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1,5-ISOQUINOLINEDIOL

Product Name
1,5-ISOQUINOLINEDIOL
CAS No.
5154-02-9
Chemical Name
1,5-ISOQUINOLINEDIOL
Synonyms
DHQ;DIQ;NSC 65585;1,5-ISOQUINOLINEDIOL;isoquinoline-1,5-diol;5-HYDROXYISOCARBOSTYRIL;1,5-Isoquinolinediol,98%;5-Hydroxy-isoquinolinone;1,5-DIHYDROXYISOQUINOLINE;1,5-Isoquinolinediol ,97%
CBNumber
CB5360303
Molecular Formula
C9H7NO2
Formula Weight
161.16
MOL File
5154-02-9.mol
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1,5-ISOQUINOLINEDIOL Property

Melting point:
270-275 °C
Boiling point:
287.44°C (rough estimate)
Density 
1.2480 (rough estimate)
refractive index 
1.5050 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMSO: >36 mg/mL
form 
solid
pka
8.52±0.20(Predicted)
color 
off-white
CAS DataBase Reference
5154-02-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-37/39
WGK Germany 
3
HS Code 
29337900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P233Keep container tightly closed.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304IF INHALED:

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P340Remove victim to fresh air and keep at rest in a position comfortable for breathing.

P362Take off contaminated clothing and wash before reuse.

P403Store in a well-ventilated place.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
419800
Product name
PARP Inhibitor IV, IQD - CAS 1188540 - Calbiochem
Purity
The PARP Inhibitor IV, IQD, also referenced under CAS 1188540, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.
Packaging
5MG
Price
$96.4
Updated
2023/01/07
Sigma-Aldrich
Product number
I138
Product name
1,5-Isoquinolinediol
Purity
≥98% (HPLC), powder
Packaging
5MG
Price
$59.9
Updated
2022/05/15
Cayman Chemical
Product number
14438
Product name
1,5-Isoquinolinediol
Purity
≥98%
Packaging
5mg
Price
$36
Updated
2024/03/01
Cayman Chemical
Product number
14438
Product name
1,5-Isoquinolinediol
Purity
≥98%
Packaging
25mg
Price
$78
Updated
2024/03/01
Cayman Chemical
Product number
14438
Product name
1,5-Isoquinolinediol
Purity
≥98%
Packaging
100mg
Price
$207
Updated
2024/03/01
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1,5-ISOQUINOLINEDIOL Chemical Properties,Usage,Production

Description

The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis. 1,5-Isoquinolinediol is an inhibitor of poly(ADP-ribose) synthetase (PARP1; IC50 = 0.39 μM). It has been used to study the role of PARP1 in both DNA repair and oxidant stress-induced cell death. This compound can be used with cells in culture and in animals.

Chemical Properties

white to off-white solid

Uses

Reagent used in the preparation of PARP inhibitor.

Uses

1,5-Isoquinolinediol can be used as a reagent in the preparation of PARP inhibitor.

Definition

ChEBI: An isoquinolinol that is isoquinoline in which the hydrogens at positions 1 and 5 are replaced by hydroxy groups.

General Description

A potent inhibitor of poly(ADP-ribose) polymerase (PARP; IC50 = 390 nM). Reported to partially block SNAP (CN 487910)- induced cell death in SH-SYSY human neuroblastoma cells.

Biochem/physiol Actions

Cell permeable: yes

storage

+4°C

1,5-ISOQUINOLINEDIOL Preparation Products And Raw materials

Raw materials

Preparation Products

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1,5-ISOQUINOLINEDIOL Suppliers

