Tetradecyltrimethylammonium bromide Property

Melting point:

245-250 °C(lit.)

Density 

1.1328 (rough estimate)

vapor pressure 

0Pa at 25℃

refractive index 

1.5260 (estimate)

storage temp. 

Store below +30°C.

solubility 

DMF: 2 mg/ml DMSO: 16 mg/ml Ethanol: 33 mg/ml PBS (pH 7.2): 5 mg/ml

form 

Fine Crystalline Powder

color 

White

PH

pH (50g/l, 25℃ : 4.0～6.0

Water Solubility 

H2O:10%(w/v) 20 g/100 mL

λmax

λ: 240 nm Amax: ≤0.08
λ: 250 nm Amax: ≤0.05
λ: 260 nm Amax: ≤0.04
λ: 500 nm Amax: ≤0.02

Sensitive 

Hygroscopic

Merck 

14,6336

BRN 

3633227

Stability:

Stable. Hygroscopic. Incompatible with strong oxidizing agents.

InChIKey

CXRFDZFCGOPDTD-UHFFFAOYSA-M

LogP

2.2 at 20℃

CAS DataBase Reference

1119-97-7(CAS DataBase Reference)

EPA Substance Registry System

Tetradecyl trimethyl ammonium bromide (1119-97-7)

Safety

Hazard Codes 

C

Risk Statements 

34

Safety Statements 

26-36/37/39-45-27

RIDADR 

UN 3263 8/PG 2

WGK Germany 

3

RTECS 

BS5776000

F 

3

TSCA 

Yes

HazardClass 

8

PackingGroup 

II

HS Code 

29239000

Toxicity

LD50 in mice, rats (mg/kg): 12.0, 15.0 i.v. (Issomaa, Bjondahl)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

H373May cause damage to organs through prolonged or repeated exposure

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P314Get medical advice/attention if you feel unwell.

Tetradecyltrimethylammonium bromide Chemical Properties,Usage,Production

Physical properties

Cetrimide is a white fine powder crystal with a melting point of 245°C to 250°C. A rough estimate of its density is 1.1328. It is soluble in water with a solubility of 20 g/100 mL.

Description

MiTMAB (1119-97-7) is a dynamin I/II inhibitor targeting the dynamin-phospholipid interaction and inhibiting dynamin GTPase activity with a Ki=940nM.1 Rapidly and reversibly inhibits multiple forms of endocytosis with no acute cellular damage1. A useful pharmacological tool for studying dynamin-mediated trafficking events.2 Induces cytokinesis failure and apoptosis in human cancer cells.3 Induces cytoprotective autophagy in human Jurkat T cells.4

Uses

Disinfectant; deodorant; laboratory reagent.

Uses

Myristyltrimethylammonium has been used in a study to assess a surfactant-controlled synthetic method to obtain a nanophase of mesoporous ceria-zirconia solid solution containing cationic defects in the crystalline structure.??It has also been used in a study to determine the low molecular weight of organic acids in soils and plants by capillary zone electrophoresis.

Definition

Myristyltrimethylammonium bromide is an organic molecular entity.

General Description

Myristyltrimethylammonium bromide is a cationic/zwitterionic type of surfactant.

Purification Methods

Crystallise the bromide from acetone or a mixture of Me2CO and >5% MeOH or Me2CO/EtOH. Wash it with diethyl ether and dry it in a vacuum oven at 60o. It is a cationic detergent. Its solubility is 1g/5g H2O. [Dearden & Wooley J Phys Chem 91 2404 1987, Shelton et al. J Am Chem Soc 68 754 1946, Beilstein 4 III 419, 4 IV 813.]

References

1) ANNIE QUAN. Myristyl trimethyl ammonium bromide and octadecyl trimethyl ammonium bromide are surface-active small molecule dynamin inhibitors that block endocytosis mediated by dynamin I or dynamin II.[J]. Molecular Pharmacology, 2007, 72 6: 1425-1439. DOI:10.1124/mol.107.034207.
2) SAMIR VYAS. Development and validation of a stability indicating method for the enantioselective estimation of omeprazole enantiomers in the enteric-coated formulations by high-performance liquid chromatography.[J]. Journal of Pharmacy and Bioallied Sciences, 2011, 3 2: 310-314. DOI:10.4103/0975-7406.80766.
3) SIMON DE BECO. Endocytosis is required for E-cadherin redistribution at mature adherens junctions.[J]. ACS Catalysis , 2009: 7010-7015. DOI:10.1073/pnas.0811253106.
4) YOON HEE KIM . Inhibition of autophagy enhances dynamin inhibitor-induced apoptosis via promoting Bak activation and mitochondrial damage in human Jurkat T cells[J]. Biochemical and biophysical research communications, 2016, 478 4: Pages 1609-1616. DOI:10.1016/j.bbrc.2016.08.165.