4-(7-methoxyquinolin-4-yl)-2-methylphenol
- Product Name
- 4-(7-methoxyquinolin-4-yl)-2-methylphenol
- CAS No.
- 2165340-32-7
- Chemical Name
- 4-(7-methoxyquinolin-4-yl)-2-methylphenol
- Synonyms
- CU-CPT-9b;cas 2165340-32-7;CU-CPT-9B, CPD2004;CU-CPT9a >=98% (HPLC);CU-CPT-9a, 10 mM in DMSO;2-Methyl-4-(7-methoxy-4-quinolinyl)phenol;4-(7-methoxyquinolin-4-yl)-2-methylphenol;CU-CPT-9B;CAS 2165340-32-7 ;TLR8 INHIBITOR;Phenol, 4-(7-methoxy-4-quinolinyl)-2-methyl-;Toll-like Receptor (TLR),inhibit,Inhibitor,CU CPT 9a,CUCPT9a
- CBNumber
- CB53369684
- Molecular Formula
- C17H15NO2
- Formula Weight
- 265.31
- MOL File
- 2165340-32-7.mol
4-(7-methoxyquinolin-4-yl)-2-methylphenol Property
- Boiling point:
- 429.7±45.0 °C(Predicted)
- Density
- 1.201±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml; DMSO: 10 mg/ml; Ethanol: 5 mg/ml
- form
- A crystalline solid
- pka
- 8.47±0.20(Predicted)
- color
- Light yellow to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 28722
- Product name
- CU-CPT9a
- Packaging
- 5mg
- Price
- $100
- Updated
- 2024/03/01
- Product number
- 28722
- Product name
- CU-CPT9a
- Packaging
- 25mg
- Price
- $381
- Updated
- 2024/03/01
- Product number
- 28722
- Product name
- CU-CPT9a
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 28722
- Product name
- CU-CPT9a
- Packaging
- 10mg
- Price
- $184
- Updated
- 2024/03/01
- Product number
- C852008
- Product name
- CU-CPT9a
- Packaging
- 2.5mg
- Price
- $130
- Updated
- 2021/12/16
4-(7-methoxyquinolin-4-yl)-2-methylphenol Chemical Properties,Usage,Production
Uses
CU-CPT9a is a potent TLR8 inhibitor (IC50 = 0.5 nM and Kd = 21 nM). Stabilizes the TLR8 dimer in its resting state, preventing activation. Suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells.
Biological Activity
CU-CPT9a is a potent and selective inhibitor of Toll-like receptor 8 (TLR8). It binds to TLR8 at a site different from current small-molecule TLR7/8 agonists, stabilizing the TLR8 dimer in its resting state, thus preventing TLR8 activation It exhibited an IC50 value of 0.5 nM and blocked TLR8 activation induced by either resiquimod (R848) or ssRNA without affecting the closely related TLR7 or cells expressing other TLRs. CU-CPT9a also suppressed TNF-α levels in a dose-dependent manner in cells from patients with rheumatoid arthritis.
storage
Store at -20°C
4-(7-methoxyquinolin-4-yl)-2-methylphenol Preparation Products And Raw materials
Raw materials
Preparation Products
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