ChemicalBook > CAS DataBase List > METHYL 2,5-DICHLORONICOTINATE

METHYL 2,5-DICHLORONICOTINATE

Product Name: METHYL 2,5-DICHLORONICOTINATE
CAS No.: 67754-03-4
Chemical Name: METHYL 2,5-DICHLORONICOTINATE
Synonyms: 5-dichloronicotinate;METHYL 2,5-DICHLORONICOTINATE;Methyl2,5-Dichloronicotinate>5-dichloropyridine-3-carboxylate;2,5-Dichloro-nicotinic acid Methyl ester;Methyl 2,5-dichloropyridine-3-carboxylate;2,5-Dichloropyridine-3-carboxylic Acid Methyl Ester;2,5-dichloro-3-pyridinecarboxylic acid methyl ester;3-Pyridinecarboxylic acid, 2,5-dichloro-, Methyl ester;Methyl 2,5-dichloropyridine-3-carboxylate, 2,5-Dichloro-3-(methoxycarbonyl)pyridine
CBNumber: CB5360989
Molecular Formula: C7H5Cl2NO2
Formula Weight: 206.03
MOL File: 67754-03-4.mol

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METHYL 2,5-DICHLORONICOTINATE Property

Melting point:: 38-40°C
Boiling point:: 267℃
Density: 1.426
Flash point:: 115℃
storage temp.: Inert atmosphere,Room Temperature
form: powder to crystal
pka: -3.78±0.10(Predicted)
color: White to Almost white
InChI: InChI=1S/C7H5Cl2NO2/c1-12-7(11)5-2-4(8)3-10-6(5)9/h2-3H,1H3
InChIKey: CNPFXYWTMBTSSI-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=C(Cl)C=C1C(OC)=O

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Safety

HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical

Product number: M2752
Product name: Methyl 2,5-Dichloronicotinate
Purity: >98.0%(GC)
Packaging: 200mg
Price: $32
Updated: 2025/07/31

TCI Chemical

Product number: M2752
Product name: Methyl 2,5-Dichloronicotinate
Purity: >98.0%(GC)
Packaging: 1g
Price: $96
Updated: 2025/07/31

TRC

Product number: M326353
Product name: Methyl 2,5-Dichloronicotinate
Packaging: 500mg
Price: $130
Updated: 2021/12/16

Chem-Impex

Product number: 44769
Product name: Methyl2,5-Dichloronicotinate,≥98%(GC)
Purity: ≥98%(GC)
Packaging: 1G
Price: $132.14
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0026299
Product name: METHYL 2,5-DICHLORONICOTINATE
Purity: 95.00%
Packaging: 1G
Price: $771.89
Updated: 2021/12/16

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METHYL 2,5-DICHLORONICOTINATE Chemical Properties,Usage,Production

