5-Hydroxyadamantan-2-one

Product Name: 5-Hydroxyadamantan-2-one
CAS No.: 20098-14-0
Chemical Name: 5-Hydroxyadamantan-2-one
Synonyms: HADON;kemantane;AKOS BB-9629;CHEMBRDG-BB 4013898;Hydroxyadamantanone;Adamantan-4-on-1-ol;5-Hydroxy-2-adamantone;Kemantane( Idramantone);5-HYDROXY-2-ADAMANTANONE;5-Hydroxyadamantan-2-one
CBNumber: CB5361850
Molecular Formula: C10H14O2
Formula Weight: 166.22
MOL File: 20098-14-0.mol

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5-Hydroxyadamantan-2-one Property

Melting point:: >300 °C (lit.)
Boiling point:: 296.5±33.0 °C(Predicted)
Density: 1.301±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO, Methanol
pka: 14.69±0.20(Predicted)
form: Crystalline Powder
color: White to off-white
InChI: InChI=1S/C10H14O2/c11-9-7-1-6-2-8(9)5-10(12,3-6)4-7/h6-8,12H,1-5H2
InChIKey: TZBDEVBNMSLVKT-RIKBPLFRSA-N
SMILES: C12CC3(O)CC(CC(C3)C1=O)C2
CAS DataBase Reference: 20098-14-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 24/25-36/37/39-27-26
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29144000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 423807
Product name: 5-Hydroxy-2-adamantanone
Purity: 98%
Packaging: 1g
Price: $26.3
Updated: 2023/06/20

TCI Chemical

Product number: H0962
Product name: 5-Hydroxy-2-adamantanone
Purity: >98.0%(GC)
Packaging: 1g
Price: $34
Updated: 2025/07/31

TCI Chemical

Product number: H0962
Product name: 5-Hydroxy-2-adamantanone
Purity: >98.0%(GC)
Packaging: 5g
Price: $130
Updated: 2025/07/31

TCI Chemical

Product number: H0962
Product name: 5-Hydroxy-2-adamantanone
Purity: >98.0%(GC)
Packaging: 25g
Price: $386
Updated: 2025/07/31

Usbiological

Product number: 161910
Product name: 5-Hydroxy-2-adamantanone
Packaging: 2.5g
Price: $403
Updated: 2021/12/16

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5-Hydroxyadamantan-2-one Chemical Properties,Usage,Production

Description

5-Hydroxy-2-adamantanone (5-hydroxyadamantan-2-one) is a versatile starting material for synthesising various 2,5- or 1,4-disubstituted adamantanes. Chemical methods for synthesizing 5-hydroxy-2-adamantanone include disproportionation of 2-hydroxyadamantane and oxidation of 2-adamantanone. A synthetic approach to produce 5-hydroxy-2-adamantanone using P450cam (CYP101A1; a camphor monooxygenase) coupled with NADH regeneration as an oxidation biocatalyst has been reported[1].

Chemical Properties

White crystal or crystalline powder

Uses

anthelmintic

Uses

5-Hydroxy-2-adamantanone may be used in the following studies:

As a model compound to investigate the application of lanthanide NMR shift reagents for the analysis of disubstituted derivative of adamantane.
As a starting material for the synthesis of E-2-amino-5-hydroxyadamantane.
As a starting material for the synthesis of 4-(triphenylsilyloxy)adamantan-1-ol.

Definition

ChEBI: Idramantone is a member of adamantanones.

brand name

INDICLOR (Nycomed Amersham).

General Description

5-Hydroxy-2-adamantanone is a disubstituted derivative of adamantane. The biocatalyzed synthesis of 5-hydroxy-2-adamantanone from 2-adamantanone has been investigated.

Synthesis

700-58-3

20098-14-0

Step (i): Synthesis of 5-hydroxy-2-adamantanone (compound of formula 11) Under cooling in an ice bath, adamantanone (50 g, 333 mmol) was slowly added to concentrated nitric acid (98%, 440 mL) for 15 min while stirring was maintained. The reaction mixture was stirred continuously for 72 h at room temperature and then warmed to 60 °C for 2 h until most of the nitrogen dioxide gas escaped. Excess nitric acid was removed by distillation under reduced pressure and the resulting pale yellow oil solidified on cooling. The reaction mixture was sequentially diluted with deionized water (200 mL) and concentrated sulfuric acid (75 mL), and the resulting clarified yellow solution was heated on a steam bath in a fume hood for 1 hour. The reaction solution was neutralized with 30% aqueous sodium hydroxide under warm conditions and subsequently extracted with chloroform. The organic phases were combined, washed with saturated saline and concentrated under reduced pressure. The crude product was dissolved in dichloromethane (15 mL), hexane was added dropwise until the precipitate was no longer generated, the solid was collected by filtration and dried under vacuum to give 5-hydroxy-2-adamantanone (compound of formula 11, 40.9 g) in 74% yield. Characterization data: Melting point: 278.8-300°C; 1H-NMR (CDCl3) δ: 2.69 (bs, 2H), 2.36-2.32 (m, 2H), 2.12-2.02 (m, 2H), 2.02-1.88 (m, 6H), 1.80-1.68 (m, 1H); IR (cm-1): 3410, 2929, 2855, 2645, 1725, 1539, 1452, 1351, 1288, 1116, 1055, 927, 900, 797; Mass spectrum (m/z): 167 [M+H]+.

References

[1] Toshiki Furuya . “Biocatalytic production of 5-hydroxy-2-adamantanone by P450cam coupled with NADH regeneration.” Journal of Molecular Catalysis B-enzymatic 94 (2013): Pages 111-118.

5-Hydroxyadamantan-2-one Preparation Products And Raw materials

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5-Hydroxyadamantan-2-one Suppliers

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View Lastest Price from 5-Hydroxyadamantan-2-one manufacturers

Dideu Industries Group Limited

Product: 5-Hydroxyadamantan-2-one 20098-14-0
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2025-09-17

Wuhan JiyunZen Tech Co., Ltd.

Product: 5-Hydroxyadamantan-2-one 20098-14-0
Price: US $5.00-0.50/KG
Min. Order: 1KG
Purity: 99% hplc
Supply Ability: 500TONS
Release date: 2025-05-30

Shanghai Qyubiotech Co., Ltd.

Product: 5-Hydroxy-2-adamantanone 20098-14-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%+
Supply Ability: 1000kg per Month
Release date: 2023-08-11

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Adamantanes

Building Blocks

Carbonyl Compounds

C10

Organic Building Blocks

Ketones

Adamantane derivatives

C10

Carbonyl Compounds

Ketones

pharmacetical

Adamantanes