the flask evacuated prior to purging with N2, re-evacuation and purging with H2. The mixture was stirred under H2 for 5 hours until complete. The mixture was filtered through celite and evaporated to a white solid (4.11 g, 21.269 mmol, quant.). Rf 0.29 [20% EtOAc in Hexane]. Mp. I l l - 113 0C. 1H NMR (400 MHz, CDCl3) δ 7.79 (2H, dt, J=8.6, 2.3 Hz, 2ArH), 6.61 (2H, dt, J=8.6, 2.3 Hz, 2ArH), 4.00 (2H, br s, NH2), 1.56 (9H, s, C(CH3)3) ppm. 13C NMR (100 MHz, CDCl3) δ 165.9 (C=O), 150.4 (ArC), 131.3 (ArCH), 121.7 (ArC), 113.7 (ArCH), 80.0 (C(CH3)3), 28.3 (C(CH3)3) ppm. IR (neat) υmax 3415, 3345, 3235, 2972, 1682, 1598, 1367, 1287, 1154, 1115 cm 1. HRMS mJz calc. C11H15NO2 [M+l] 194.1176, found [M+l] 194.1179.

References

[1] V. BAVETSIAS  E. H. Synthesis of N-substituted derivatives of tert-butyl 4-aminobenzoate via a palladium-catalysed reaction[J]. Journal of Chemical Research-s, 2000. DOI:10.3184/030823400103168100.

tert-Butyl 4-aminobenzoate Preparation Products And Raw materials

Raw materials

Preparation Products

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tert-Butyl 4-aminobenzoate Suppliers

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View Lastest Price from tert-Butyl 4-aminobenzoate manufacturers

Wuhan Circle Star Chem-medical Technology Co.,Ltd
Product
tert-Butyl 4-aminobenzoate 18144-47-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98
Supply Ability
1000
Release date
2025-01-15
WUHAN FORTUNA CHEMICAL CO., LTD
Product
tert-Butyl 4-aminobenzoate 18144-47-3
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
500kgs
Release date
2023-05-16
hebei hongtan Biotechnology Co., Ltd
Product
Tert-Butyl 4-aminobenzoate 18144-47-3
Price
US $30.00-20.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1000kg
Release date
2024-05-16

18144-47-3, tert-Butyl 4-aminobenzoateRelated Search:

Butyl acetate Cyhalofop-butyl 2-Butoxyethanol Methyl 4-aminobenzoate Butyl 4-aminobenzoate tert-Butanol p-Aminobenzamide BUTYL OLEATE Methyl anthranilate tert-Butyl peroxyacetate P-AMINOBENZOIC ACID POTASSIUM SALT Butyl acrylate Diethylene glycol monobutyl ether tert-Butyl peroxybenzoate 4-Aminobenzoic acid P-AMINOBENZAMIDE GLUTAMIC ACID 4-AMINOBENZOIC ACID SODIUM SALT Buprofezin

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  • 18144-47-3
  • 18114-47-3
  • C11H15NO2
  • Aromatic Amino Acids
  • Specialty Synthesis
  • Peptide Synthesis
  • Unnatural Amino Acid Derivatives
  • API intermediates
  • Aromatic Amino Acids
  • Peptide Synthesis
  • Unnatural Amino Acid Derivatives