Synthesis

67-56-1

59782-85-3

67754-03-4

General procedure for the synthesis of methyl 2,5-dichloronicotinate from methanol and 2,5-dichloronicotinic acid: 2,5-dichloronicotinic acid (20.2 g, 0.105 mol) was dissolved in methanol (500 mL) at 0 °C and pure thionyl chloride (38 mL, 63 g, 0.525 mol) was added slowly. The reaction mixture was stirred at 0 °C for 1 h. After removing the cooling bath, the reaction temperature was allowed to rise naturally to room temperature and stirring was continued for 2 days. After completion of the reaction, the solvent was removed under reduced pressure to give an off-white residue. The residue was dissolved in ether (about 500 mL) and washed sequentially with saturated aqueous NaHCO3 solution (about 300 mL), water (about 300 mL) and brine (about 300 mL). The organic layer was separated, dried with anhydrous MgSO4 and filtered. The solvent was removed under reduced pressure to give methyl 2,5-dichloronicotinate as a white solid (21.0 g, 97% yield). Methyl 2,5-dichloronicotinate (4.5 g, 22 mmol) was dissolved in an ammonia solution (250 mL, 0.5 M, 0.125 mol) in 1,4-dioxane, sealed in a pressure vessel, and heated at (85±5) °C for 9 days. After completion of the reaction, it was cooled to room temperature, the reaction mixtures were combined and concentrated under reduced pressure to give a white solid. The solid was dissolved in acetone-MeOH (1:1, about 500 mL), adsorbed on silica gel (25 g), and purified by fast column chromatography (hexane-CH2Cl2-Et2O, 25:10:1) to afford methyl 2-amino-5-chloronicotinate (6.08 g, 75% yield). A solution of LiOH-H2O (1.38 g, 33 mmol) in water (33 mL) was added at once to a suspension of methyl 2-amino-5-chloronicotinate (6.08 g, 27 mmol) in MeOH (110 mL) and stirred at 70 °C for 24 hours. The reaction mixture gradually became homogeneous. The solvent was removed under reduced pressure and the resulting white solid was dried under vacuum (<1 mmHg) to constant weight to give lithium 2-amino-5-chloronicotinate (5.51 g, 95% yield).

References

[1] Patent: WO2006/88840, 2006, A1. Location in patent: Page/Page column 126-127
[2] Patent: WO2006/91428, 2006, A2. Location in patent: Page/Page column 124
[3] Patent: WO2006/88837, 2006, A2. Location in patent: Page/Page column 119-120
[4] Patent: WO2007/109238, 2007, A1. Location in patent: Page/Page column 99-100
[5] Patent: WO2011/130342, 2011, A1. Location in patent: Page/Page column 90

METHYL 2,5-DICHLORONICOTINATE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from METHYL 2,5-DICHLORONICOTINATE manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: METHYL 2,5-DICHLORONICOTINATE 67754-03-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-06-24

Zibo Hangyu Biotechnology Development Co., Ltd

Product: METHYL 2,5-DICHLORONICOTINATE 67754-03-4
Price: US $75.00-500.00/g
Min. Order: 5g
Purity: 99%
Supply Ability: 50
Release date: 2024-07-11

Career Henan Chemical Co

Product: METHYL 2,5-DICHLORONICOTINATE 67754-03-4
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: Customized
Release date: 2018-12-14

67754-03-4, METHYL 2,5-DICHLORONICOTINATERelated Search:

methyl 2,4-dichloronicotinate METHYL 2,6-DICHLORONICOTINATE Methyl 4,6-dichloronicotinate METHYL 5,6-DICHLORONICOTINATE 2,5-DICHLORONICOTINIC ACID PHENYL ESTER ETHYL 2,5,6-TRICHLORO-4-[(4-METHYLPHENYL)THIO]NICOTINATE 2,4,5,6-TETRACHLORO-NICOTINIC ACID ETHYL ESTER 4-CHLOROPHENYL 2,5-DICHLORONICOTINATE 3,5-DICHLOROPHENYL 2,5-DICHLORONICOTINATE 3-PYRIDINECARBOXYLIC ACID, 2,5-DICHLORO-, ETHYL ESTER 4-METHYLPHENYL 2,5-DICHLORONICOTINATE METHYL 2,5-DICHLORONICOTINATE

METHYL 2,5-DICHLORONICOTINATE

Methyl 2,5-dichloropyridine-3-carboxylate

5-dichloropyridine-3-carboxylate

3-Pyridinecarboxylic acid, 2,5-dichloro-, Methyl ester

2,5-Dichloro-nicotinic acid Methyl ester

Methyl 2,5-dichloropyridine-3-carboxylate, 2,5-Dichloro-3-(methoxycarbonyl)pyridine

2,5-dichloro-3-pyridinecarboxylic acid methyl ester

Methyl2,5-Dichloronicotinate&gt

2,5-Dichloropyridine-3-carboxylic Acid Methyl Ester

5-dichloronicotinate

67754-03-4