ChemicalBook > CAS DataBase List > Indol-1-yl-acetic acid

Indol-1-yl-acetic acid

Product Name
Indol-1-yl-acetic acid
CAS No.
24297-59-4
Chemical Name
Indol-1-yl-acetic acid
Synonyms
Ai3-62651;VITAS-BB TBB000210;N-lindolaceticacid;INDOLE-1-ACETIC ACID;N-indole acetic acid;1- Indole Acetic acid;INDOL-1-YL-ACETIC ACID;(1-Indolyl)acetic Acid;1-Indoleaceticacid,95%;1H-INDOLE-1-ACETIC ACID
CBNumber
CB5333895
Molecular Formula
C10H9NO2
Formula Weight
175.18
MOL File
24297-59-4.mol
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Indol-1-yl-acetic acid Property

Melting point:
168.0 to 172.0 °C
Boiling point:
384.5±25.0 °C(Predicted)
Density 
1.23±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Acetone (Slightly), DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
4.31±0.10(Predicted)
color 
Light Orange to Dark Orange
CAS DataBase Reference
24297-59-4(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
HazardClass 
IRRITANT
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S547115
Product name
1-INDOLEACETIC ACID
Purity
Aldrich<sup>CPR</sup>
Packaging
1 unit
Price
$185
Updated
2025/07/31
Sigma-Aldrich
Product number
S547115
Product name
1-INDOLEACETIC ACID
Purity
Aldrich
Packaging
50mg
Price
$179
Updated
2024/03/01
TCI Chemical
Product number
I0932
Product name
(1-Indolyl)acetic Acid
Purity
>97.0%(T)
Packaging
1g
Price
$46
Updated
2025/07/31
TCI Chemical
Product number
I0932
Product name
(1-Indolyl)acetic Acid
Purity
>97.0%(T)
Packaging
5g
Price
$114
Updated
2025/07/31
Apolloscientific
Product number
OR930357
Product name
Indol-1-yl-aceticacid
Purity
96%
Packaging
10g
Price
$310
Updated
2021/12/16
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Indol-1-yl-acetic acid Chemical Properties,Usage,Production

Uses

Indol-1-yl-acetic Acid is a reactant used in the preparation of conformationally restrained analogs of pravadoline; nanomolar potent, enantioselective, (aminoalkyl)?indole agonists of the cannabinoid receptor.

Definition

ChEBI: An indolyl carboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by an indol-1-yl group.

Synthesis

61155-69-9

24297-59-4

Step 2: Preparation of 2-(1H-indol-1-yl)acetic acid Ethyl 2-(1H-indol-1-yl)acetate (2.03 g, 10 mmol) was dissolved in ethanol (40 mL), aqueous sodium hydroxide solution (1 N, 50 mL) was added, and the reaction was stirred at room temperature for 1.5 hours. Upon completion of the reaction, the reaction solution was adjusted to slightly acidic with dilute hydrochloric acid and the mixture was subsequently concentrated under reduced pressure. The residue was extracted with ethyl acetate and the organic phase was washed with brine and the solvent was removed under reduced pressure to give pure 2-(1H-indol-1-yl)acetic acid (1.6 g, 87% yield), (LC/MS: m/z = 176.3 [M+H]+).

References

[1] Patent: WO2015/106025, 2015, A1. Location in patent: Paragraph 0334
[2] Patent: US2016/326123, 2016, A1. Location in patent: Paragraph 0546
[3] Journal of Heterocyclic Chemistry, 1984, vol. 21, p. 975 - 976
[4] European Journal of Medicinal Chemistry, 1989, vol. 24, p. 145 - 154
[5] Patent: WO2006/55725, 2006, A2. Location in patent: Page/Page column 188-189

Indol-1-yl-acetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Indol-1-yl-acetic acid manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
Indol-1-yl-acetic acid 24297-59-4
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-13
Career Henan Chemical Co
Product
Indol-1-yl-acetic acid 24297-59-4
Price
US $1.00/KG
Min. Order
1KG
Purity
95-99%
Supply Ability
1ton
Release date
2020-01-08

24297-59-4, Indol-1-yl-acetic acidRelated Search:

Indole Ethyl 2-(Chlorosulfonyl)acetate Indole-3-acetic acid Indometacin Indole-3-butyric acid INDOLE-2-ACETIC ACID METHYL 3-INDOLYLACETATE Indole-2-carboxylic acid 3-Indolepropionic acid 3-Indoleacetonitrile Indole-3-carbinol Indole-5-carboxylic acid Methyl indole-5-carboxylate Indole-4-carboxylic acid Methyl 1H-indole-7-carboxylate Indole-6-carboxaldehyde Methyl indole-2-carboxylate Methyl indole-4-carboxylate

  • VITAS-BB TBB000210
  • ASINEX-REAG BAS 12457638
  • INDOLE-1-ACETIC ACID
  • INDOL-1-YL-ACETIC ACID
  • 1H-INDOLE-1-ACETIC ACID
  • 2-(1H-Indol-1-yl)acetic acid
  • 1H-indol-1-ylacetic acid
  • Ai3-62651
  • 1- Indole Acetic acid
  • N-indole acetic acid
  • (1-Indolyl)acetic Acid
  • 1H-indol-1-ylacetic acid(SALTDATA: FREE)
  • N-lindolaceticacid
  • 2-(1-indolyl)acetic acid
  • 2-indol-1-ylacetic acid
  • 2-indol-1-ylethanoic acid
  • (1-Indolyl)acetic Acid &gt
  • 1-Indoleaceticacid,95%
  • 1H-Indole-1-acetic acid (9CI, ACI)
  • 24297-59-4
  • API intermediates