Belgium 1 Canada 2 China 68 Czech 1 France 1 India 1 Italy 1 Japan 1 South Korea 1 Switzerland 3 United Kingdom 4 United States 23 USA 1 Global 108
Leancare Ltd.
Tel
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Fax
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Email
enquiry@leancare.co.uk
Country
United Kingdom
ProdList
6446
Advantage
42
MOLEKULA Ltd.
Tel
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Fax
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Email
kevinbanks@molekula.com
Country
United Kingdom
ProdList
6140
Advantage
66
CARBONE SCIENTIFIC CO.,LTD
Tel
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Fax
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Email
sales@carbonesci.com
Country
United Kingdom
ProdList
6666
Advantage
30
VWR International
Tel
--
Fax
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Email
solutions@vwr.com
Country
United Kingdom
ProdList
6548
Advantage
82
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View Lastest Price from 1,5-ISOQUINOLINEDIOL manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
1,5-Isoquinolinediol 5154-02-9
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-04-07

5154-02-9, 1,5-ISOQUINOLINEDIOLRelated Search:

1,5-ISOQUINOLINEDIOL 7-isoquinolinediol,1-((3,4-dihydroxyphenyl)methyl)-1,2,3,4-tetrahydro-h 1,2,3,4-TETRAHYDRO-1-METHYL-6,7-ISOQUINOLINEDIOL HYDROBROMIDE,1,2,3,4-Tetrahydro-1-methyl-6,7-Isoquinolinediol 1-[(3,4-Dihydroxyphenyl)methyl]-1,2,3,4-tetrahydro-2-methyl-6,7-isoquinolinediol 5-Hydroxyisoquinoline Isoquinoline Isocarbostyril 1,2,3,4-TETRAHYDRO-6,7-ISOQUINOLINEDIOL HYDROBROMIDE,1,2,3,4-TETRAHYDRO-6,7-ISOQUINOLINEDIOL HYDROBROMIDE 98% 1-(3,4-Dihydroxybenzyl)-6,7-isoquinolinediol Tretoquinol (S)-1,2,3,4-tetrahydro-6,7-dihydroxy-1-(3,4,5-trimethoxybenzyl)isoquinolinium chloride 5-METHOXY-2H-ISOQUINOLIN-1-ONE 6,7-Isoquinolinediol, 1-propyl- (9CI) d-1-(3,4,5-Trimethoxybenzyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline 6,7-Isoquinolinediol, 1-(1-methylethyl)- (9CI) 6,7-Isoquinolinediol, 1-[(1S)-1,2-dihydroxyethyl]-1,2,3,4-tetrahydro- (9CI) 3,4-Dihydro-6,7-isoquinolinediol. Tretoquinol hydrochloride

  • 1,5-ISOQUINOLINEDIOL
  • 1,5-DIHYDROXYISOQUINOLINE
  • 5-HYDROXYISOCARBOSTYRIL
  • 5-HYDROXY-1(2H)-ISOQUINOLINE
  • 5-HYDROXY-1(2H)-ISOQUINOLINONE
  • 1,5-ISOQUINOLINEDIOL(1,5-DIHYDROXYISOQUI NO-LINE)
  • 1,5-Dihydroxyisoquinoline, 5-Hydroxy-1(2H)-isoquinolinone, DiQ
  • 5-Hydroxyisoquinoline-1(2H)-one
  • DHQ
  • 1,5-Isoquinolinediol,98%
  • 1,5-dihydroxy-1(2H)-isoquinoline
  • 1,5-Isoquinolinediol ,97%
  • isoquinoline-1,5-diol
  • 5-hydroxyisoquinolin-1(2H)-one
  • 5-Hydroxy-isoquinolinone
  • NSC 65585
  • DIQ
  • 1(2H)-Isoquinolinone, 5-hydroxy-
  • 5-hydroxy-1,2-dihydroisoquinolin-1-one
  • Isoquinolinediol, 1,5- - NSC 65585
  • PARP,diabetic,1188540,oxidative,retinopathy,1,5 Isoquinolinediol,stress,inhibit,NADPH,1,5-Isoquinolinediol,Inhibitor,1,5Isoquinolinediol,oxidase,poly ADP ribose polymerase
  • 5154-02-9
  • PARP Regulators
  • PARP
  • BioChemical
  • Apoptosis and Cell Cycle
  • Cell Signaling and Neuroscience
  • Cell Biology
  • Aromatics
  • Inhibitors