Cytidine 5’-monophosphate

Product Name: Cytidine 5’-monophosphate
CAS No.: 63-37-6
Chemical Name: Cytidine 5’-monophosphate
Synonyms: CMP;CYTIDYLIC ACID;CYTIDINE 5'-MONOPHOSPHATE;5'-CYTIDINE MONOPHOSPHATE;((2R,3S,4R,5R)-5-(4-aMino-2-oxopyriMidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)Methyl dihydrogen phosphate;C-5-P;C-5'-P;5'-CMP;CMP.H2;3'-CMP
CBNumber: CB2700845
Molecular Formula: C9H14N3O8P
Formula Weight: 323.2
MOL File: 63-37-6.mol

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Cytidine 5’-monophosphate Property

Melting point:: ~222 °C (dec.)
Boiling point:: 678.1±65.0 °C(Predicted)
Density: 2.15±0.1 g/cm3(Predicted)
refractive index: 9.8 ° (C=1, 0.5mol/L Na2HPO4)
storage temp.: 2-8°C
solubility: Water (Slightly, Heated)
pka: pK2:4.39(0);pK3:6.62(+1) (25°C)
form: crystalline
color: White
Water Solubility: soluble
BRN: 46982
InChI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
InChIKey: IERHLVCPSMICTF-JDNPWWSISA-N
SMILES: P(OC[C@H]1O[C@@H](N2C=CC(N)=NC2=O)[C@H](O)[C@@H]1O)(O)(O)=O
CAS DataBase Reference: 63-37-6(CAS DataBase Reference)
EPA Substance Registry System: 5'-Cytidylic acid (63-37-6)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 20/21/22-36/37/38
Safety Statements: 24/25-37/39-36-26
WGK Germany: 3
RTECS: HA3980000
F: 10-21
HS Code: 29349990
Toxicity: LD50 intraperitoneal in mouse: > 1gm/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C1131
Product name: Cytidine 5′-monophosphate
Purity: Sigma Grade, ≥99% (HPLC), synthetic, powder
Packaging: 1g
Price: $112
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1162126
Product name: 5′-Cytidylic acid
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 500mg
Price: $420
Updated: 2024/03/01

TCI Chemical

Product number: C1675
Product name: Cytidine 5'-Monophosphate
Purity: >98.0%(HPLC)
Packaging: 1g
Price: $49
Updated: 2024/03/01

TCI Chemical

Product number: C1675
Product name: Cytidine 5'-Monophosphate
Purity: >98.0%(HPLC)
Packaging: 5g
Price: $164
Updated: 2024/03/01

Sigma-Aldrich

Product number: C1131
Product name: Cytidine 5′-monophosphate
Purity: Sigma Grade, ≥99% (HPLC), synthetic, powder
Packaging: 500mg
Price: $74.8
Updated: 2024/03/01

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Cytidine 5’-monophosphate Chemical Properties,Usage,Production

Description

Cytidine 5'-monophosphate, also known as 5'-CMP, is a nucleotide that is used as a monomer in RNA. 5'-CMP is a key intermediate in the preparation of several nucleotide derivatives and is widely used in food and pharmaceutical industries.

Chemical Properties

white crystalline powder

Uses

A constituent of nucleic acids. It was isolated from yeast nucleic acid.

Uses

Cytidine 5′-monophosphate has been used in Raman spectroscopy studies.

Definition

ChEBI: A pyrimidine ribonucleoside 5'-monophosphate having cytosine as the nucleobase.

Production Methods

As a key intermediate in preparing several nucleotide derivatives, cytidine 5′-monophosphate (5′-CMP) is widely applied in food and pharmaceutical industries. Enzymatic synthesis of 5′-CMP is catalyzed by cytidine kinase (CK, EC 2.7.1.213), a type of nucleoside kinase that belongs to the PfkB family. Li et al. constructed a highly efficient biosynthesis system for manufacturing 5′-CMP in vitro. CK was used for the biotransformation of cytidine to 5′-CMP, while polyphosphate kinase (PPK) was coupled for adenosine triphosphate regeneration. Both CK and PPK were selected from extremophiles, possessing great potential for biocatalytic synthesis. After optimization, 96 mM 5′-CMP was produced within 6 h, and the yield reached nearly 100%[1].

Biochem/physiol Actions

Cytidine 5′-monophosphate (CMP) is used as a substrate of uridine monophosphate (UMP)/cytidine monophosphate (CMP) kinase (EC 2.7.4.4) to form CDP which upon phosphorylation to CTP supports DNA and RNA biosynthesis.

References

[1] Zonglin Li. “Efficient One-Pot Synthesis of Cytidine 5′-Monophosphate Using an Extremophilic Enzyme Cascade System.” Journal of Agricultural and Food Chemistry 68 34 (2020): 9188–9194.

