1-METHYLCYTOSIN

Product Name: 1-METHYLCYTOSIN
CAS No.: 1122-47-0
Chemical Name: 1-METHYLCYTOSIN
Synonyms: NSC 47693;1-METHYLCYTOSIN;1-METHYLCYTOSINE;N1-Methylcytosine;RARECHEM AQ NN 0292;4-amino-1-methylpyrimidin-2-one;1-Methylcytosine, 10 mM in DMSO;4-amino-1-methyl-pyrimidin-2-one;4-azanyl-1-methyl-pyrimidin-2-one;4-Amino-1-methyl-2(1H)-pyrimidinone
CBNumber: CB5360974
Molecular Formula: C5H7N3O
Formula Weight: 125.13
MOL File: 1122-47-0.mol

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1-METHYLCYTOSIN Property

Melting point:: 300-303℃
Boiling point:: 242℃
Density: 1.34
Flash point:: 100℃
storage temp.: Keep in dark place,Sealed in dry,2-8°C
solubility: Methanol (Slightly), Water (Slightly)
form: Solid
pka: 4.53±0.10(Predicted)
color: White to Off-White

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: A898218
Product name: 4-Amino-1-methylpyrimidin-2(1H)-one
Packaging: 50mg
Price: $120
Updated: 2021/12/16

ChemScene

Product number: CS-W006395
Product name: 1-Methylcytosine
Packaging: 1g
Price: $442
Updated: 2021/12/16

Matrix Scientific

Product number: 118359
Product name: 4-Amino-1-methylpyrimidin-2(1H)-one
Packaging: 1g
Price: $649
Updated: 2021/12/16

AK Scientific

Product number: 2618AL
Product name: 4-Amino-1-methylpyrimidin-2(1H)-one
Packaging: 1g
Price: $879
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0006848
Product name: 1-METHYLCYTOSIN
Purity: 95.00%
Packaging: 5G
Price: $1152.11
Updated: 2021/12/16

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1-METHYLCYTOSIN Chemical Properties,Usage,Production

Uses

1-Methylcytosine is a methylated form of the DNA base cytosine and used as a nucleobase of hachimoji DNA, in which it pairs with Isoguanine[1][2].

Definition

ChEBI: A pyrimidone that is cytosine in which the hydrogen attached to the nitrogen at position 1 is substituted by a methyl group.

Synthesis

77738-01-3

1122-47-0

4-N-(N,N-dimethylaminomethylene)-1-methylcytosine (1.0 g, 5.5 mmol) was added to a 100 mL round bottom flask equipped with a magnetic stirrer along with an ethanol solution (50 mL) containing 30% methylamine. The reaction mixture was stirred at room temperature for 12 hours. Upon completion of the reaction, the precipitated white solid was collected by filtration and purified by recrystallization using ethanol-water solvent mixture. 4-Amino-1-methylpyrimidin-2(1H)-one was finally obtained as a white solid (0.61 g, 88% yield). The structure of the product was analyzed by 1H NMR (400 MHz, DMSO-d6): δ3.31 (s, 3H), 5.59 (d, 1H), 6.91 (br, 2H), 7.54 (d, 1H); 13C NMR (100 MHz, DMSO-d6): δ6.6, 92.9, 146.6, 156.3, 166.1; mass spectrometry (ES+) ) analysis: calculated value C5H7N3O+ (M+H+) 126.0662, measured value 126.0804 confirmed.

References

[1] Kistenmacher, T. J.; Rossi, M. (1977-12-15). "1-Methylcytosine: a refinement". Acta Crystallographica (1977) Section B. 33 (12): 3962–3965.
[2] Hoshika S, et al. Hachimoji DNA and RNA: A genetic system with eight building blocks. Science. 2019 Feb 22;363(6429):884-887. DOI:10.1126/science.aat0971

1-METHYLCYTOSIN Preparation Products And Raw materials

Raw materials

Preparation Products

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1-METHYLCYTOSIN Suppliers

China 53 Germany 3 India 1 Russia 1 United Kingdom 3 United States 10 Global 71

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Shenzhen Regent Biochemical Technology Co., Ltd.

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View Lastest Price from 1-METHYLCYTOSIN manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 4-Amino-1-methylpyrimidin-2(1H)-one 1122-47-0
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 500 MT
Release date: 2020-05-25

1122-47-0, 1-METHYLCYTOSINRelated Search:

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1-METHYLCYTOSIN

1-METHYLCYTOSINE

NSC 47693

RARECHEM AQ NN 0292

1-Methyl-1,2,3,4-tetrahydro-4-iminopyrimidine-2-one

1-Methyl-4-amino-1,2-dihydropyrimidine-2-one

1-Methyl-4-aminopyrimidine-2(1H)-one

1-Methyl-4-imino-1,2,3,4-tetrahydropyrimidine-2-one

4-Amino-1-methyl-2(1H)-pyrimidinone

N1-Methylcytosine

4-amino-1-methyl-pyrimidin-2-one

4-amino-1-methylpyrimidin-2-one

4-azanyl-1-methyl-pyrimidin-2-one

4-aMino-1-MethylpyriMidin-2(1H)-one

4-AMino-1-Methyl-1H-pyriMidin-2-one

3-Oxazolidinecarboxylicacid,2,2-dimethyl-4-(2-oxoethyl)-,1,1-dimethylethylester,(5S)-

1-Methylcytosine, 10 mM in DMSO

1122-47-0