2-METHYL-3-PHENYL-2-PROPEN-1-OL Property

Melting point:

24-25 °C(Solv: ligroine (8032-32-4))

Boiling point:

77 °C0.1 mm Hg(lit.)

Density 

1.03 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.572(lit.)

Flash point:

>230 °F

solubility 

Almost insoluble in water, soluble in alcohol and oils.?

pka

14?+-.0.10(Predicted)

form 

powder to lump to clear liquid

color 

White or Colorless to Light yellow

Odor

at 100.00 %. sweet balsam floral oriental styrax

Odor Type

balsamic

LogP

1.929 (est)

EPA Substance Registry System

2-Propen-1-ol, 2-methyl-3-phenyl- (1504-55-8)

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39

WGK Germany 

2

RTECS 

GE2340000

HS Code 

2906290090

Toxicity

The acute oral LD₅₀ in rats was reported as 2.4 ml/kg (1.9-3.0 ml/kg) (Levenstein, 1974). The acute dermal LD₅₀ in rabbits exceeded 5 g/kg (Levenstein, 1974).

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

2-METHYL-3-PHENYL-2-PROPEN-1-OL Chemical Properties,Usage,Production

Occurrence

Has apparently not been reported to occur in nature

Uses

trans-2-Methyl-3-phenyl-2-propen-1-ol was used in the preparation of 5-methyl-4-phenyl-5-hexen-2-one.

Preparation

By selective hydrogenation of methylcinnamic aldehyde

Synthesis Reference(s)

Journal of the American Chemical Society, 117, p. 10417, 1995 DOI: 10.1021/ja00146a041

Metabolism

Cinnamic alcohol is mainly metabolized to benzoic acid, presumably via cinnamic acid, but substitution apparently prevents oxidation to benzoic acid, since 2-ethylcinnamic alcohol ( C 6H 5CH:C(C 2H 5)CH 2O H ) is partly (30-33%) excreted as α-ethylcinnamic acid (Williams, 1959)