Cytidine 5’-monophosphate Preparation Products And Raw materials

Raw materials

Preparation Products

Polyinosinic acid-polycytidylic acid

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Cytidine 5’-monophosphate Suppliers

Americas 1 Belgium 2 Canada 1 China 562 Czech Republic 1 Europe 3 France 1 Germany 7 India 22 Italy 1 Japan 2 Poland 1 Slovakia 1 Switzerland 3 United Kingdom 11 United States 39 Global 658

Anhui Chnbio Technology Co., Ltd.

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Meryer (Shanghai) Chemical Technology Co., Ltd.

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View Lastest Price from Cytidine 5’-monophosphate manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

Product: Cytidine 5’-monophosphate 63-37-6
Price: US $999.00-666.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000
Release date: 2024-08-20

Xinxiang Aurora Biotechnology Co.,Ltd.

Product: Cytidine 5'-monophosphate 63-37-6
Price: US $0.00/Kg
Min. Order: 1Kg
Purity: 98%
Supply Ability: 20 tons
Release date: 2024-10-22

HebeiShuoshengImportandExportco.,Ltd

Product: Cytidylic acid 63-37-6
Price: US $6.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000KG/Month
Release date: 2024-08-07

63-37-6, Cytidine 5’-monophosphateRelated Search:

Polyinosinic acid-polycytidylic acid Tributyl phosphate L-DIHYDROOROTIC ACID NUCLEOSIDE PHOSPHORYLASE BACTERIAL Cytosine Ethyl 2-(Chlorosulfonyl)acetate Tylosin phosphate Triethyl phosphate Fluorocytosine Ribavirin AMPHISOL A Hyaluronic acid Citric acid 5-Fluorocytidine 5-Azacytidine Trisodium phosphate Folic acid Cytidine-5'-triphosphate disodium salt dihydrate

C-5'-P

C-5-P

CMP MONOHYDRATE

CMP

CYTIDYLIC ACID

CYTIDINE 5'-MONOPHOSPHATE

CYTIDINE-5'-MONOPHOSPHATE MONOHYDRATE

CYTIDINE-5'-MONOPHOSPHORIC ACID

5'-CYTIDINE MONOPHOSPHATE

5'-CYTIDYLIC ACID

5'-CYTIDYLIC ACID MONOHYDRATE

5'-CMP

Cytidine Monophosphate and salts

Cytidine 5'-monophate

CYTIDINE 5'-MONOPHOSPHATE FREE ACIDSIGMA GRADE FRO

Cmp:Cytidine-5'-MonophosphateFreeAcid

CYTIDINE 5'-MONOPHOSPHATE, FREE ACID (5'-CMP)

[5-(4-amino-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxyphosphonic acid

5''-CYTIDINE MONOPHOSPHORIC ACID(FREE ACID)

Cytidylic acid、CMP

Cytidine-5''-monophosphoric acid (and/or unspecified salts)

5'-cytidylate monophosphate

Cytidine 3'-(dihydrogen phosphate)

5-CYTIDYLICACID(5-CMP)

Cytidine 5’-Monophosphate(CMP)

CYTIDINE-5-MONOPHOSPHORIC ACID extrapure

5μ-CMP, 5μ-Cytidylic acid, C-5μ-P

Cytidine mono(dihydrogen phosphate)

Cytodine monophosphate: (Cytidine 5-monophosphate free acid)

Cytidine-5'-monophosphoric acid hydrate,99%

((2R,3S,4R,5R)-5-(4-Amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl di

5'-CMP 5'-Cytidylic acid C-5'-P CMP

4-Amino-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-5-yldihydrogenphosphate

Cytidine -5'- Monophosphate（CMP-H）

5'-CMP(Cytidine 5'-monophosphate free acid)

Cytidine-5'monophosphate(CMP),FREE ACID

CMP.H2

cytidylic acid ,5'-cMp

cytidine-5Monophophate

cmp(nucleotide)

cytidine5’-(dihydrogenphosphate)

cytidine5’-phosphate

cytidine5’-phosphoricacid

cytidinemonophosphate

((2R,3S,4R,5R)-5-(4-aMino-2-oxopyriMidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)Methyl dihydrogen phosphate

CYTIDINE-5'-MONOPHOSPHATE(P)

((2R,3S,4R,5R)-5-(4-Amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihyd

5'-CMPH2

5'-Cytidylic Acid (500 mg)

5 ' - Cyticline Monophosphoric Acid (Free Acid )

4-aMino-1-(O5-phosphono-pentofuranosyl)-1H-pyriMidin-2-one

Cytidylic acid SynonyMs 5'-cytidylate Monophosphate

Cytidine 5'-monophosphate (5'-CMP)

Cytidine 5′-monophosphate, synthetic, 99%

Cytidine 5'-Monophosphate &gt

Cytidylic acid Solution, 100μg/mL

-cytidylate monophosphate

5'-CYTIDYLATE MONOPHOSPHATE（CMP）