Cytidine 5’-monophosphate
- Product Name
- Cytidine 5’-monophosphate
- CAS No.
- 63-37-6
- Chemical Name
- Cytidine 5’-monophosphate
- Synonyms
- CMP;CYTIDYLIC ACID;CYTIDINE 5'-MONOPHOSPHATE;5'-CYTIDINE MONOPHOSPHATE;((2R,3S,4R,5R)-5-(4-aMino-2-oxopyriMidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)Methyl dihydrogen phosphate;C-5-P;C-5'-P;5'-CMP;CMP.H2;3'-CMP
- CBNumber
- CB2700845
- Molecular Formula
- C9H14N3O8P
- Formula Weight
- 323.2
- MOL File
- 63-37-6.mol
Cytidine 5’-monophosphate Property
- Melting point:
- ~222 °C (dec.)
- Boiling point:
- 678.1±65.0 °C(Predicted)
- Density
- 2.15±0.1 g/cm3(Predicted)
- refractive index
- 9.8 ° (C=1, 0.5mol/L Na2HPO4)
- storage temp.
- 2-8°C
- solubility
- Water (Slightly, Heated)
- pka
- pK2:4.39(0);pK3:6.62(+1) (25°C)
- form
- crystalline
- color
- White
- Water Solubility
- soluble
- BRN
- 46982
- InChI
- InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
- InChIKey
- IERHLVCPSMICTF-JDNPWWSISA-N
- SMILES
- P(OC[C@H]1O[C@@H](N2C=CC(N)=NC2=O)[C@H](O)[C@@H]1O)(O)(O)=O
- CAS DataBase Reference
- 63-37-6(CAS DataBase Reference)
- EPA Substance Registry System
- 5'-Cytidylic acid (63-37-6)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 24/25-37/39-36-26
- WGK Germany
- 3
- RTECS
- HA3980000
- F
- 10-21
- HS Code
- 29349990
- Toxicity
- LD50 intraperitoneal in mouse: > 1gm/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C1131
- Product name
- Cytidine 5′-monophosphate
- Purity
- Sigma Grade, ≥99% (HPLC), synthetic, powder
- Packaging
- 1g
- Price
- $112
- Updated
- 2024/03/01
- Product number
- 1162126
- Product name
- 5′-Cytidylic acid
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 500mg
- Price
- $420
- Updated
- 2024/03/01
- Product number
- C1675
- Product name
- Cytidine 5'-Monophosphate
- Purity
- >98.0%(HPLC)
- Packaging
- 1g
- Price
- $49
- Updated
- 2024/03/01
- Product number
- C1675
- Product name
- Cytidine 5'-Monophosphate
- Purity
- >98.0%(HPLC)
- Packaging
- 5g
- Price
- $164
- Updated
- 2024/03/01
- Product number
- C1131
- Product name
- Cytidine 5′-monophosphate
- Purity
- Sigma Grade, ≥99% (HPLC), synthetic, powder
- Packaging
- 500mg
- Price
- $74.8
- Updated
- 2024/03/01
Cytidine 5’-monophosphate Chemical Properties,Usage,Production
Description
Cytidine 5'-monophosphate, also known as 5'-CMP, is a nucleotide that is used as a monomer in RNA. 5'-CMP is a key intermediate in the preparation of several nucleotide derivatives and is widely used in food and pharmaceutical industries.
Chemical Properties
white crystalline powder
Uses
A constituent of nucleic acids. It was isolated from yeast nucleic acid.
Uses
Cytidine 5′-monophosphate has been used in Raman spectroscopy studies.
Definition
ChEBI: A pyrimidine ribonucleoside 5'-monophosphate having cytosine as the nucleobase.
Production Methods
As a key intermediate in preparing several nucleotide derivatives, cytidine 5′-monophosphate (5′-CMP) is widely applied in food and pharmaceutical industries. Enzymatic synthesis of 5′-CMP is catalyzed by cytidine kinase (CK, EC 2.7.1.213), a type of nucleoside kinase that belongs to the PfkB family. Li et al. constructed a highly efficient biosynthesis system for manufacturing 5′-CMP in vitro. CK was used for the biotransformation of cytidine to 5′-CMP, while polyphosphate kinase (PPK) was coupled for adenosine triphosphate regeneration. Both CK and PPK were selected from extremophiles, possessing great potential for biocatalytic synthesis. After optimization, 96 mM 5′-CMP was produced within 6 h, and the yield reached nearly 100%[1].
Biochem/physiol Actions
Cytidine 5′-monophosphate (CMP) is used as a substrate of uridine monophosphate (UMP)/cytidine monophosphate (CMP) kinase (EC 2.7.4.4) to form CDP which upon phosphorylation to CTP supports DNA and RNA biosynthesis.
References
[1] Zonglin Li. “Efficient One-Pot Synthesis of Cytidine 5′-Monophosphate Using an Extremophilic Enzyme Cascade System.” Journal of Agricultural and Food Chemistry 68 34 (2020): 9188–9194.
Cytidine 5’-monophosphate Preparation Products And Raw materials
Raw materials
Preparation Products
Cytidine 5’-monophosphate Suppliers
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
- sales@tciamerica.com
- Country
- Americas
- ProdList
- 23653
- Advantage
- 75
View Lastest Price from Cytidine 5’-monophosphate manufacturers
- Product
- Cytidylic acid 63-37-6
- Price
- US $0.00-0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 98%min HPLC
- Supply Ability
- 1000KG
- Release date
- 2021-06-18
- Product
- Cytidine 5'-monophosphate 63-37-6
- Price
- US $0.00/Kg
- Min. Order
- 1Kg
- Purity
- 98%
- Supply Ability
- 20 tons
- Release date
- 2024-10-22
- Product
- Cytidine 5’-monophosphate 63-37-6
- Price
- US $999.00-666.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000
- Release date
- 2024-08-20