METHYL 2,5-DICHLORONICOTINATE
- Product Name
- METHYL 2,5-DICHLORONICOTINATE
- CAS No.
- 67754-03-4
- Chemical Name
- METHYL 2,5-DICHLORONICOTINATE
- Synonyms
- 5-dichloronicotinate;METHYL 2,5-DICHLORONICOTINATE;Methyl2,5-Dichloronicotinate>5-dichloropyridine-3-carboxylate;2,5-Dichloro-nicotinic acid Methyl ester;Methyl 2,5-dichloropyridine-3-carboxylate;2,5-Dichloropyridine-3-carboxylic Acid Methyl Ester;2,5-dichloro-3-pyridinecarboxylic acid methyl ester;3-Pyridinecarboxylic acid, 2,5-dichloro-, Methyl ester;Methyl 2,5-dichloropyridine-3-carboxylate, 2,5-Dichloro-3-(methoxycarbonyl)pyridine
- CBNumber
- CB5360989
- Molecular Formula
- C7H5Cl2NO2
- Formula Weight
- 206.03
- MOL File
- 67754-03-4.mol
METHYL 2,5-DICHLORONICOTINATE Property
- Melting point:
- 38-40°C
- Boiling point:
- 267℃
- Density
- 1.426
- Flash point:
- 115℃
- storage temp.
- Inert atmosphere,Room Temperature
- form
- powder to crystal
- pka
- -3.78±0.10(Predicted)
- color
- White to Almost white
- InChI
- InChI=1S/C7H5Cl2NO2/c1-12-7(11)5-2-4(8)3-10-6(5)9/h2-3H,1H3
- InChIKey
- CNPFXYWTMBTSSI-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=C(Cl)C=C1C(OC)=O
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- M2752
- Product name
- Methyl 2,5-Dichloronicotinate
- Purity
- >98.0%(GC)
- Packaging
- 200mg
- Price
- $32
- Updated
- 2025/07/31
- Product number
- M2752
- Product name
- Methyl 2,5-Dichloronicotinate
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $96
- Updated
- 2025/07/31
- Product number
- M326353
- Product name
- Methyl 2,5-Dichloronicotinate
- Packaging
- 500mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- 44769
- Product name
- Methyl2,5-Dichloronicotinate,≥98%(GC)
- Purity
- ≥98%(GC)
- Packaging
- 1G
- Price
- $132.14
- Updated
- 2021/12/16
- Product number
- HCH0026299
- Product name
- METHYL 2,5-DICHLORONICOTINATE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $771.89
- Updated
- 2021/12/16
METHYL 2,5-DICHLORONICOTINATE Chemical Properties,Usage,Production
Synthesis
67-56-1
59782-85-3
67754-03-4
General procedure for the synthesis of methyl 2,5-dichloronicotinate from methanol and 2,5-dichloronicotinic acid: 2,5-dichloronicotinic acid (20.2 g, 0.105 mol) was dissolved in methanol (500 mL) at 0 °C and pure thionyl chloride (38 mL, 63 g, 0.525 mol) was added slowly. The reaction mixture was stirred at 0 °C for 1 h. After removing the cooling bath, the reaction temperature was allowed to rise naturally to room temperature and stirring was continued for 2 days. After completion of the reaction, the solvent was removed under reduced pressure to give an off-white residue. The residue was dissolved in ether (about 500 mL) and washed sequentially with saturated aqueous NaHCO3 solution (about 300 mL), water (about 300 mL) and brine (about 300 mL). The organic layer was separated, dried with anhydrous MgSO4 and filtered. The solvent was removed under reduced pressure to give methyl 2,5-dichloronicotinate as a white solid (21.0 g, 97% yield). Methyl 2,5-dichloronicotinate (4.5 g, 22 mmol) was dissolved in an ammonia solution (250 mL, 0.5 M, 0.125 mol) in 1,4-dioxane, sealed in a pressure vessel, and heated at (85±5) °C for 9 days. After completion of the reaction, it was cooled to room temperature, the reaction mixtures were combined and concentrated under reduced pressure to give a white solid. The solid was dissolved in acetone-MeOH (1:1, about 500 mL), adsorbed on silica gel (25 g), and purified by fast column chromatography (hexane-CH2Cl2-Et2O, 25:10:1) to afford methyl 2-amino-5-chloronicotinate (6.08 g, 75% yield). A solution of LiOH-H2O (1.38 g, 33 mmol) in water (33 mL) was added at once to a suspension of methyl 2-amino-5-chloronicotinate (6.08 g, 27 mmol) in MeOH (110 mL) and stirred at 70 °C for 24 hours. The reaction mixture gradually became homogeneous. The solvent was removed under reduced pressure and the resulting white solid was dried under vacuum (<1 mmHg) to constant weight to give lithium 2-amino-5-chloronicotinate (5.51 g, 95% yield).
References
[1] Patent: WO2006/88840, 2006, A1. Location in patent: Page/Page column 126-127
[2] Patent: WO2006/91428, 2006, A2. Location in patent: Page/Page column 124
[3] Patent: WO2006/88837, 2006, A2. Location in patent: Page/Page column 119-120
[4] Patent: WO2007/109238, 2007, A1. Location in patent: Page/Page column 99-100
[5] Patent: WO2011/130342, 2011, A1. Location in patent: Page/Page column 90
METHYL 2,5-DICHLORONICOTINATE Preparation Products And Raw materials
Raw materials
Preparation Products
METHYL 2,5-DICHLORONICOTINATE Suppliers
- Tel
- --
- Fax
- --
- info@abcr.de
- Country
- Germany
- ProdList
- 6831
- Advantage
- 75
View Lastest Price from METHYL 2,5-DICHLORONICOTINATE manufacturers
- Product
- METHYL 2,5-DICHLORONICOTINATE 67754-03-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-06-24
- Product
- METHYL 2,5-DICHLORONICOTINATE 67754-03-4
- Price
- US $75.00-500.00/g
- Min. Order
- 5g
- Purity
- 99%
- Supply Ability
- 50
- Release date
- 2024-07-11
- Product
- METHYL 2,5-DICHLORONICOTINATE 67754-03-4
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2018-12-14