Z-CIS-HYP-OH
- Product Name
- Z-CIS-HYP-OH
- CAS No.
- 13504-86-4
- Chemical Name
- Z-CIS-HYP-OH
- Synonyms
- Z-CIS-HYP-OH;Z-L-CIS-HYP-OH;Z-cis-L-Hyp-OH;CBZ-cis-Hyp-OH;Z-CIS-HYDROXYPROLINE;Z-L-CIS-4-HYDROXYPROLINE;Z-CIS-4-HYDROXY-L-PROLINE;Z-L-cis-4-hydroxyproline99%;cis-N-Cbz-4-hydroxy-L-proline;N-Cbz-4-cis-Hydroxy-L-proline
- CBNumber
- CB5349906
- Molecular Formula
- C13H15NO5
- Formula Weight
- 265.26
- MOL File
- 13504-86-4.mol
Z-CIS-HYP-OH Property
- Boiling point:
- 486.9±45.0 °C(Predicted)
- Density
- 1.416±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 3.78±0.40(Predicted)
- Appearance
- White to off-white Solid
- optical activity
- -37.8°(C=0.01g/ml MEOH)
Safety
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 242772
- Product name
- Z-L-cis-4-hydroxyproline 99+%
- Packaging
- 250mg
- Price
- $245
- Updated
- 2021/12/16
- Product number
- B194150
- Product name
- (2S,4S)-1-[(Benzyloxy)carbonyl]-4-hydroxypyrrolidine-2-carboxylicacid
- Packaging
- 500mg
- Price
- $340
- Updated
- 2021/12/16
- Product number
- 279910
- Product name
- Z-L-cis-4-hydroxyproline
- Packaging
- 500mg
- Price
- $382
- Updated
- 2021/12/16
- Product number
- 4H58-1-QA
- Product name
- (2S,4S)-1-[(Benzyloxy)carbonyl]-4-hydroxypyrrolidine-2-carboxylic acid
- Purity
- 97.0%
- Packaging
- 250mg
- Price
- $190
- Updated
- 2021/12/16
- Product number
- 057249
- Product name
- (2S,4S)-1-(Benzyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid
- Purity
- 98%
- Packaging
- 1g
- Price
- $240
- Updated
- 2021/12/16
Z-CIS-HYP-OH Chemical Properties,Usage,Production
Synthesis
117811-78-6
13504-86-4
General procedure for the synthesis of (2S,4S)-N-Cbz-4-hydroxypyrrolidine-2-carboxylic acid from (2S,4R)-Cbz-4-methanesulfonyloxyproline methyl ester: firstly, 708 g of water and 337 g of 48% sodium hydroxide solution were added to 928 g of the crude product obtained by reference to Example 3. The temperature of the mixture was raised to 80°C and the reaction was ripened at this temperature for 3 hours. Upon completion of the maturation, the temperature was kept constant and 146 g of solvent was distilled under reduced pressure until the pressure was reduced to 13 kPa. Subsequently, the mixture was cooled to 20°C, 180 g of 48% sodium hydroxide solution was added and aged at 25°C for 12 hours. The amount of cis-Benzyloxycarbonyl-4-hydroxy-L-proline in the reaction solution was determined by analysis to be 2.19 mol (81.0% yield based on trans-4-hydroxy-L-proline). Next, 35 g of toluene was added to the hydrolysis reaction solution and the mixture was concentrated under reduced pressure at 7 kPa and 40 °C to distill 332 g of solvent. Then, 161 g of concentrated sulfuric acid was added dropwise to the concentrated solution and the pH was adjusted to 1.3. After acidic adjustment, 710 g of tetrahydrofuran and 354 g of water were added for layered separation. To the separated water layer, 356 g of tetrahydrofuran was added and the separation was performed again. All the separated tetrahydrofuran layers were combined and concentrated at 40 °C under reduced pressure at 26 kPa, resulting in 896 g of concentrate containing 2.12 mol of cis-Benzyloxycarbonyl-4-hydroxy-L-proline (90.2% yield) with a cis/trans ratio of 98.3/1.7.
References
[1] Patent: JP5703654, 2015, B2. Location in patent: Paragraph 0054; 0055
Z-CIS-HYP-OH Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Z-CIS-HYP-OH manufacturers
- Product
- Z-CIS-HYP-OH 13504-86-4
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2020-02-13